GEO DataSets

Analysis of multiple myeloma (MM) tumors and splenic B cells from transgenics overexpressing XBP-1s. XBP-1s is a spliced isoform of XBP-1, a factor that governs unfolded protein/ER stress response and plasma-cell development. Results provide insight into the role of XBP-1 in MM pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 specimen, 2 strain sets

Platform:

GPL1261

Series:

GSE6980

16 Samples

Download data: CEL

(Submitter supplied) Multiple myeloma (MM) evolves from highly prevalent premalignant condition termed Monoclonal Gammopathy of Undetermined Significance (MGUS). We report an MGUS-MM phenotype arising in transgenic mice with Emu-directed expression of the unfolded protein/ER stress response and plasma cell development spliced isoform factor XBP-1s. Emu-XBP-1s elicited elevated serum Ig and IL-6 levels, skin alterations and with advancing age, a significant proportion of Emu-xbp-1s transgenic mice develop features diagnostic of human MM including bone lytic lesions. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2640

Platform:

GPL1261

16 Samples

Download data: CEL

(Submitter supplied) IL-2 signals into CD8 T cells have a programming and regulatory role in driving cells to full effector and memory differentiation. This study was designed to look for IL-2 target genes that affect CD8 T cell responses. Keywords: Time-course, cytokine treatment Keywords: Expression profiling by array

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

3 Samples

Download data: CEL, CHP

(Submitter supplied) The zinc finger transcription factor growth-factor-independent-1 (Gfi1) has been involved in various cellular differentiation processes. Gfi1 acts as a transcriptional repressor and splicing control factor upon binding to cognate binding sites in regulatory elements of its target genes. Here, we report that Gfi1-deficient mice develop autoimmunity. Gfi1-deficient peripheral B-cells show a hyperproliferative phenotype, leading to expansion of plasma cells, increased levels of nuclear autoantibodies, and immunoglobulin deposition in brain and kidneys. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

2 Samples

Download data: CEL