GEO DataSets

Analysis of animals overexpressing the basic helix-loop-helix (bHLH) transcription factor Twist and its heterodimeric bHLH partner E/DA. Twist is important in mesoderm development. Results provide insight into the function of Twist in mesoderm development.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 2 protocol, 2 strain sets

Platform:

GPL200

Series:

GSE2862

12 Samples

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(Submitter supplied) Three biological replicates of each treatment were generated and the expression profiles were determined using Affymetrix C. elegans arrays. Comparisons between the sample groups allow the identification of genes expression patterns. Keywords: repeat

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Dataset:

GDS2463

Platform:

GPL200

12 Samples

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(Submitter supplied) By screening for genes possessing canonical X-box sequences in promoters of three Caenorhabditis species, namely C. elegans, C. briggsae and C. remanei, we identified 93 genes (including known X-box regulated genes) that encode putative components of ciliated neurons in C. elegans and are subject to the same regulatory control. For many of these genes, restricted anatomical expression in ciliated cells was confirmed, and control of transcription by the ciliogenic DAF-19 RFX transcription factor was demonstrated by comparative transcriptional profiling of daf-19(+) and daf-19(-) animals. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Dataset:

GDS2549

Platform:

GPL200

4 Samples

Download data: CEL

Analysis of mutants lacking DAF-19, a transcription factor that regulates genes involved in cilia function. Cilia defects are associated with a variety of human disorders, such as cystic kidney disease. Results provide insight into the mechanisms that regulate the formation and function of cilia.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL200

Series:

GSE6563

4 Samples

Download data: CEL

(Submitter supplied) The pha-4 locus encodes a forkhead box A (FoxA/HNF3) transcription factor homolog that specifies organ identity for Caenorhabditis elegans pharyngeal cells. We used microarrays to identify pharyngeal genes and analyzed those genes to determine which were direct PHA-4 targets. Our data suggest that PHA-4 directly activates most or all pharyngeal genes. Furthermore, the relative affinity of PHA-4 for different TRTTKRY (R = A/G, K = T/G, Y = T/C) elements modulates the onset of gene expression, providing a mechanism to activate pharyngeal genes at different developmental stages. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platforms:

GPL3177 GPL3178

3 Samples

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(Submitter supplied) A temporal gradient of the novel nuclear protein LIN-14 specifies the timing and sequence of stage-specific developmental events in Caenorhabditis elegans. The profound effects of lin-14 mutations on worm development suggest that LIN-14 directly or indirectly regulates stage-specific gene expression. We show that LIN-14 can associate with chromatin in vivo and has in vitro DNA binding activity. A bacterially expressed C-terminal domain of LIN-14 was used to select DNA sequences that contain a putative consensus binding site from a pool of randomized double-stranded oligonucleotides. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platforms:

GPL14 GPL2646

6 Samples

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(Submitter supplied) The hlh-30 gene encodes a C. elegans basic-helix-loop-helix (bHLH) transcription factor; We compared RNA from wild type worms and worms mutant for the hlh-30 gene to identify putative target genes of the HLH-30 transcription factor.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

6 Samples

Download data: CEL