GEO DataSets

Analysis of pancreata and submandibular and lacrimal glands from 6-, 9-, and 15-week-old NOD/scid animals, respectively, before the onset of autoimmune destruction of the tissues. The NOD/scid animal is a model for type 1 diabetes. The three organs examined are autoimmune targets in type 1 diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 2 strain, 3 tissue sets

Platform:

GPL83

Series:

GSE4953

39 Samples

Download data

(Submitter supplied) Prior to the onset of autoimmune destruction, type 1 diabetic patients and an animal model thereof, the nonobese diabetic (NOD) mouse, show morphological and functional abnormalities in target organs, which may act as inciting events for leukocyte infiltration. To better understand these abnormalities, but without the complications associated with inflammatory infiltrates, we examined genes expressed in autoimmune target tissues (pancreas, submandibular glands, and lacrimal glands) of NOD/scid mice and of autoimmune-resistant C57BL6/scid mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS2177 GDS2178 GDS2179

Platforms:

GPL81 GPL82 GPL83

117 Samples

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Analysis of pancreata and submandibular and lacrimal glands from 6-, 9-, and 15-week-old NOD/scid animals, respectively, before the onset of autoimmune destruction of the tissues. The NOD/scid animal is a model for type 1 diabetes. The three organs examined are autoimmune targets in type 1 diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 2 strain, 3 tissue sets

Platform:

GPL82

Series:

GSE4953

39 Samples

Download data

Analysis of pancreata and submandibular and lacrimal glands from 6-, 9-, and 15-week-old NOD/scid animals, respectively, before the onset of autoimmune destruction of the tissues. The NOD/scid animal is a model for type 1 diabetes. The three organs examined are autoimmune targets in type 1 diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 2 strain, 3 tissue sets

Platform:

GPL81

Series:

GSE4953

39 Samples

Download data

(Submitter supplied) To search for new therapeutic targets for type 1 & 2 diabetes, we have applied genome wide transcriptional profiling and systems biology oriented bioinformatics analysis to examine the impact of the Power mix(PM) and Alpha-1 Anti-Trypsin( AAT) regimens upon pancreatic lymph node (PLN) and fat, a crucial tissue for insulin dependent glucose disposal, in new onset diabetic NOD mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

19 Samples

Download data: CEL, CHP

(Submitter supplied) In this study, we performed the gene expression analysis of the Normal, Diabetic and AAT treated NOD mice to elucidate the transcriptional changes induced by AAT. This will assist in identifying the biological processes / pathways involved in curative mechanism of AAT. Keywords: alpha1 antitrypsin treatment

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

6 Samples

Download data: CEL

(Submitter supplied) Alpha-cell-derived INS+ cells (yellow cells) were isolated 1 month after AAV-PM (adeno-associated virus carrying pdx1 and mafA under the CMV promoter) infusion from ALX-treated GCG-Cre; R26RTomato; MIP-GFP mice, based on expression of tomato red (alpha-cell lineage) and GFP by flow cytometry. Sorted normal GFP+ beta cells and normal TOM+ alpha cells from GCG-Cre; R26RTomato; MIP-GFP mice without any treatment were used as controls.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

9 Samples

Download data: DIFF, FPKM_TRACKING

(Submitter supplied) To gain further insight into potential specific gene signatures expressed by pancreatic islet cells and pathogenic CD4+ T lymphocytes isolated from sublines of non-obese diabetic (NOD) mice expressing high or low autoimmune (type 1) diabetes incidence.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

50 Samples

Download data: TXT

(Submitter supplied) Total pancreatic RNA was isolated from 3 week old NOD.scid, NOD, BDC2.5/NOD and BDC2.5/NOD.scid animals by GITC method. Targets were produced using standard Affymetrix procedures from about 10ug total RNA. The data from NOD.scid, NOD, BDC2.5/NOD and BDC2.5/NOD.scid Affymetrix MGU74Av2 cel files was converted into Robust Multi Array (RMA) text file for analysis using GeneSpring 6.1 Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1533

Platform:

GPL81

8 Samples

Download data: CEL

Analysis of pancreas of 3-week-old BDC2.5 transgenics that express a diabetogenic T cell receptor on the NOD or NOD.scid genetic background. BDC2.5/NOD has severe insulitis. BDC2.5/NOD.scid has severe insulitis and type 1 diabetes (T1D). Result provides insight into the pathogenesis of T1D.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 disease state, 4 strain sets

Platform:

GPL81

Series:

GSE1623

8 Samples

Download data: CEL