GEO DataSets

Analysis of cochlear nucleus (CN) at postnatal days 7 (P7), 14, and 21. Deprivation of auditory nerve input from P7 to P14 results in neuron death in the anteroventral CN. Results provide insight into the molecular basis underlying this critical period of susceptibility to loss of afferent input.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL339

Series:

GSE2390

8 Samples

Download data: CEL

(Submitter supplied) Developmental differences in gene expression in the postnatal mouse cochlear nucleus was analyzed at two or three ages using two different array platforms, the Affymetrix Mouse 430A GeneChip or the NIA 15K mouse cDNA microarray. These ages, P7, P14, and P21 parallel a critical period of neuron survival dependent on input from the auditory nerve. Keywords: parallel sample

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2144

Platforms:

GPL339 GPL236

18 Samples

Download data: CEL

(Submitter supplied) We analyzed whether cochlear removal-induced transcriptional changes in the cochlear nucleus (CN) were due to loss of electrical activity in the 8th nerve. Pharmacological activity blockade of the auditory nerve for 24 h resulted in similar expression changes for only a subset of genes. Thus, an additional factor not dependent on action potential-mediated signaling must also regulate transcriptional responses to deafferentation in the CN. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

6 Samples

Download data: CEL

(Submitter supplied) Deprivation of peripheral nerve input by cochlear removal in young mice results in dramatic neuron death in the cochlear nucleus (CN). The same manipulation in older mice does not result in significant loss. The molecular basis of this critical period of vulnerability remains largely unknown. Here we identified genes regulated at early time points after cochlear removal at ages when neurons are vulnerable (postnatal day (P)7) or invulnerable (P21) to this challenge. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

44 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2227

Platform:

GPL2987

21 Samples

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(Submitter supplied) The mouse embryonic stem cell’s differentiation was guided by several treatments, and each stage of differentiation was examined. Keywords: development stage

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2987

12 Samples

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(Submitter supplied) Embryoid Bodies were dissociated and plated onto tissue culture dish in DMEM with fetal bovine serum and antibiotics for 4, 8, 12, 15, 21 day. Keywords: development stage

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2987

12 Samples

Download data

Comparison of cells induced to differentiate into dopaminergic neurons by guided differentiation (GD) to those induced to differentiate into embryoid bodies (EBs) by random differentiation (RD). Cells at 3 stages of differentiation in the GD model and days 4 to 21 EBs in the RD model compared.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 7 development stage, 2 growth protocol sets

Platform:

GPL2987

Series:

GSE5459

21 Samples

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(Submitter supplied) The cochlear nucleus is the first central pathway involved in the processing of peripheral auditory activity. It is heterogeneous in neuronal populations and physiologic responses and is organized in three major subdivisions: the anterior ventral cochlear nucleus (AVCN), the posterior ventral cochlear nucleus (PVCN) and the dorsal cochlear nucleus (DCN). Although each region demonstrates multiple cell types and functions, there are predominant populations of neurons in each region that underlie the principal role each subdivision plays in auditory processing. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by SAGE

Platform:

GPL23

3 Samples

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(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) Expression profiles in aortas isolated from mouse strains C3H.2/HeJ and C57.2Bl/6. Mice were were either on a high fat diet or normal diet for 0, 4, 10, 24, or 40 weeks. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS735

Platform:

GPL891

54 Samples

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Comparison of gene expression in aortas of C57BL/6 and C3H/HeJ fed identical high fat diets at 0, 4, 8, 24, and 40 weeks. C57BL/6 has a greater tendency than C3H/HeJ to develop atherosclerotic aortic lesions when both fed identical high fat diets.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 2 growth protocol, 2 strain, 5 time sets

Platform:

GPL891

Series:

GSE1560

54 Samples

Download data

(Submitter supplied) Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Keywords: Genetic modification

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2636

Platform:

GPL339

6 Samples

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Analysis of retinas from postnatal day 7 mutants lacking retinoschisin (RS1h), an animal model for retinoschisis (RS). RS is a recessive retinal dystrophy accompanied by macular disease often resulting in early-onset vision loss. Results provide insight into the pathogenesis of RS.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE5581

6 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL339 GPL1261

38 Samples

Download data: CEL, EXP

(Submitter supplied) 3 subtypes of cortical projection neurons were purified by fluorescence-activated cell sorting at 4 different stages of development from mouse cortex. A detailed description of the data set is described in Arlotta, P et al (2005). Keywords = corticospinal motor neuron callosal corticotectal cortex development FACS

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1076

Platform:

GPL339

19 Samples

Download data: CEL, EXP

Analysis of corticospinal motor neurons (CSMN) of C57BL/6 at embryonic day 18 to postnatal day 14. CSMN degeneration contributes to amyotrophic lateral sclerosis. CSMN compared to callosal projection and corticotectal projection neurons. Results provide insight into CSMN development.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 cell type, 4 development stage sets

Platform:

GPL339

Series:

GSE2039

19 Samples

Download data: CEL, EXP

(Submitter supplied) PURPOSE: Hyperoxia is toxic to photoreceptors, and this toxicity may be important in the progress of retinal dystrophies. This microarray study examines gene expression induced in the C57BL/6J mouse retina by hyperoxia over the 14-day period during which photoreceptors first resist, then succumb to, hyperoxia. METHODS: Young adult C57BL/6J mice were exposed to hyperoxia (75% oxygen) for up to 14 days. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

8 Samples

Download data: CEL, CHP

(Submitter supplied) Gene expression profile of Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) reveals murine targets for preclinical development of human prostate cancer therapy In this study, we have generated an open source TRAMP microarray dataset to identify differentially expressed genes from human prostate cancer that have concordant expression in TRAMP tumors, and thereby represent lead targets for preclinical therapy development. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

18 Samples

Download data: CEL