GEO DataSets

Analysis of type II activated macrophages (Mphi) generated by stimulation with lipopolysaccharide (LPS) in the presence of IgG immune complexes. Type II activated Mphi produce high levels of IL-10 and low levels of IL-12 relative to classically activated Mphi stimulated with LPS alone.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL1261

Series:

GSE4811

4 Samples

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(Submitter supplied) The purpose of this study is to identify novel markers for the type II activated macrophage, which is generated by classical stimulation in the presence if IgG immune complexes. These cells gererally produce high levels of IL-10 and low levels of IL-12, in comparison to classically activated macrophages. We wish to identify gene expression which is enriched in Type II activated macrophages in comparison to classically activated macrophages. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2041

Platform:

GPL1261

4 Samples

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(Submitter supplied) Aged humans and rodents are susceptible to infection with Streptococcus pneumoniae bacteria as a result of an inability to make antibodies to capsular polysaccharides. This is partly a result of decreased production of proinflammatory cytokines and increased production of interleukin (IL)-10 by macrophages (Mphi) from aged mice. To understand the molecular basis of cytokine dysregulation in aged mouse Mphi, a microarray analysis was performed on RNA from resting and lipopolysaccharide (LPS)-stimulated Mphi from aged and control mice using the Affymetrix Mouse Genome 430 2.0 gene chip. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

12 Samples

Download data: CEL