Similar studies for GEO DataSets (Select 200165337) - GEO DataSets

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Items: 20

Select item 2001653371.

Transcriptomic profile of melanoma clinical samples treated with BRAF and MEK- inhibitors

(Submitter supplied) To analyse the RNA expression differences between melanoma tumour samples treated with BRAF and MEK-inhibitors at different time points

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
17 Samples

Download data: TXT

Series

Accession:: GSE165337

ID:: 200165337

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001653382.

RNAseq and Small-RNAseq dataset to comprehensively study the miRNA expression profiling of drug-resistant melanoma patients and cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL24676
29 Samples

Download data: CSV, TXT

Series

Accession:: GSE165338

ID:: 200165338

PubMed Full text in PMC Similar studies

Select item 2001653353.

SmallRNAome profile of melanoma cell lines A375 and A375-BIR (BIR-BRAF INHIBITOR RESISTANT) during dabrafenib treatment

(Submitter supplied) To analyse smallRNA expression differences between A375 and A375-BIR during the treatment with dabrafenib (DAB)

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: CSV

Series

Accession:: GSE165335

ID:: 200165335

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001176664.

miRNA expression profiling of the A375 melanoma cell line and its dabrafenib-resistant A375R sub-line.

(Submitter supplied) Altered expression of miRNAs has been demonstrated in tumor tissue and plasma/serum of cancer patients. miRNAs have been shown to have both diagnostic and prognostic significance and to potentially constitute novel targets and therapeutic agents for cancer treatment. Experimental evidences also support a role of miRNAs in tumor cell response to therapy, including resistance to BRAF inhibitors (BRAFi) in melanoma. more...

Organism:: synthetic construct; Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL16384
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE117666

ID:: 200117666

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Select item 2000873315.

Distinct gene expression patterns of highly and poorly malignant melanocytic tumors from genetically engineered mouse models of mice carrying specific inactivating mutations in Ink4A or ARF respectively

(Submitter supplied) Cutaneous malignant melanoma is among the most deadly human cancers, broadly resistant to most clinical therapies. A majority of patients with BRAFV600E melanomas respond well to inhibitors such as vemurafenib, but all ultimately relapse. Moreover, there are no viable treatment options available for other non-BRAF melanoma subtypes in the clinic. A key to improving treatment options lies in a better understanding of mechanisms underlying melanoma progression, which are complex and heterogeneous. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
13 Samples

Download data: CEL, TXT

Series

Accession:: GSE87331

ID:: 200087331

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Select item 2000688416.

Gene and microRNA expression profiling of a melanoma cell line resistant to BRAF inhibitor PLX4032 compared to the parental sensitive counterpart

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL20194 GPL13938
15 Samples

Download data: TXT

Series

Accession:: GSE68841

ID:: 200068841

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Select item 2000688407.

Gene and microRNA expression profiling of a melanoma cell line resistant to BRAF inhibitor PLX4032 compared to the parental sensitive counterpart (mRNA)

(Submitter supplied) Gene and microRNA expression profiles were generated for a melanoma cell line resistant to the BRAF inhibitor PLX4032 and its parental cell line in order to identify altered gene-microRNA regulatory networks. Results showed that CCL2 acts as an autocrine factor and coordinately regulates, via HIF1, miR-34a, miR-100 and miR-125b, which are involved in cell proliferation and apoptosis. Inhibition of CCL2 and of the specific miRNAs restores sensitivity to BRAF inhibitors.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13938
7 Samples

Download data: TXT

Series

Accession:: GSE68840

ID:: 200068840

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Select item 2000688398.

Gene and microRNA expression profiling of a melanoma cell line resistant to BRAF inhibitor PLX4032 compared to the parental sensitive counterpart (miRNA)

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL20194
8 Samples

Download data: TXT

Series

Accession:: GSE68839

ID:: 200068839

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Select item 2001075769.

miR-204-5p and miR-211-5p contribute to BRAF inhibitor resistance in melanoma

(Submitter supplied) Purpose: Identification of miRNAs that enable resistance to BRAF inhibitors in melanoma suggests a mechanism-based strategy to limit resistance and improve clinical outcomes. Methods: We generated A375 melanoma cells resistant to Vemurafenib (VMF) with the goal of investigating changes in miRNA expression patterns that might contribute to resistance. Results: Increased expression of miR-204-5p and miR-211-5p occurring in VMF-resistant cells was determined to impact VMF response.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: CSV

Series

Accession:: GSE107576

ID:: 200107576

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002565310.

miRNA profiling of Melanoma Cell lines and Normal Melanocytes

(Submitter supplied) To identify microRNAs potentially involved in melanomagenesis we compared microRNA transcription profiles between melanoma cell lines and cultured melanocytes.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL6955
56 Samples

Download data: TXT

Series

Accession:: GSE25653

ID:: 200025653

Select item 20004127411.

TGF-beta-mediated microRNA expression in breast cancer cells

(Submitter supplied) We utilized 3D-organotypic cultures whose physical properties were altered by inclusiong of type I collagen to create biomechanically rigid microenvironments that approximated those typically observed in primary mammary tumors. Compliant 3D-organotypic cultures were also generated to recapitulate the biomechanical properties of pulmonary microenvironments typically encountered by disseminated breast carcioma cells. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL16125
24 Samples

Download data: TXT

Series

Accession:: GSE41274

ID:: 200041274

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Select item 20005872112.

BRAF inhibition leads to oxidative phosphorylation and cellular senescence in human melanoma cells

(Submitter supplied) Targeting components of the mitogen-activated protein kinase (MAPK) pathway prolongs survival of patients with advanced BRAFV600E melanomas but such an approach is not curative because of the rapid acquisition of numerous resistance mechanisms. Here we analyze melanoma cells that evade MAPK inhibitors by undergoing a senescence-like, slow-growth, phenotype, which leads to acquired resistance. The initial therapeutic response is characterized by an integrated stress response program, including stimulation of autophagic flux, activation of the endoplasmic reticulum machinery, and an enhanced ability of detoxifying reactive oxygen species. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
14 Samples

Download data: TXT

Series

Accession:: GSE58721

ID:: 200058721

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010937813.

MicroRNA (miR)-211 loss promotes metabolic vulnerability and BRAF inhibitor sensitivity in melanoma

(Submitter supplied) We report that miR-211 loss-of-function in the pigmented melanoma cell line SKMEL-28 slowed growth and invasion in vitro, inhibited phosphoinositol-3-kinase (PI3K) signaling, rendered these melanoma cells metabolically vulnerable by attenuating mitochondrial respiration and tricarboxylic acid (TCA) cycling and inhibited melanoma growth in vivo.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT

Series

Accession:: GSE109378

ID:: 200109378

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Select item 20002932714.

Gene expression profiling of MCF10A (miR-221/222 vs control)

(Submitter supplied) Analysis of gene expression of MCF10A to identify the targets of miR-221 and miR-222 Keywords: MCF10, miR-221, miR-222

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4797
Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE29327

ID:: 200029327

Select item 20001279015.

Gene expression profiling of human breast cancers and cancer cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
98 Samples

Download data: CEL

Series

Accession:: GSE12790

ID:: 200012790

Select item 20001277716.

Gene expression profiling of 51 human breast cancer cell lines

(Submitter supplied) Basal gene expression levels were determined by global gene expression profiling of breast cancer cell lines. Molecular subtype was determined using gene expression and HER2 status assesses by HER2 FISH analysis. Keywords: Basal gene expression (no stimulation or timecourse)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
51 Samples

Download data: CEL

Series

Accession:: GSE12777

ID:: 200012777

Select item 20001276417.

Gene expression changes upon expression of activated versions of MEK1 and HRAS in MCF10A cells

(Submitter supplied) MCF10A cells were then transfected with MEK1(S217S221), HRAS(G12V), and null control vectors Cells were lysed 24 hours post-transfection with collection of total RNA and protein Keywords: Oncogene inducation of gene expression changes

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
17 Samples

Download data: CEL

Series

Accession:: GSE12764

ID:: 200012764

Select item 20001276318.

Gene expression profiling of 30 human breast cancers

(Submitter supplied) We used microarrays to profile 30 human primary breast tumors and determine global gene expression patterns and molecular subtypes Keywords: Basal gene expression in human tumor samples