GEO DataSets

(Submitter supplied) Glioblastoma is a high-grade glial neoplasm with a patient survival of 12-18 months. Therefore, there is an urgent need for identification of novel therapeutic targets. RAB38 is a member of a family of small GTPase proteins and has been implicated in regulating cell proliferation and survival in tumors. The role of RAB38 in glioblastoma is unexplored. Here, we used human glioblastoma cell lines to test the hypothesis that RAB38 regulates glioblastoma growth. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

4 Samples

Download data: CEL

(Submitter supplied) U87 cells were transduced with IDH1 WT or IDH1 R132H and stable clones were selected.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

2 Samples

Download data: CEL

(Submitter supplied) We performed microarray analysis in order to evaluate the effect of ONC201 and its derivatives (ONC206 and ONC212) on gene expression in U87 glioma cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

4 Samples

Download data: CEL

(Submitter supplied) We performed microarray analysis in order to evaluate the effect of ONC201 on gene expression in glioma cells (U87).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

2 Samples

Download data: CEL

(Submitter supplied) We identified GSK3 as a regulator of GBM cell survival using microarray analysis, small molecule and genetic inhibitors of GSK3 activity. Various molecular and genetic approaches were then employed to dissect out the molecular mechanisms responsible for GSK3 inhibition-induced cytotoxicity. Keywords: time course

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

18 Samples

Download data: CEL

(Submitter supplied) Bcl-xL is an anti-apoptotic protein that is frequently found to be overexpressed in non-small cell lung cancer leading to an inhibition of apoptosis and poor prognosis. Recently, the role of miRNAs in regulating apoptosis and cell survival during tumorigenesis has become evident, with cancer cells showing perturbed expression of various miRNAs. We utilized miRNA microarrays to determine if miRNA dysregulation in bcl-xL silenced lung adenocarcinoma cells could be involved in regulating apoptotic behavior, and identified dysregulated miRNAs with putative targets involved in signal transduction pathways regulating apoptosis, cell proliferation and cell progression.

Organism:

Homo sapiens; synthetic construct

Type:

Non-coding RNA profiling by array

Platform:

GPL8786

6 Samples

Download data: CEL