GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL10999

110 Samples

Download data

(Submitter supplied) Daily sampling of peripheral blood from human subjects vaccinated for influenza was done immediately before vaccination and for 10 days after vaccination. Temporal patterns of gene expression, determined by RNA-seq, in unfractionated PBMC suggested migration of myeloid/dendritic cell lineage cells one day after vaccination.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL10999

55 Samples

Download data: TXT

(Submitter supplied) Daily sampling of peripheral blood from human subjects vaccinated for influenza was done immediately before vaccination and for 10 days after vaccination. In B cells, 90% of transcriptomic variation in subjects who received influenza vaccine within the previous three years was explained by a single temporal pattern unique to the individual. A common set of 742 genes was strongly correlated with the migration of differentiating plasma cell subtypes.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL10999

55 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

228 Samples

Download data

(Submitter supplied) We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

156 Samples

Download data: TXT

(Submitter supplied) We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

72 Samples

Download data: TXT

(Submitter supplied) We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

79 Samples

Download data: TXT

(Submitter supplied) We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

98 Samples

Download data: TXT

(Submitter supplied) We profiled gene expression of B and T cells from a stratified cohort of subjects to define influenza vaccine response in Young and Old

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

236 Samples

Download data: TXT

(Submitter supplied) We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

356 Samples

Download data: TXT

(Submitter supplied) We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

215 Samples

Download data: TXT

(Submitter supplied) A major goal of systems biology is the development of models that accurately predict responses to perturbation. Constructing such models requires the collection of dense measurements of system states, yet transformation of data into predictive constructs remains a challenge. To begin to model human immunity, we analyzed immune parameters in depth both at baseline and in response to influenza vaccination. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

292 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13158

621 Samples

Download data: CEL, CHP

(Submitter supplied) Systems approaches have been used to describe molecular signatures driving immunity to influenza vaccination in humans. Whether such signatures are similar across multiple seasons, and in diverse populations is unknown. We applied systems approaches to study immune responses in young and, elderly subjects vaccinated with the seasonal influenza vaccine across 5 consecutive seasons.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13158

177 Samples

Download data: CEL, CHP

(Submitter supplied) Systems approaches have been used to describe molecular signatures driving immunity to influenza vaccination in humans. Whether such signatures are similar across multiple seasons, and in diverse populations is unknown. We applied systems approaches to study immune responses in young and, elderly subjects vaccinated with the seasonal influenza vaccine across 5 consecutive seasons.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13158

75 Samples

Download data: CEL, CHP

(Submitter supplied) Systems approaches have been used to describe molecular signatures driving immunity to influenza vaccination in humans. Whether such signatures are similar across multiple seasons, and in diverse populations is unknown. We applied systems approaches to study immune responses in young and, elderly subjects vaccinated with the seasonal influenza vaccine across 5 consecutive seasons.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13158

286 Samples

Download data: CEL, CHP

(Submitter supplied) Systems approaches have been used to describe molecular signatures driving immunity to influenza vaccination in humans. Whether such signatures are similar across multiple seasons, and in diverse populations is unknown. We applied systems approaches to study immune responses in young and, elderly subjects vaccinated with the seasonal influenza vaccine across 5 consecutive seasons.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13158

83 Samples

Download data: CEL, CHP

(Submitter supplied) Systems biology is an approach to comprehensively study complex interactions within a biological system. Most published systems vaccinology studies have utilized whole blood or peripheral blood mononuclear cells (PBMC) to monitor the immune response after vaccination. Because human blood is comprised of multiple hematopoietic cell types, the potential for masking responses of under-represented cell populations is increased when analyzing whole blood or PBMC. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

56 Samples

Download data: TXT

(Submitter supplied) While studying influenza vaccine-induced responses, the elderly are typically considered as a homogeneous population. However, chronological age alone is insufficient in defining immune responsiveness of individuals. In this study, a stratified cohort of elderly (65 year old and above) and young (below 35 year old) individuals was recruited to study the heterogeneity of influenza vaccine-induced responses and identify innate signatures including gene expression profiles defining vaccine immunogenicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

671 Samples

Download data: IDAT, TXT

(Submitter supplied) Clinical data showed sex variability in the immune response to influenza vaccination, this study aimed to investigate differentially expressed genes that contribute to sex-bias immune responses to quadrivalent inactivated influenza vaccines (QIVs) in older subjects. A cohort of 60 healthy older adults aged 60 to 80 years old were vaccinated with quadrivalent inactivated influenza vaccines (QIVs), and gene expression was analyzed at Day 0 pre-vaccination, Day 3, Day 28 and Day 180 post-vaccination. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

63 Samples

Download data: TXT