GEO DataSets

Temporal analysis of right ventricles at the onset of compensated or decompensated right ventricular hypertrophy. Compensated and decompensated phenotypes induced by injection with 30 and 80 mg/kg monocrotaline, respectively. Results identify potential prognostic markers and therapeutic targets.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log2 ratio, 3 disease state, 3 time sets

Platform:

GPL1397

Series:

GSE3675

27 Samples

Download data: IMAGENE

(Submitter supplied) We recently introduced a modification of the established monocrotaline (MCT) model for pulmonary hypertension (PH) and subsequent right ventricular (RV) hypertrophy, which allows for the selective induction of either a compensate or decompensated RV hypertrophic phenotype within four weeks after a single subcutaneous MCT injection. Both doses of 30 or 80 mg/kg body weight lead to an intermediate phase of compensated RV hypertrophy (day 14-19), while the former dose leads to a stable compensated phenotype (HYP) and the latter dose progresses towards decompensated ventricular hypertrophy and RV failure (CHF) around day 25-28 (Buermans et. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1928

Platform:

GPL1397

27 Samples

Download data: IMAGENE

(Submitter supplied) 14 days after a single subcutaneous monocrotaline (MCT) injection we isolated the left and right ventricles from wistar rats. Factor1: Comparison between control (CON), compensated hypertrophy (HYP), and decompensated hypertrophy (CHF). Factor2: Comparison between left ventricle (LV) and right ventricle (RV). Keywords: dose response

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS742

Platform:

GPL1397

24 Samples

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Analysis of compensated and decompensated hypertrophies induced by monocrotaline in Wistar. Left and right heart ventricles examined 14 days after monocrotaline injection. Decompensated hypertrophy is a prelude to chronic heart failure.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 3 disease state, 2 tissue sets

Platform:

GPL1397

Series:

GSE1652

24 Samples

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(Submitter supplied) Cardiac hypertrophy was induced by treadmill running. Sedentary animals served as controls. Gene expression was determined by Affymetrix RGU34A GeneChip's to identify genes with differential expression in an adaptive model of cardiac hypertrophy. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS654

Platform:

GPL85

12 Samples

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Analysis of heart left ventricles from animals subjected to 7 weeks treadmill exercise compared with sedentary controls. Provides insight into molecular mechanisms of left ventricular hypertrophy.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL85

Series:

GSE739

12 Samples

Download data

(Submitter supplied) Background: Right ventricular (RV) and left ventricular (LV) myocardium differ in their response to pressure-overload hypertrophy (POH). In this report we use microarray and proteomic analyses to identify pathways modulated by LV-, and RV-POH in the immature heart. Methods: Newborn New Zealand White rabbits underwent banding of the descending thoracic aorta (LV-POH; n=6). RV-POH was achieved by banding the pulmonary artery (n=6). more...

Organism:

Oryctolagus cuniculus

Type:

Expression profiling by array

Platform:

GPL13758

6 Samples

Download data: GPR

(Submitter supplied) 6 timepoints: Day 0 (normal controls), progressively developing neointimal vascular proliferation and pulmonary hypertension in vehicle treated animals (Days 14, 21, 28 and 35) and triptolide-treated animals at Day 35. Replicates: 6 for Day 0 (normal) 2 for Daty 14 3 each for Days 21, 28, 35 and Triptolide -treated at day 35 (T) Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL153

20 Samples

Download data

(Submitter supplied) We employed the Affymetrix GeneChip technology to evaluate the patterns of expression in two different in vivo models of cardiac remodeling and in two different regions (left ventricle free wall and septum) of the heart. Mice underwent transverse aortic constriction (TAC); myocardial infarction (MI) or Sham operation and RNA from the left ventricle free wall and the septum was isolated 1 week later. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS387 GDS388

Platforms:

GPL75 GPL76

36 Samples

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Evaluation of in vivo models of cardiac remodeling. Mice underwent transverse aortic constriction (TAC); myocardial infarction (MI) or sham operation. Left ventricle free wall and septum tissues examined 1 week later.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol, 2 tissue sets

Platform:

GPL76

Series:

GSE415

18 Samples

Download data

Evaluation of in vivo models of cardiac remodeling. Mice underwent transverse aortic constriction (TAC); myocardial infarction (MI) or sham operation. Left ventricle free wall and septum tissues examined 1 week later.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol, 2 tissue sets

Platform:

GPL75

Series:

GSE415

18 Samples

Download data

(Submitter supplied) The right ventricle (RV) differs in several aspects from the left ventricle (LV) including its embryonic origin, physiological role and anatomical design. In contrast to LV hypertrophy, little is known about the molecular circuits, which are activated upon RV hypertrophy (RVH). We established a highly reproducible model of RVH in mice using pulmonary artery clipping (PAC), which avoids detrimental RV pressure overload and thus allows long-term survival of operated mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4545

Platform:

GPL6246

12 Samples

Download data: CEL

Analysis of right ventricle (RV) from C57BL/6 males subjected to hemoclip installation around the pulmonary artery (PA) for up to 6 weeks. PA clipping induces RV hypertrophy (RVH) while avoiding detrimental RV pressure overload. Results provide insight into the molecular basis of RV remodeling.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 protocol, 3 time, 2 tissue sets

Platform:

GPL6246

Series:

GSE30428

12 Samples

Download data: CEL

(Submitter supplied) To investigate molecular mechanisms involved in the development of cardiac hypertrophy and heart failure, a tetracycline-regulated transgenic system to conditionally switch a constitutively-active form of the Akt1 protein kinase on or off in the adult heart was developed. Short-term activation (2 weeks) of Akt1 resulted in completely reversible hypertrophy with maintained contractility. In contrast, chronic Akt1 activation (6 weeks) induced extensive cardiac hypertrophy, severe contractile dysfunction, and massive interstitial fibrosis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS2304 GDS2308

Platforms:

GPL339 GPL340

36 Samples

Download data

Analysis of hearts after acute or chronic induction of a transgenic Akt1 kinase. Acute activation results in reversible hypertrophy, while chronic activation induces transition to failure. Results provide insight into the mechanisms involved in the development of cardiac hypertrophy and failure.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 protocol sets

Platform:

GPL340

Series:

GSE3383

18 Samples

Download data

Analysis of hearts after acute or chronic induction of a transgenic Akt1 kinase. Acute activation results in reversible hypertrophy, while chronic activation induces transition to failure. Results provide insight into the mechanisms involved in the development of cardiac hypertrophy and failure.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 protocol sets

Platform:

GPL339

Series:

GSE3383

18 Samples

Download data

(Submitter supplied) Expression profiling of hearts from FVB males subjected to cardiac pressure overload by transverse aortic constriction (TAC). TAC performed on 8-10 weeks month old males and females. Hearts examined 30 weeks after surgery. Keywords: ordered

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2258

Platform:

GPL81

15 Samples

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Analysis of heart left ventricles (LVs) of animals with pressure overload LV hypertrophy (LVH) caused by transverse aortic constriction. Pressure overload on the heart resulting from chronic hypertension or aortic stenosis is a stimulus for LVH. Results provide insight into the pathogenesis of LVH.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 gender sets

Platform:

GPL81

Series:

GSE2459

15 Samples

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(Submitter supplied) We used transverse aortic constraction pressure overload hypertrophy mouse hearts as a model of cardiovascular disease to study the genetic changes between TAC and SHAM (normal) mouse hearts and over 1 circadian cycle (24h). This is one approach to identify diurnal genetic biomarkers of cardiovascular disease. The micorarray approach allowed to see the gene expression in all genes in cardiovascular disease and sham hearts.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

36 Samples

Download data: CEL, CHP

(Submitter supplied) Rats overexpressing the human renin and angiotensinogen genes die after seven weeks of end organ damage. They develop hypertension, heart hypertrophy and proteinuria.We compared terminal heart failure, these are indeed terminally ill to double transgenic animals suffering on hypertension, proteinuria and heart hypertrophy. In addition, Losartan-treated animals (10 mg/kg/d)showed similar physiological parameters (normotension, no proteinuria and no heart hypertrophy compared to control sprague dawley rats. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1049

Platform:

GPL85

4 Samples

Download data: CEL, EXP