GEO DataSets

Analysis of the amygdalae and hippocampi of lines exhibiting high or low freezing behavior in response to fear. The amygdala and hippocampus are brain regions important in fear behavior. Results provide insight into the genetic basis of fear behavior.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL1261

Series:

GSE4035

24 Samples

Download data: CEL

(Submitter supplied) These data are from the brains (amygdala and hippocampus) of mice originally derived from a cross between C57BL/6J and DBA/2J inbred strains. We used short-term selection to produce outbred mouse lines with differences in contextual fear conditioning, which is a measure of fear learning. We selected for a total of 4 generations. Fear learning differed in the selected lines and this difference was stronger with each successive generation of selection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1921

Platform:

GPL1261

24 Samples

Download data: CEL

(Submitter supplied) These data are from the brains (amygdala and hippocampus) of mice originally derived from a cross between C57BL/6J and A/J inbred strains. We used short-term selection to produce outbred mouse lines with differences in contextual fear conditioning, which is a measure of fear learning. We selected for a total of 4 generations. Fear learning differed in the selected lines and this difference was stronger with each successive generation of selection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1901

Platform:

GPL1261

24 Samples

Download data: CEL

Analysis of the amygdalae and hippocampi of strains exhibiting low or high freezing behavior in response to fear. Previous work identified alleles that contribute to the variability in freezing behavior, and the chromosomal location of these alleles.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL1261

Series:

GSE4034

24 Samples

Download data: CEL

(Submitter supplied) Hippocamus and amygdala expression was examined in naïve, conditioned stimulus exposed, and fear conditioned mice 30 minutes after behavioral manipulation Keywords: comparison of 3 groups x 2 brain regions

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1903

Platform:

GPL81

48 Samples

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Comparison of amygdalae and hippocampi of animals subjected to classical fear conditioning (CFC), which consists of a 3-minute exposure to the conditioning chamber, a 30-second exposure to tone, and a 2-second, 1.5-mA footshock. CFC induced greater gene expression changes in the amygdala.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol, 2 tissue sets

Platform:

GPL81

Series:

GSE3963

48 Samples

Download data

(Submitter supplied) The early-life environment critically influences neurodevelopment and later psychological health. To elucidate neural and environmental elements that shape emotional behavior, we developed a rat model of individual differences in temperament and environmental reactivity. We selectively bred rats for high versus low behavioral response to novelty and found that high-reactive (bred high-responder, bHR) rats displayed greater risk-taking, impulsivity and aggression relative to low-reactive (bred low-responder, bLR) rats, which showed high levels of anxiety/depression-like behavior and certain stress vulnerability. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL19519

160 Samples

Download data: PAIR

(Submitter supplied) Catechol-O-methyltransferase (COMT) is an ubiquitously expressed enzyme that maintains basic biologic functions by inactivating catechol substrates. In humans, polymorphic variance at the COMT locus has been associated with modulation of pain sensitivity (Andersen & Skorpen, 2009) and risk for developing psychiatric disorders (Harrison & Tunbridge, 2008). A functional haplotype associated with increased pain sensitivity was shown to result in decreased COMT activity by altering mRNA secondary structure-dependent protein translation (Nackley et al., 2006). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

56 Samples

Download data: CEL

(Submitter supplied) To uncover genetic networks governing the biology of conditional fear, we used a systems genetics approach to analyze a hybrid mouse diversity panel (HMDP) with high mapping resolution. By integrating fear phenotypes, transcript profiling data from hippocampus and striatum and genotype information, two gene co-expression networks correlated with context-dependent immobility were identified. We prioritized the key markers and genes in these pathways using intramodular connectivity measures and structural equation modeling. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3900

Platform:

GPL6885

198 Samples

Download data: TXT

Analysis of whole hippocampus and striatum from Hybrid Mouse Diversity Panel (HMDP) males exposed to a fear conditioning procedure. The HMDP panel 29 classical inbred strains and 71 recombinant inbred strains. Results provide insight into molecular mechanisms underlying fear phenotypes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 100 strain, 2 tissue sets

Platform:

GPL6885

Series:

GSE26500

198 Samples

Download data

(Submitter supplied) By using RNA sequencing (RNA-seq), we analyzed gene expression profiles in the cortex and hippocampus of the adult brain to demonstrate the molecular mechanisms of radiation-induced brain dysfunction.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

12 Samples

Download data: TXT

(Submitter supplied) Purpose: To investigate the effect that selective breeding for high and low OFA has on gene expression Methods: Male and female High and Low Activity mice (n=4 per strain/sex) were euthanized at postnatal day 70 and hippocampi were immediately collected. Paired-end RNA-seq methods were employed to assess hippocampal mRNA expression. Results: The expression of thousands of transcripts were altered by selective breeding for high and low OFA.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

16 Samples

Download data: XLSX