GEO DataSets

Analysis of pancreatic islets from 6 to 8 week old Tcf1 knockouts. Mutations in Tcf1 lead to a subtype of type 2 diabetes called maturity-onset diabetes of the young (MODY) in humans. Results identify potential targets of Tcf1 that may be responsible for mediating pancreatic beta cell growth.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL82

Series:

GSE3544

4 Samples

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(Submitter supplied) Expression profiling of pancreatic islets in Tcf1 knock out mice Keywords: repeat sample serie

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1473 GDS1474

Platforms:

GPL81 GPL82

8 Samples

Download data

Analysis of pancreatic islets from 6 to 8 week old Tcf1 knockouts. Mutations in Tcf1 lead to a subtype of type 2 diabetes called maturity-onset diabetes of the young (MODY) in humans. Results identify potential targets of Tcf1 that may be responsible for mediating pancreatic beta cell growth.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL81

Series:

GSE3544

4 Samples

Download data

(Submitter supplied) We set out to identify differences in the transcriptome influenced by knockout of the transcription factor T-cell factor 7 (Tcf7) in mouse islets. Furthermore, we wanted to determine if metabolic stress (age,diet) influences these changes. Therefore, we compared the islet transcriptome from WT and Tcf7-/- mice both at a young age (8 weeks old) fed a low fat (10%) diet, versus WT and Tcf7-/- mice at an old age (20 weeks old) on a high-fat (45%) diet.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

8 Samples

Download data: XLS

(Submitter supplied) Transcriptome analysis reveals that in pancreatic beta cells weaning increases the expression of genes involved in replication licensing, suggesting a mechanism to increased responsiveness to the mitogenic activity of high glucose.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

7 Samples

Download data: CEL

(Submitter supplied) We report changes in gene expression in mouse islets that express c-MYC in pancreatic beta cells as compared to control cells that lack such ectopic expression. The goal of the study is to identify the MYC-dependent changes that occur in beta cells that affect cellular fate and function.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

6 Samples

Download data: TXT