GEO DataSets

Expression profiling of lesioned retina at various time points up to 14 days after injury. Results provide insight into the molecular mechanisms that enable the regeneration of injured retinas in adult anamniotes.

Organism:

Danio rerio

Type:

Expression profiling by array, count, 4 disease state, 3 protocol, 6 time, 2 tissue sets

Platform:

GPL1319

Series:

GSE3303

12 Samples

Download data

(Submitter supplied) Purpose: Investigate the molecular determinants of retinal regeneration in adult vertebrates by analyzing the gene expression profiles of control and post-lesion retina of adult zebrafish, a system that regenerates following injury. Methods: Gene expression profiles of zebrafish retina and brain were determined with DNA microarray, RT-PCR, and real-time quantitative PCR analyses. Damaged retinas and their corresponding controls were analyzed 2-5 days post-lesion (acute injury condition) or 14 d post-lesion (cell regeneration condition). more...

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS1404

Platform:

GPL1319

12 Samples

Download data

(Submitter supplied) To gain a better understanding of the factors necessary for successful CNS regeneration, a temporal analysis of the changes in gene expression in the eye caused by optic nerve injury was conducted. Dual color oligonucleotide microarrays were used to compare total RNA harvested from the eyes of sham-operated and optic nerve-injured fish at 3, 24, and 168 hours following surgery. Optic nerve injured fish are compared to sham-operated fish in order to eliminate gene expression due to non-neuronal damage and inflammatory response. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL9117

4 Samples

Download data: TXT

(Submitter supplied) Using a canine custom retinal cDNA microarray our aim is to identify normal gene expression profiling for retina and frontal, occipital and temporal brain cortices Keywords: retina-brain comparisons

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platforms:

GPL3951 GPL3957

11 Samples

Download data

(Submitter supplied) GPL9743 represents two different print sets, v1 and v2. While the order of the clones are not exactly the same in v1 and v2, the clones themselves are identical. The Platform data table reflects a condensed representation of the print sets' replicate features. The v1 and v2 full array layout (.gal) files, representing all of the individual features, are linked below as supplementary files. Protocol: EST clones were obtained from a normalized canine retinal library cloned into pGEM 11ZF(+) vector (Promega). more...

Organism:

Canis lupus familiaris

1 Series

12 Samples

Download data: GAL

(Submitter supplied) Purpose: The DBA/2J mouse is a model for secondary angle-closure glaucoma due to iris atrophy and pigment dispersion, which ultimately leads to increased intraocular pressure (IOP). We sought to correlate changes in retinal gene expression with glaucoma-like pathology by performing microarray analysis of retinal RNA from DBA/2J mice at 3 months before disease onset, and at 8 months, after IOP elevation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1728

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of retinas from strain DBA/2J with elevated intraocular pressure (IOP). A model for glaucoma, DBA/2J has mutations that lead to iris atrophy and pigment dispersion. These conditions result in increased IOP. Results provide insight into the molecular changes associated with IOP elevation.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 2 disease state sets

Platform:

GPL1261

Series:

GSE3554

6 Samples

Download data: CEL

(Submitter supplied) Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Keywords: Genetic modification

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2636

Platform:

GPL339

6 Samples

Download data

Analysis of retinas from postnatal day 7 mutants lacking retinoschisin (RS1h), an animal model for retinoschisis (RS). RS is a recessive retinal dystrophy accompanied by macular disease often resulting in early-onset vision loss. Results provide insight into the pathogenesis of RS.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE5581

6 Samples

Download data

(Submitter supplied) The zebrafish (Danio rerio) embryo toxicity test (DarT) is considered as an alternative to the acute fish toxicity test. However, DarT rarely reveals information on the mechanisms underlying a toxic effect and is relatively insensitive compared to chronic toxic effects. We hypothesized that, by using gene expression profiles as an additional endpoint, it may be possible to increase the sensitivity and predictive value of DarT. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL4518

6 Samples

Download data: MEV

(Submitter supplied) Consistent with clinical observations that posterior uveitis frequently involves the retinal vasculature and recent recognition of vascular heterogeneity, we hypothesized that retinal vascular endothelium was a cell population of unique molecular phenotype. Donor-matched cultures of primary retinal and choroidal endothelial cells from 6 human cadavers were incubated with either Toxoplasma gondii tachyzoites (10:1, parasite:cell) or Escherichia coli lipopolysaccharide (100 ng/mL); control cultures were simultaneously incubated with medium. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

46 Samples

Download data: CEL

(Submitter supplied) Ischemic cardiopathy is the leading cause of death in the world, for which efficient regenerative therapy is not currently available. In mammals, after a myocardial infarction episode, the damaged myocardium is replaced by scar tissue featuring collagen deposition and tissue remodelling with negligible cardiomyocyte proliferation. Zebrafish, in contrast, display an extensive regenerative capacity as they are able to restore completely lost cardiac tissue after partial ventricular amputation. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS3623

Platform:

GPL1319

15 Samples

Download data: CEL

Analysis of hearts of zebrafish 1 to 7 days following partial heart amputation. Unlike mammals, zebrafish hearts display an extensive regenerative capacity. Results provide insight into the molecular basis of this regenerative capacity.

Organism:

Danio rerio

Type:

Expression profiling by array, transformed count, 2 protocol, 5 time sets

Platform:

GPL1319

Series:

GSE17993

15 Samples

Download data: CEL

(Submitter supplied) Characterization of the zebrafish embryonic host response to systemic bacterial infection with Salmonella typhimurium wild type strain (SL1027) and its isogenic LPS O-antigen mutant Ra (SF1592) by means of a time-resolved global expression analysis.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL7735

36 Samples

Download data: XML

(Submitter supplied) The alkylating agent N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) induces cellular DNA damages and other comprehensive alterations that lead to chromosomal aberrations, mutations, tumor initiations, and cell death. However, the molecular mechanism of MNNG-induced cellular stress remains unclear.We have genome-wide analyzed early transcriptional responses of human FL amnion epithelial cells after exposure to three relatively low doses of MNNG (0.2, 1.0, and 10.0µM),and differential gene expression profiles were obtained 4 h after exposure using oligonucleotide microarrays followed by validation with quantitative real-time RT-PCR. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

16 Samples

Download data: CEL, EXP

(Submitter supplied) Sexual reproduction is a complex process involving multiple pathways. In this study, we aimed at investigating gene expression profiles underlying gender specificity in the zebrafish. To do so, we analyzed the transcriptome of the gonads of breeding fish and queried the gene expression profiles for significant differences between the genders and also between stages of gonad development. Major differences in gene expression profiles between genders were encountered at the level of the gonads. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL4375

11 Samples

Download data: TXT

(Submitter supplied) Teleost fish have the remarkable ability to regenerate their body parts including heart, spinal cord, and the caudal fin, while many higher vertebrates including us humans have only a limited ability. To facilitate molecular and genetic approaches for regeneration, we previously established an assay using the fin fold of early stage larvae, which regenerate their caudal fin folds as in adult regeneration. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platforms:

GPL530 GPL531

4 Samples

Download data: TXT

(Submitter supplied) To study gene expression changes in the rat retina and choroid following transpupillary thermotherapy (TTT) and to identify molecular mechanisms that may enhance treatment of choroidal neovascularization, complicating age-related macular degeneration. Keywords: Expression level alteration in the rat retina and choroid after TTT

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL882

2 Samples

Download data: GPR

(Submitter supplied) Sprague-Dawley rat retina post-injury and control samples Keywords = Gliosis, CNS injury

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS656

Platform:

GPL85

18 Samples

Download data

Examination of injured retinas from male Sprague-Dawleys. Retinas scraped and examined at 4 hours, 1, 3, 7, and 30 days post-injury. Results help characterize distinct phases of retinal injury response.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol, 6 time sets

Platform:

GPL85

Series:

GSE1001

18 Samples

Download data