Similar studies for GEO DataSets (Select 1339) - GEO DataSets

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Items: 10

Select item 13391.

T cell anergy induction regulation by Egr-2 and Egr-3 (MG-U74C)

Analysis of pooled mRNA (2, 4, 6 hours) from A.E7 T cell clones activated in conditions that promote (anti-TCR) or inhibit (anti-TCR + CsA or PKCi or Combo) anergy induction. Results identify the early growth response gene 2 (Egr-2) and Egr-3 as key positive regulators of T cell anergy induction.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 5 agent, 3 protocol sets

Platform:: GPL83
Series:: GSE2323
5 Samples

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DataSet

Accession:: GDS1339

ID:: 1339

Select item 2000023232.

Anergy Induction

(Submitter supplied) pooled mRNA (2, 4, 6 hrs) from A.E7 T cells under conditions which promote or inhibit anergy induction Keywords: ordered

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS1336 GDS1338 GDS1339
Platforms:: GPL82 GPL83 GPL81
15 Samples

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Series

Accession:: GSE2323

ID:: 200002323

Select item 13383.

T cell anergy induction regulation by Egr-2 and Egr-3 (MG-U74B)

Organism:: Mus musculus

Type:: Expression profiling by array, count, 5 agent, 3 protocol sets

Platform:: GPL82
Series:: GSE2323
5 Samples

Download data

DataSet

Accession:: GDS1338

ID:: 1338

Select item 13364.

T cell anergy induction regulation by Egr-2 and Egr-3 (MG-U74A)

Organism:: Mus musculus

Type:: Expression profiling by array, count, 5 agent, 3 protocol sets

Platform:: GPL81
Series:: GSE2323
5 Samples

Download data

DataSet

Accession:: GDS1336

ID:: 1336

Select item 2001671695.

RNA sequencing of T cells in the genetically encoded mouse model of T cell anergy (W131AOTII)

(Submitter supplied) We found that gene signatures characteristic of unresponsive cells were strongly enriched in peripheral W131AOTII CD4 T cells but not in CD4 single positive (CD4SP) thymocytes. Furthermore, loss of Cbl-b in W131AOTII mice significantly altered gene expression profile associated with improved T cell responsiveness.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
18 Samples

Download data: TXT

Series

Accession:: GSE167169

ID:: 200167169

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000727316.

Kinetic analysis of T cell anergy induction

(Submitter supplied) T cell receptor(TCR) engagement in the absence of costimulation leads to a state of T cell tolerance known as anergy. Anergy induction requires new protein synthesis since it is inhibited by cycloheximide. In this experiment, we tried to figure out kinetic properties of the gene expression in anergy induction phase and the subsequent anergy maintenance phase.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL83 GPL81 GPL82
15 Samples

Download data: CEL

Series

Accession:: GSE72731

ID:: 200072731

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000462437.

Role of EGR2 transcription factor in T cell anergy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL9185 GPL1261
15 Samples

Download data: BED, CEL, CHP

Series

Accession:: GSE46243

ID:: 200046243

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000462428.

Egr2-dependent expression in T cell anergy

(Submitter supplied) T cell anergy is one of the mechanisms contributing to peripheral tolerance, particularly in the context of progressively growing tumors and in tolerogenic treatments promoting allograft acceptance. We recently reported that early growth response gene 2 (Egr2) is a critical transcription factor for the induction of anergy in vitro and in vivo, which was identified based on its ability to regulate the expression of inhibitory signaling molecules diacylglycerol kinase (DGK)-a and -z. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE46242

ID:: 200046242

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000462419.

Genome-wide maps of EGR2 transcription factor binding sites in T cell anergy

(Submitter supplied) We report the application of sequencing technology for mapping the EGR2 transcriptional program in T cell anergy

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9185
3 Samples

Download data: BED

Series

Accession:: GSE46241

ID:: 200046241

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008621010.

Expression data of CLL cells with and without NFAT2 expression

(Submitter supplied) Chronic lymphocytic leukemia (CLL) is a disorder of mature B cells. Most patients are characterized by indolent disease and an anergic phenotype of their leukemia cells which refers to a state of unresponsiveness to B cell receptor stimulation. Using the Eµ-TCL1 mouse model, we show that B cell-specific ablation of NFAT2 leads to the loss of the anergic phenotype culminating in a significantly compromised life expectancy and histological transformation to aggressive disease. more...