GEO DataSets

Analysis of corticospinal motor neurons (CSMN) of C57BL/6 at embryonic day 18 to postnatal day 14. CSMN degeneration contributes to amyotrophic lateral sclerosis. CSMN compared to callosal projection and corticotectal projection neurons. Results provide insight into CSMN development.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 cell type, 4 development stage sets

Platform:

GPL339

Series:

GSE2039

19 Samples

Download data: CEL, EXP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL339 GPL1261

38 Samples

Download data: CEL, EXP

(Submitter supplied) 3 subtypes of cortical projection neurons were purified by fluorescence-activated cell sorting at 4 different stages of development from mouse cortex. A detailed description of the data set is described in Arlotta, P et al (2005). Keywords = corticospinal motor neuron callosal corticotectal cortex development FACS

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1076

Platform:

GPL339

19 Samples

Download data: CEL, EXP

(Submitter supplied) Developmental differences in gene expression in the postnatal mouse cochlear nucleus was analyzed at two or three ages using two different array platforms, the Affymetrix Mouse 430A GeneChip or the NIA 15K mouse cDNA microarray. These ages, P7, P14, and P21 parallel a critical period of neuron survival dependent on input from the auditory nerve. Keywords: parallel sample

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2144

Platforms:

GPL339 GPL236

18 Samples

Download data: CEL

Analysis of cochlear nucleus (CN) at postnatal days 7 (P7), 14, and 21. Deprivation of auditory nerve input from P7 to P14 results in neuron death in the anteroventral CN. Results provide insight into the molecular basis underlying this critical period of susceptibility to loss of afferent input.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL339

Series:

GSE2390

8 Samples

Download data: CEL

(Submitter supplied) subcerebral and callosal projection neurons were purified by retrograde labeling and FACS, total microRNA was isolated, and expression analysed via TaqMan qPCR expression profiling three independent samples each of subcerebral and callosal projection neurons were analysed

Organism:

Rattus norvegicus; Mus musculus

Type:

Other

Platform:

GPL25231

6 Samples

Download data: XLS

(Submitter supplied) To elucidate the pathways involved in the SCA7 retinal degeneration, we used DNA GeneChips and compared the gene expression profiles of the mutant mice (R7E) and the control ones (R7N). We performed these experiments at the onset stage of the disease (3w) as well as on the moderate one (9w) in order to correlate the transcriptional deregulations with the phenotype progression. We also compared the R6/2 mice vs wild type (wt) ones to identify between the deregulated transcripts the ones that were also differentially expressed in the R7E vs R7N mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2464

Platform:

GPL339

30 Samples

Download data

Analysis of retinas from R7E animals expressing the mutant ataxin-7, which harbors 90 glutamines. Polyglutamine expansion in ataxin-7 causes spinocerebellar ataxia type 7 (SCA7). Results provide insight into the molecular and cellular pathways involved in polyglutamine-induced retinal degeneration.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 4 cell type sets

Platform:

GPL339

Series:

GSE3634

30 Samples

Download data

(Submitter supplied) Corticospinal motor neurons (CSMN) are one specialized class of cortical excitatory neurons, which connect layer Vb of the cortex to the spinal cord. a master transcription factor –Forebrain expressed zinc finger 2 (Fezf2) – has been identified that is necessary for the fate specification of CSMN. Fezf2 alone can cell-autonomously instruct the acquisition of CSMN-specific features when expressed in diverse, permissive cellular contexts, in vivo. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5297

Platform:

GPL1261

14 Samples

Download data: CEL

(Submitter supplied) The neocortex contains an unparalleled diversity of neuronal subtypes responsible for complex behavior. Each cortical neuron has distinct traits, which are developmentally acquired under the control of batteries of neuron subtype-specific and pan-neuronal genes. The cis-regulatory logic that orchestrates the coordinated regulation of each unique combination of genes is not known for any class of neurons of the neocortex. more...

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL9250 GPL13112

6 Samples

Download data: BED, BW, TXT

Analysis of cortical neural progenitor cells overexpressing forebrain expressed zinc finger 2 (Fezf2) for 24 and 48 hours. Fezf2 expression vectors delivered to cells in utero. Results provide insight into the role of Fezf2 in the differentiation of corticospinal motor neurons from progenitors.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol, 2 time sets

Platform:

GPL1261

Series:

GSE56451

14 Samples

Download data: CEL

(Submitter supplied) Molecular mechanisms over differentiation and differential axonal targeting of distinct neuron subtypes in the cerebral cortex are beginning to be elucidated. These studies have focused on controls that specifically distinguish one subtype of neocortical projection neurons, e.g. corticospinal motor neurons (CSMN), from closely related corticothalamic projection neurons (CThPN) or intracortical callosal projection neurons (CPN). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

14 Samples

Download data: CEL

(Submitter supplied) The transcriptional repressor Zbtb20 is essential for specification of hippocampal CA1 pyramidal neurons. Moreover, ectopic expression of Zbtb20 is sufficient to transform subicular and retrosplenial areas of D6/Zbtb20S mice to CA1. We used microarrays to identify genes that are repressed by Zbtb20 in developing CA1 pyramidal neurons in the CA1-transformed cortex of D6/Zbtb20S mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

6 Samples

Download data: CEL

(Submitter supplied) Neuronal development requires a complex choreography of transcriptional decisions to obtain specific cellular identities. Realizing the ultimate goal of identifying genome-wide signatures that define and drive specific neuronal fates has been hampered by enormous complexity in both time and space during development. Here, we have paired high-throughput purification of pyramidal neuron subclasses with deep profiling of spatiotemporal transcriptional dynamics during corticogenesis to resolve lineage choice decisions. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

24 Samples

Download data: TXT

(Submitter supplied) Purpose:To assess changes in gene expression profiles of single cell from the wild type littermate controls cortices in E13.5, E15.5 and P0, and conditional knockout Bcl11a (and Bcl11b) at cortical projection neurons in the mouse cortices of the same ages. Methods: E13.5, E15.5 and P0 control and mutant cortices were carefully dissected under a clean environment. Then total RNA was isolated using an RNeasy Mini Kit (QIAGEN) according to the manufacturer’s protocol, quantified using NanoDrop ND-2000, and checked for RNA integrity using Agilent 2100 bioanalyzer. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21273

27 Samples

Download data: TXT

(Submitter supplied) Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC) alongside several intermediate forms. The AMC are characterized by being proliferative, phagocytic and migratory whereas the RMC are quiescent and exhibit a slow turnover rate. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

6 Samples

Download data: CEL, TXT

(Submitter supplied) Here we compare the gene expression profiles of two distict, fluorescently identified neuronal populations, the motor neruons (MN) and the decending commissural interneurons (dCIN) of the neonatal rat spinal cord isolated with laser microdissection. These two populations participate in the neuronal networks in the spinal cord where they have destinct functions in shaping (dCINs) and transferring the output to the muscles (MNs) during locomotion. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL88

22 Samples

Download data: CEL

(Submitter supplied) Molecular mechanisms controlling specification and differentiation of distinct neuron subtypes in the cerebral cortex are not well understood. Corticothalamic projection neurons (CThPN) are a diverse set of neurons, critical for function of the neocortex, but little is known about the molecular mechansims controlling their development. We used microarrays to detail CThPN gene expression at 3 developmental time points. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

6 Samples

Download data: CEL

(Submitter supplied) 3 subtypes of cortical projection neurons were purified by fluorescence-activated cell sorting (FACS) at 4 different stages of development from mouse cortex. A detailed description of the data set is described in Arlotta, P et al (2005) and Molyneaux, BJ et al (2009). The hybridization cocktails used here were originally applied to the Affymetrix mouse 430A arrays and submitted as GEO accession number GSE2039. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

19 Samples

Download data: CEL