GEO DataSets

(Submitter supplied) Transcriptome analysis of deletion mutant which coding HAT and APSES TF compared to wild type by NGS

Organism:

Aspergillus fumigatus Af293

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30552

15 Samples

Download data: TXT

(Submitter supplied) Gene expression profiling of Aspergillus fumigatus comparing controls grown at normal zinc concentration of aspergillus minimum media (77uM), low (1uM) and high (500uM) zinc concentrations.

Organism:

Aspergillus fumigatus Af293

Type:

Expression profiling by array

Platform:

GPL27053

3 Samples

Download data: GPR

(Submitter supplied) Determine the transcriptomic response of Aspergillus fumigatus strains to different alleles of atrR

Organism:

Aspergillus fumigatus Af293

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25907

8 Samples

Download data: TXT, WIG

(Submitter supplied) To determine the genomic binding sites for the Aspergillus fumigatus transcription factor AtrR, we utilized three different strains. One was the wild-type AfS35 which contains a wild-type copy of atrR but lacks any HA tag. The other two are both derived from AfS35 but contain a 3X HA tag replacing the stop codon of atrR. These strains are SPF89 and SPF112, respectively. SPF89 uses the wild-type atrR promoter to drive expression of the epitope-tagged allele while SPF112 uses the much strong hspA promoter to drive production of the same protein.

Organism:

Aspergillus fumigatus Af293

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL25869

6 Samples

Download data: WIG

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Aspergillus fumigatus Af293

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL25869 GPL25907

14 Samples

Download data: TXT, WIG

(Submitter supplied) RGS protein encoding genes gprK and rgsC deletion mutant microarray To identify the function of RGSs of A. fumigatus

Organism:

Aspergillus fumigatus Af293

Type:

Expression profiling by array

Platform:

GPL21999

6 Samples

Download data: GPR

(Submitter supplied) The functional coupling of calcium-mediated signalling and alkaline tolerance has been demonstrated in multiple fungi. The applied relevance of such interplay extends most notably to fungal pathogens of man where the physiological pH of serum and tissues exerts considerable alkaline stress. Drugs targeting the calcium-dependent phosphatase, calcineurin, are potent antifungal agents but also perturb human calcineurin signalling, it has therefore been postulated that abrogation of fungal alkaline tolerance could offer a valuable therapeutic adjunct. more...

Organism:

Aspergillus fumigatus; Aspergillus fumigatus Af293

Type:

Expression profiling by array

Platform:

GPL10341

10 Samples

Download data: MEV, TIFF

(Submitter supplied) In lung diseases caused by the major mould pathogen Aspergillus fumigatus the pulmonary epithelium is destroyed by invasive growth of fungal hyphae, a process thought to require fungal proteases. Here we show that the A. fumigatus pH-responsive transcription factor PacC governs expression of secreted proteases during invasive lung infections and is required for epithelial invasion and pathogenicity. more...

Organism:

Aspergillus fumigatus Af293; Aspergillus fumigatus

Type:

Expression profiling by array

Platform:

GPL10341

12 Samples

Download data: MEV

(Submitter supplied) Corticosteroid use has epidemiologically been associated with invasive aspergillosis. We found that hydrocortisone and MP in physiological concentrations cause a change in morphology of A. fumigatus 293 growth with a less dense core, and straighter outgrowth of longer hyphae. Treated with MP, we found a differential expression of genes annotated to cell wall structure, and to cell cycle programme compared to untreated control, which could explain the changes in morphology. more...

Organism:

Aspergillus fumigatus Af293

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17108

6 Samples

Download data: TXT

(Submitter supplied) Aspergillus fumigatus mutant strains were collected from bronchoalveolar lavage fluids (BALFs) during acute mouse infection (4 and 12 hours).

Organism:

Aspergillus fumigatus; Aspergillus fumigatus Af293

Type:

Expression profiling by array

Platform:

GPL10341

6 Samples

Download data: TXT

(Submitter supplied) In patients with chronic pulmonary disease colonization with the mold Aspergillus fumigatus is associated with declining pulmonary function and obstructive airway disease. One potential effector of this inflammatory response is the pulmonary mast cell. In vitro studies have demonstrated that A. fumigatus contact induces IgE-independent mast cell degranulation. Conversely, the Aspergillus secondary metabolite gliotoxin has been shown to suppress mast cell activation. more...

Organism:

Aspergillus fumigatus; Aspergillus fumigatus Af293

Type:

Expression profiling by array

Platform:

GPL10341

6 Samples

Download data: MEV

(Submitter supplied) Aspergillus fumigatus is the most common opportunistic mold pathogen of humans, causing invasive diseases in immunocompromised patients. In these patients, the fungus can invade the lungs and other organs, causing severe damage. Penetration of the pulmonary epithelium is a key step in the infectious process. A. fumigatus produces extracellular proteases to degrade the structural barriers of the host. more...

Organism:

Aspergillus fumigatus Af293; Aspergillus fumigatus

Type:

Expression profiling by array

Platform:

GPL14792

3 Samples

Download data: MEV, TXT

(Submitter supplied) Transcriptome of A. fumigatus shifted from ammoniumtartrate to different nitrogen sources and incubated for a defined time was compared. After 16h preculture, the fungus was transferred into fresh medium containing ammonium tartrate, sodium nitrate, proline or bsa as nitrogen source. After 1h, fungus was reisolated, RNA was prepared from fungus, transcriptome was assessed and used for further analysis.

Organism:

Aspergillus fumigatus; Aspergillus fumigatus Af293

Type:

Expression profiling by array

Platform:

GPL13789

8 Samples

Download data: TXT

(Submitter supplied) Deletion of AcuM caused attenuated virulence in mouse models of Aspergillosis, we carried out the microarry to figure out pathways have been changed to affect the virulence.

Organism:

Aspergillus fumigatus; Aspergillus fumigatus Af293

Type:

Expression profiling by array

Platform:

GPL10341

12 Samples

Download data: TXT

(Submitter supplied) Dendritic cells (DC) play an important role in host immunity by acting as a bridge between the innate and adaptive immune systems. They are antigen presenting cells that obtain microbial antigens by direct phagocytosis of the microbe or by cross presentation of antigens taken up from the surrounding environment. Monocyte derived DC were co-cultured with resting conidia of Aspergillus fumigatus at an MOI of 5 for 12 hours, cells were sampled every three hours. more...

Organism:

Aspergillus fumigatus; Aspergillus fumigatus Af293

Type:

Expression profiling by array

Platform:

GPL10341

10 Samples

Download data: MEV

(Submitter supplied) Iron is an essential cofactor for a wide range of cellular processes. Previous studies have shown that siderophore-mediated uptake and intracellular handling of iron are crucial for virulence of Aspergillus fumigatus. Here we show that the bzip-type transcription factor HapX plays a crucial role in the transcriptional remodeling required for adaption to iron starvation in this opportunistic fungal pathogen. more...

Organism:

Aspergillus fumigatus; Aspergillus fumigatus Af293

Type:

Expression profiling by array

Platform:

GPL10341

8 Samples

Download data: MEV

(Submitter supplied) Investigation of whole genome gene expression level changes in trichostatin A (TSA)-treated A. fumigatus Af293 compared to non-treated A. fumigatus Af293.

Organism:

Aspergillus fumigatus Af293

Type:

Expression profiling by array

Platform:

GPL9829

4 Samples

Download data: PAIR

(Submitter supplied) ss-DNA is synthesized in situ on glass substrates functionalized with amines. The synthesis process is proprietary but uses digital micromirror mediated photolithography to generate sufficient acid locally to remove acid labile protecting groups on 5'-terminal phosphoramidite monomers where the next phosphoramidite base will be coupled. The arrays can be used to hybridize cRNA or cDNA

Organism:

Aspergillus fumigatus Af293

1 Series

3 Samples

Download data