GSM589296[Accession] - GEO DataSets

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Items: 3

Select item 2000238951.

Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents

(Submitter supplied) Protein and mRNA levels for several selenoproteins, such as glutathione peroxidase-1 (Gpx1), are down-regulated dramatically by selenium (Se) deficiency. Selenoprotein levels in rats increase sigmoidally with increasing dietary Se and reach defined plateaus at the Se requirement, making them sensitive biomarkers for Se deficiency, but not high for Se status. Biomarkers for high Se status are needed as super-nutritional Se intakes are associated with beneficial and adverse health outcomes, but conventional biomarkers are not especially useful above the Se requirement. more...

Organism:: Mus musculus; Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL1261 GPL1355
36 Samples

Download data: CEL

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Accession:: GSE23895

ID:: 200023895

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000013552.

[Rat230_2] Affymetrix Rat Genome 230 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Rat Genome 230 2.0 Array is a powerful tool for toxicology, neurobiology, and other applications using rat as a model organism. more...