(Submitter supplied) Background: DNA methylation, a component of the epigenome that regulates both single genes and large sections of chromatin, is altered with ageing and is speculated to be one of the molecular mechanisms contributing to the ageing process. In our analysis, we sought to identify ageing-associated methylation changes at single- CpG-site resolution in blood leukocytes and to ensure that the observed changes were not due to differences in the proportions of leukocytes.
more...- Organism:
- Homo sapiens
- Type:
- Methylation profiling by genome tiling array
- Platform:
- GPL13534
- 143 Samples
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