GSM1126520[Accession] - GEO DataSets

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Items: 4

Select item 2000462201.

Inactive or moderately active human promoters are enriched for inter-individual epialleles

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL13534 GPL10999
24 Samples

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Series

Accession:: GSE46220

ID:: 200046220

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000462172.

Inactive or moderately active human promoters are enriched for inter-individual epialleles [Seq]

(Submitter supplied) We first demonstrate that non-genetically determined inter-individual differentially methylated regions (iiDMRs) can be temporally stable for at least two years. Then, we show that iiDMRS are associated with concomitant changes in chromatin state as measured by inter-individual differences in the levels of the histone variant H2A.Z. However, the correlation of promoter iiDMRs with gene expression is negligible and this correlation is not improved even by integrating H2A.Z information. more...