GSM1025302[Accession] - GEO DataSets

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Items: 3

Select item 2000418331.

Expression profiles of primary bone marrow derived mouse macrophages – untreated and treated with LPS or LPS+PGE

(Submitter supplied) The polarization of macrophages into an anti-inflammatory or regulatory phenotype plays an important role in resolving inflammation. PGE2 regulates macrophage polarization via a PKA dependent pathway. PKA phosphorylates SIKs, inhibiting their ability to phosphorylate CRTC3 in cells. This in turn allows CRTC3 to translocate to the nucleus where it acts as a co-activator with the transcription factor CREB to induce IL-10 transcription. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11533
11 Samples

Download data: CEL

Series

Accession:: GSE41833

ID:: 200041833

Analyze with GEO2R

Select item 1000115332.

[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html MoGene-1_1-st-v1.na31.mm9.transcript.csv #%create_date=Fri Aug 27 17:50:02 2010 PDT #%chip_type=MoGene-1_1-st-v1 #%lib_set_name=MoGene-1_1-st #%lib_set_version=v1 #%genome-species=Mus musculus #%genome-version=mm9 #%genome-version-ucsc=mm9 #%genome-version-ncbi=37 #%genome-version-create_date=2007-07-00 #%genome-lifted-method=liftOver #%genome-lifted_from-species=Mus musculus #%genome-lifted_from-version-ucsc=mm8 #%genome-lifted_from-version-ncbi=36 #%netaffx-annotation-date=2010-07-15 #%netaffx-annotation-netaffx-build=31 Protocol: see manufacturer's web site