U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 29

1.

Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome [methylation]

(Submitter supplied) Global patterns of DNA methylation, mediated by the DNA methyltransferases (DNMTs), are disrupted in all cancers by mechanisms that remain largely unknown, hampering their development as therapeutic targets. Combinatorial acute depletion of all DNMTs in a pluripotent human tumor cell line, followed by epigenome and transcriptome analysis, revealed DNMT functions in unprecedented detail. DNMT3B occupancy regulates methylation during differentiation, while an unexpected interplay was discovered in which DNMT1 and DNMT3B antithetically regulate methylation and hydroxymethylation in gene bodies, a finding confirmed in other cell types. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
27 Samples
Download data: TXT
Series
Accession:
GSE54840
ID:
200054840

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

(Submitter supplied) 1 difference between HumanMethylation450_15017482_v.1.1.bpm and HumanMethylation450_15017482_v.1.2.bpm: 1.1: 41636384,NEGATIVE,-99,Negative 604 1.2: 41636384,RESTORATION,Green,Restore Protocol: See manufacturer's website
Organism:
Homo sapiens
1671 Series
1 Related Platform
117793 Samples
Download data: BPM, CSV, TXT, XLSX
Platform
Accession:
GPL13534
ID:
100013534

3.

NCCIT_siRNA_3B+3L (biological replicate 3)

Organism:
Homo sapiens
Source name:
DNA from NCCIT human cells depleted of DNMT3B and DNMT3L by siRNA
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1527537
ID:
301527537

4.

NCCIT_siRNA_3B+3L (biological replicate 2)

Organism:
Homo sapiens
Source name:
DNA from NCCIT human cells depleted of DNMT3B and DNMT3L by siRNA
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1527536
ID:
301527536

5.

NCCIT_siRNA_DNMT3B (biological replicate 3)

Organism:
Homo sapiens
Source name:
DNA from NCCIT human cells depleted of DNMT3B by siRNA
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1527535
ID:
301527535

6.

NCCIT_siRNA_DNMT3B (biological replicate 2)

Organism:
Homo sapiens
Source name:
DNA from NCCIT human cells depleted of DNMT3B by siRNA
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1527534
ID:
301527534

7.

NCCIT_siRNA_DNMT1 (biological replicate 3)

Organism:
Homo sapiens
Source name:
DNA from NCCIT human cells depleted of DNMT1 by siRNA
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1527533
ID:
301527533

8.

NCCIT_siRNA_DNMT1 (biological replicate 2)

Organism:
Homo sapiens
Source name:
DNA from NCCIT human cells depleted of DNMT1 by siRNA
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1527532
ID:
301527532

9.

NCCIT_siRNA_NTC (biological replicate 2)

Organism:
Homo sapiens
Source name:
DNA from NCCIT human cells treated with a control non-targeting siRNA
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1527531
ID:
301527531

10.

NCCIT_RA_Differentiated

Organism:
Homo sapiens
Source name:
DNA from NCCIT retinoic acid induced differentiated human cells
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1325008
ID:
301325008

11.

NCCIT_Undifferentiated

Organism:
Homo sapiens
Source name:
DNA from NCCIT undifferentiated human cells
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1325007
ID:
301325007

12.

HCT116_DNMT1/DNMT3B_overexpression

Organism:
Homo sapiens
Source name:
DNA from HCT116 DNMT1/DNMT3B overexpression human colorectal carcinoma cells
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1325006
ID:
301325006

13.

HCT116_DNMT1_overexpression

Organism:
Homo sapiens
Source name:
DNA from HCT116 DNMT1 overexpression human colorectal carcinoma cells
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1325005
ID:
301325005

14.

HCT116_DNMT1/DNMT3B_KO

Organism:
Homo sapiens
Source name:
DNA from HCT116 DNMT1/DNMT3B genetic knockout human colorectal carcinoma cells
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1325004
ID:
301325004

15.

HCT116_DNMT3B_KO

Organism:
Homo sapiens
Source name:
DNA from HCT116 DNMT3B genetic knockout human colorectal carcinoma cells
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1325003
ID:
301325003

16.

HCT116_DNMT1_KO

Organism:
Homo sapiens
Source name:
DNA from HCT116 DNMT1 genetic knockout human colorectal carcinoma cells
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1325002
ID:
301325002

17.

HCT116_WT

Organism:
Homo sapiens
Source name:
DNA from HCT116 parental human colorectal carcinoma cells
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1325001
ID:
301325001

18.

NCCIT_siRNA_3A+3B+3L

Organism:
Homo sapiens
Source name:
DNA from NCCIT human cells depleted of DNTM3A, DNMT3B, and DNMT3L by siRNA
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1325000
ID:
301325000

19.

NCCIT_siRNA_3B+3L (biological replicate 1)

Organism:
Homo sapiens
Source name:
DNA from NCCIT human cells depleted of DNMT3B and DNMT3L by siRNA
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1324999
ID:
301324999

20.

NCCIT_siRNA_3A+3L

Organism:
Homo sapiens
Source name:
DNA from NCCIT human cells depleted of DNMT3A and DNMT3L by siRNA
Platform:
GPL13534
Series:
GSE54840 GSE54843
Download data
Sample
Accession:
GSM1324998
ID:
301324998

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Filters: Manage Filters

db=gds|term=GSE54840[Accession]|query=3|qty=2|blobid=MCID_6656a0b6e795547e5fd7938a|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Important Links

Recent activity

Clear Turn Off Turn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
You are here: NCBI > Genes & Expression > Gene Expression Omnibus (GEO) Datasets
Support Center