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Items: 1 to 20 of 48

1.

Methylation profiling data from medulloblastoma tumor samples

(Submitter supplied) Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large cohort of SHH-MBs across all age groups by sequencing, DNA methylation and expression profiling. Our data show that most adults but only half of the pediatric patients with SHH-MB will respond to SMO inhibition as predicted by molecular analysis of the primary tumor and tested in the SHH-xenografts, demonstrating that the next generation of SMO-inhibitor trials should be based on these predictive biomarkers. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
46 Samples
Download data: TXT
Series
Accession:
GSE49377
ID:
200049377

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

(Submitter supplied) 1 difference between HumanMethylation450_15017482_v.1.1.bpm and HumanMethylation450_15017482_v.1.2.bpm: 1.1: 41636384,NEGATIVE,-99,Negative 604 1.2: 41636384,RESTORATION,Green,Restore Protocol: See manufacturer's website
Organism:
Homo sapiens
1671 Series
1 Related Platform
117793 Samples
Download data: BPM, CSV, TXT, XLSX
Platform
Accession:
GPL13534
ID:
100013534

3.

MDT-MB-1234

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198448
ID:
301198448

4.

MDT-MB-755

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198446
ID:
301198446

5.

MDT-MB-452

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198445
ID:
301198445

6.

MDT-MB-1326

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198442
ID:
301198442

7.

MDT-MB-1201

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198441
ID:
301198441

8.

MDT-MB-107

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198440
ID:
301198440

9.

MDT-MB-1330

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198439
ID:
301198439

10.

MDT-MB-1200

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198438
ID:
301198438

11.

MDT-MB-516

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198437
ID:
301198437

12.

MDT-MB-707

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198436
ID:
301198436

13.

MDT-MB-826

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198435
ID:
301198435

14.

MDT-MB-194

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198434
ID:
301198434

15.

MDT-MB-1329

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198433
ID:
301198433

16.

MDT-MB-1250

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198432
ID:
301198432

17.

MDT-MB-1204

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198431
ID:
301198431

18.

MDT-MB-1202

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198430
ID:
301198430

19.

MDT-MB-1325

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198429
ID:
301198429

20.

MDT-MB-201

Organism:
Homo sapiens
Source name:
Primary medulloblastoma tumor tissue
Platform:
GPL13534
Series:
GSE49377
Download data
Sample
Accession:
GSM1198428
ID:
301198428

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