GEO DataSets

(Submitter supplied) We used DNA microarrays to identify discriminative gene signatures for the purpose of classifying n-3 PUFA-fed, carcinogen injected Sprague Dawley rats at the initiation and progression stages. Animals were assigned to three dietary treatments differeing only in the type of fat (corn oi/n-6 PUFA, fish oil/n-3 PUFA, or olive oli/n-9 monounsaturated fatty acid). The effects of diet on colonic mucosal gene expression signatures during tumor initiation with the progression of colon cancer. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL2890

43 Samples

Download data: TXT

(Submitter supplied) Media conditioned by undifferentiated human embryonic stem cells enhanced karyokinesis, cytokinesis and cell proliferation in cultures of differentiated, beating primary rat cardiomyocytes without altering their final contractile phenotype. Transcriptome analysis of proliferating cardiomyocytes revealed comprehensive activation of the ROCK 1 and 2 G-protein coupled receptor (GPCR) pathway associated with cytokinesis, and the RAS/RAF/MEK/ERK receptor tyrosine kinase pathways (RTK) and JAK/STAT-cytokine pathway involved in cell cycle progression. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL2896 GPL2890

18 Samples

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(Submitter supplied) Pyrroloquinoline quinone (PQQ) is a naturally occurring compound and known to improve growth and reproductive performance when added to diets of PQQ-deprived rodents. To understand its mechanism of action, changes in hepatic gene expression were measured in rats fed diets with or without added PQQ. Of the ~10,000 genes and ESTs analyzed, 4.7% of the transcripts were sensitive to changes in PQQ dietary status. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL2890

25 Samples

Download data: CSV

(Submitter supplied) Time-course gene expression profiles were obtained from lung tissues of the rats treated with room air, intermittent- (IH) or sustained hypoxia (SH) for 1, 3, 7, 14 and 30 days using CodeLink microarrays. Using a systems biology approach, we observed that two different mechanisms are involved in the lung responses to IH and SH: IH leads to increased G-protein coupled signaling-, ion transport-, neuronal- and steroid hormone receptor activities; whereas SH causes increased blood vessel morphogenesis and immune responses. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3914

Platform:

GPL2890

42 Samples

Download data: TXT

Analysis of lungs from adult males subjected to intermittent (IH) or sustained hypoxia (SH) for up to 30 days. IH is associated with sleep-disordered breathing, and SH with parenchymal lung disorders. Results provide insight into molecular mechanisms underlying hypoxic lung response during IH or SH.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 stress, 6 time sets

Platform:

GPL2890

Series:

GSE8705

42 Samples

Download data: TXT

(Submitter supplied) Goal of the experiment: To examine the effects of estrogen and testosterone on gene expression in the rat mesenteric arteries. Brief description of the experiment: A dramatic difference exists in the timing of development of cardiovascular disease in men vs. women. The primary candidates underlying the cause of gender differences in cardiovascular disease are the sex steroids, estrogen and testosterone. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL2890

24 Samples

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(Submitter supplied) CodeLink UniSet Rat I is designed for expression monitoring of a broad range of rat genes derived from NCBI and clustered to generate consensus sequences. Identifying patterns of differential mRNA expression over a large set of genes is an excellent method to identify targets, characterize action mechanisms, and make initial predictions of global drug effects. Well-annotated mRNA or coding sequences were chosen from the entire UniGene set to ensure usefulness to a large range of researchers in basic research, biotechnology, and drug development applications. more...

Organism:

Rattus norvegicus

1 DataSet

5 Series

140 Samples

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