GPL22499[RGSE] - GEO DataSets

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Items: 3

Select item 2002052031.

Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL29970 GPL22499
90 Samples

Download data: CEL

Series

Accession:: GSE205203

ID:: 200205203

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002052022.

Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]

(Submitter supplied) The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify doses of APAP (300 and 1000 mg/kg in mice and rats, respectively) yielding similar hepatic burdens of NAPQI, to enable the comparison of temporal liver tissue responses under conditions of equivalent chemical insult.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL22499
45 Samples

Download data: CEL, XLS

Series

Accession:: GSE205202

ID:: 200205202

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000874393.

The effect of Schisandra chinensis fruit extract (SCE) and Schisandrin B (SchB) on gene expression profile in TGF-β1-treated A7r5 rat aortic smooth muscle cell

(Submitter supplied) Schisandra chinensis fruit extract (SCE) and its active ingredient Schisandrin B (SchB), which are effective in the treatment of vascular diseases, have been known to suppress transforming growth factor β1 (TGF-β1)-mediated Smad activation and myosin light chain (MLC) phosphorylation in vascular smooth muscle cells (VSMCs). However, it is still largely unknown about the pharmacologic effects and mechanisms of SCE and SchB on TGF-β1-induced intracellular signaling pathways in vascular smooth muscle cells (VSMCs). more...