GEO DataSets

(Submitter supplied) The transcription factor IRF4 is well known to be quickly upregulated after TCR activation, and magnitude of IRF4 expression is proportional to the strength of TCR activation. However, contradictory reports have been published as to the role of IRF4 in mouse T-cells during acute and chronic viral infections. Furthermore, no data have been published as to the role of IRF4 in human CD8 T-cells, both in normal and pathological conditions. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

40 Samples

Download data: CSV

(Submitter supplied) To investigate the effect of VDR in the regulation of K562 cells. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different cells.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

6 Samples

Download data: XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Other

Platforms:

GPL16791 GPL24676

12 Samples

Download data: BIGWIG, BW

(Submitter supplied) Combination analysis of m6A-seq, IGF2BP1-KD RNA-seq, IGF2BP1 CLIP-seq in H929 cells

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

15 Samples

Download data

(Submitter supplied) Exudates of non-healing wounds contain drivers of pathogenicity. We utilized >800 exudates from non-healing and healing wounds of diverse etiologies, collected by three different methods, to develop a wound-specific, cell-based functional biomarker assay. Human dermal fibroblast proliferation served as readout to a) to differentiate between healing and non-healing wounds, b) follow the healing process of individual patients, and c) assess the effects of therapeutics for chronic wounds ex vivo. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

9 Samples

Download data: TXT

(Submitter supplied) Exudates of non-healing wounds contain drivers of pathogenicity. We utilized >800 exudates from non-healing and healing wounds of diverse etiologies, collected by three different methods, to develop a wound-specific, cell-based functional biomarker assay. Human dermal fibroblast proliferation served as readout to a) to differentiate between healing and non-healing wounds, b) follow the healing process of individual patients, and c) assess the effects of therapeutics for chronic wounds ex vivo. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

6 Samples

Download data: TXT

(Submitter supplied) Non-Small Cell Lung Cancer (NSCLC) is a highly lethal respiratory tumor with unclear molecular mechanisms. RNA-seq data from 34 early-stage samples and adjacent non-cancerous tissues identified 1088 differentially expressed genes using Deseq2. Mendelian randomization (MR) analysis of 26,153 genes and 63,053 LUSC patients, including 7,838,805 SNPs, identified 213 potential exposure factors. Five differentially expressed genes (GYPE, PODXL2, RNF182, SIRPG, WNT7A) were identified, with PODXL2 as a risk factor. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

67 Samples

Download data: TXT

(Submitter supplied) Master hematopoietic transcription factors and long non-coding RNAs (lncRNAs) coordinate shaping lineage-restricted gene expression programs during hematopoietic differentiation. The architectural protein CCCTC-binding factor (CTCF) has emerged as an important regulator of gene expression in cell differentiation. However, the relationship and its regulatory effect on lncRNA genes in hematopoiesis remains elusive. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

9 Samples

Download data: BIGWIG

(Submitter supplied) Master hematopoietic transcription factors and long non-coding RNAs (lncRNAs) coordinate shaping lineage-restricted gene expression programs during hematopoietic differentiation. The architectural protein CCCTC-binding factor (CTCF) has emerged as an important regulator of gene expression in cell differentiation. However, the relationship and its regulatory effect on lncRNA genes in hematopoiesis remains elusive. more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL16791

6 Samples

Download data: BIGWIG

(Submitter supplied) Master hematopoietic transcription factors and long non-coding RNAs (lncRNAs) coordinate shaping lineage-restricted gene expression programs during hematopoietic differentiation. The architectural protein CCCTC-binding factor (CTCF) has emerged as an important regulator of gene expression in cell differentiation. However, the relationship and its regulatory effect on lncRNA genes in hematopoiesis remains elusive. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL16791

16 Samples

Download data: BIGWIG

(Submitter supplied) TAF2 is the second largest subunit of general transcription factor TFIID. Although TFIID complex is putatively considered as a general initiation factor, gene-specific functions have been reported for several TAF subunits within it. To gain insights for TAF2 function in transcriptional regulation, genomic occupancy of TAF2 and transcriptiome of cells depleted of TAF2 are examined.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL16791 GPL18573

17 Samples

Download data: BIGWIG

(Submitter supplied) A total of 9 patients diagnosed with HR+/HER2- breast cancer were recruited for this study. Tissue specimens were obtained by surgical excision without prior treatment. Tumor tissues were mechanically dissociated and enzymatically digested on the day of surgery. We profiled transcriptomic characteristics using single cell RNA-seq to investigate the relationship between migratory tumor subtypes and cancer-associated fibroblasts (CAFs) in tumor progression.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

9 Samples

Download data: MTX, TSV

(Submitter supplied) Amplification of the 8p11-p12 genomic region occurs in 30% of luminal B breast cancers and results in coordinate overexpression of several oncogenes, including ASH2L, which upregulates gene expression via promoter tri-methylation of lysine 4 on histone 3 (H3K4me3). Since 8p11-p12 amplification is associated with endocrine resistance, the major cause of breast cancer mortality, understanding the underlying biology is essential to improving treatment options for patients. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL16791

12 Samples

Download data: BROADPEAK

(Submitter supplied) Ferroptosis, an emerging nonapoptotic, regulated cell death process distinguished by iron accumulation and subsequent lipid peroxidation, is intricately implicated in the development and progression of multiple cancer types. Here, we aimed to reveal that triggering ferroptosis is a promising treatment strategy for ovarian cancer. In this study, we not only validated that daphnetin caused ferroptosis, but evaluated the effects of daphnetin (and/or cisplatin) in vitro and vivo.Here, we elucidated that daphnetin, a natural product isolated from Daphne Korean Nakai, can exert antitumor effects by inducing the death and suppressing the migration of ovarian cancer cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

18 Samples

Download data: XLS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL16791

72 Samples

Download data: BW, NARROWPEAK

(Submitter supplied) Distal regulatory elements, such as enhancers, play a pivotal role in dictating cell identity by controlling the transcriptional status of specific cells. The comprehensive understanding of the epigenetic landscape, encompassing enhancer establishment and chromatin accessibility, during the differentiation of human Th17 cells remains incomplete. Leveraging ATAC-seq based chromatin accessibility profile along with the profiling of key histone marks we identified potential enhancers crucial for fate specification of Th17 cells. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL16791

50 Samples

Download data: BW

(Submitter supplied) Distal regulatory elements, such as enhancers, play a pivotal role in dictating cell identity by controlling the transcriptional status of specific cells. The comprehensive understanding of the epigenetic landscape, encompassing enhancer establishment and chromatin accessibility, during the differentiation of human Th17 cells remains incomplete. Leveraging ATAC-seq based chromatin accessibility profile along with the profiling of key histone marks we identified potential enhancers crucial for fate specification of Th17 cells. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL16791

22 Samples

Download data: NARROWPEAK

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL24676 GPL16791

52 Samples

Download data

(Submitter supplied) Transcriptome wide-comparison between MTV-low and -high groups was performed with three types: 1) cancer to normal site ratio, cancer site, and normal site. Among three types of comparison, the cancer-to-normal site ratio was the most informative. 211 genes were generally upregulated, and 166 genes were downregulated in the MTV-high group compared to the MTV-low group. Of 211 upregulated gens, 44 showed more than a 2-fold difference and statistical significance. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

28 Samples

Download data: TXT