GEO DataSets

(Submitter supplied) Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from cryopreserved diagnostic bone marrow samples.

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL16131

172 Samples

Download data: CEL, CYCHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by SNP array

Platforms:

GPL16131 GPL23159

19 Samples

Download data: CEL, CHP, CYCHP

(Submitter supplied) In this study we present a thus far undescribed, reciprocal, unbalanced chromosomal translocation between the long arm of chromosome 21 and the short arm of chromosome X, t(X;21)(p11.4;q22.12), in five cases with Myelodysplastic Syndromes and Acute Myeloid Leukemias (MDS/AML). The translocation was isolated or accompanied by one additional change and is not generating a fusion gene. Deletion of RUNX1 at chromosome 21 and of BCOR at chromosome X was shown by Fluorescence In Situ Hybridization (FISH) and Single Nucleotide Polymorphism array (SNPa) analysis. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL16131

4 Samples

Download data: CEL, CYCHP

(Submitter supplied) Divergence of K-562 genomes through in vitro clonal evolution revealed by comparing three sublines. Comparison of three K-562 sublines

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL16131

3 Samples

Download data: CEL, CYCHP

(Submitter supplied) We evaluated 6 established ostesarcoma cell lines. Copy Number Variation and loss-of-heterozygosity status were explored to look for similar patterns across cell lines

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array; Genome variation profiling by SNP array

Platform:

GPL16131

6 Samples

Download data: CEL, CYCHP

(Submitter supplied) In precursor B-cell acute lymphoblastic leukemia (ALL), whole chromosome uniparental isodisomy (wUPD) occurs almost uniquely in the high hyperdiploid (51-67 chromosomes) (HH) subtype. Comparison of 26 HH with wUPD with 31 with noUPD, showed a higher modal number of chromosomes and gains of 5+ in wUPD. Mutations in genes within epigenetic pathways with upregulation of genes involved in cellular response to stress and stimuli, and mutations in RAS/RTK pathways and upregulation of genes in RNA Polymerase III pathway were seen in wUPD and noUPD respectively. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL16131

56 Samples

Download data: CEL, CYCHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platforms:

GPL16131 GPL21558

35 Samples

Download data: CEL, CYCHP, OSCHP

(Submitter supplied) T-cell lymphoblastic lymphoma T-LBL is a rare aggressive neoplasm of precursor T cells whose pathogenesis is not fully elucidated and it is closely related to acute lymphoblastic leukemia (T-ALL), the most common subtype of cancer in children, although recent studies suggest biological differences between the two entities.

Organism:

Homo sapiens

Type:

Genome variation profiling by array; Genome binding/occupancy profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL16131

23 Samples

Download data: CEL, CYCHP, XLSX

(Submitter supplied) The search for biomarkers to predict radiosensitivity is important not only to individualize radiotherapy of cancer patients but also to forecast radiation exposure risks. The aim of this study was to devise a machine learning method to stratify radiosensitivity and to investigate its association with copy number variations (CNVs) as markers of sensitivity to ionizing radiation. We used the Affymetrix CytoScan HD microarrays to for CNV estimation. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL16131

129 Samples

Download data: CEL, TXT

(Submitter supplied) Cytogenetics abnormalities (CA) are known to be the preponderant prognostic factor in multiple myeloma (MM). Our team has recently developeda prognostic score based on 6 CA, where del(1p32) appears to be the second worst abnormality after del(17p). The aim of this study was to confirm the adverse impact of 1p32 deletion on newly-diagnosed multiple myeloma (NDMM) patients. Among 2551 NDMM patients, 11% were harboring del(1p32). more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL16131

1395 Samples

Download data: CEL, CYCHP

(Submitter supplied) we used single-cell transcriptomics and genotyping arrays to characterize 17 neuroblastoma samples across different risk groups and genetic subsets.Fresh samples, obtained from surgical resections and core biopsies, were used for genome variation profiling. DNA extraction from neuroblastoma samples was performed using the DNeasy blood and tissue kit (Qiagen) according to the manufacturer’s protocol. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL16131

23 Samples

Download data: CEL

(Submitter supplied) Neuroblastomas are characterized by recurrent segmental and/or numerical chromosomal abberations such as MYCN-amplification or 11q-deletion. To further elucidate recurrent chromosomal alterations, 16 neuroblastoma cell lines were investigated.

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL16131

16 Samples

Download data: CEL, CYCHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Expression profiling by high throughput sequencing; Genome variation profiling by SNP array

Platforms:

GPL24676 GPL16131 GPL23159

108 Samples

Download data: CEL, CHP, CYCHP, TXT

(Submitter supplied) Chromothripsis is a mitotic catastrophe that arises from multiple double strand breaks and incorrect re-joining of one or a few chromosomes. We report on incidence, distribution, and features of chromothriptic events in T-cell acute lymphoblastic leukemias (T-ALL). Chromothripsis was detected in 11.6% of analyzed T-ALL and occurred only in adult cases with an immature phenotype (30%). It affected 1 to 4 chromosomes, and recurrently involved chromosomes 1, 6, 7, and 17. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL16131

15 Samples

Download data: CEL, CYCHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Capra hircus; Cavia porcellus; Ignicoccus hospitalis; Homo sapiens; Mus musculus

Type:

Genome variation profiling by genome tiling array

7 related Platforms

56 Samples

Download data: CEL, CYCHP, OSCHP

(Submitter supplied) Pediatric nodal marginal zone lymphoma (PNMZL) is an unusual and poorly understood primary B-cell nodal neoplasms. Patients are predominantly young males presenting with localized disease. The tumor shows overlapping morphological features with pediatric-type follicular lympgoma. The alterations involved in the pathogenesis of PNMZL are not known.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL16131

3 Samples

Download data: CEL, CYCHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Genome variation profiling by SNP array

Platforms:

GPL16131 GPL18573

40 Samples

Download data: CEL, CSV

(Submitter supplied) ​Cancer Gastric (CG) is a multifactorial disease with an important genetics background, per example copy number variants (CNV). Microarray data analysis were performed to identify CNV that could be contributing to those Mexican patient's clinical phenotypes

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL16131

34 Samples

Download data: CEL, CYCHP, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array; Genome variation profiling by SNP array; SNP genotyping by SNP array; Genome variation profiling by high throughput sequencing

Platforms:

GPL18573 GPL16131

3 Samples

Download data: CEL, CYCHP, VCF

(Submitter supplied) SNP array was combined with next generation sequencing (NGS) to identify a unique de novo germline mutation in CTCF that became homozygous in the tumor. SNP array shows an LOH through chr16q where CTCF is located.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array; Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL16131

1 Sample

Download data: CEL, CYCHP