GEO DataSets

(Submitter supplied) Macrophage responses to activation are fluid and dynamic in their ability to respond appropriately to challenges, a role integral to host defence. While bacteria can influence macrophage differentiation and polarization into pro-inflammatory and alternatively activated phenotypes through direct interactions, many questions surround indirect communication mechanisms mediated through secretomes derived from gut bacteria, such as lactobacilli. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

32 Samples

Download data: TXT

(Submitter supplied) Cryopreservation process deregulates the expression of pathways important for fertility in human spermatozoa Study design, size, duration (max. 75 words): Semen samples were obtained from 20 normospermic men from April to May 2022. Each sample was divided in two aliquots. From one aliquot total RNA was immediately extracted. The second aliquot was slowly cryopreserved and after a week of storage in liquid nitrogen total RNA was extracted. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

11 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of Oncopig and human bladder cancer cell lines comparing control untreated cells to cell treated with gemcitabine for 48 hours. Goal was to compare similar transcriptional alterations in response to gemcitabine treatment across both species

Organism:

Sus scrofa; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL10332 GPL18437

6 Samples

Download data: TXT

(Submitter supplied) Global mRNA expression profiling of patient derived colon cancer xenograft models (N=13) were collected using Agilent human whole genome array (G4845A AMADID 026652, cRNA 4x44k V2) . All xenograft models carried an activating. All Mice were either untreated (controls) or treated with treated with cetuximab (25 mg/kg, twice weekly, i.p., Merck) and trametinib (0.5 mg/kg, five subsequent days per week, p.o., Hycultec) to establish response characteristics. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

33 Samples

Download data: TXT

(Submitter supplied) To investigate the effect of DHMEQ on gene expression, we have employed whole genomic microarray expression profiling using HESC cells

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

4 Samples

Download data: TXT

(Submitter supplied) To investigate the relationship between the LEN resistance and gene expression profile, we generated LEN-resistant (LEN-R) cell clones using U266 and NCU-MM1 cell lines by chronically exposing low dose of LEN (0.1 to 10 μM). The parental and LEN-R MM cells were incubated with either DMSO or LEN (10 μM) for 24 h.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

8 Samples

Download data: TXT

(Submitter supplied) To investigate the effect of EGFR disruption on gene expression, we generated EGFR-knockout (EGFR-KO) cell clones using CRISPR/Cas9 system with OSCC cell lines HSC-2 and HSC-3 cells. The OSCC cells were incubated for 48 h in vitro.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

8 Samples

Download data: TXT

(Submitter supplied) Investigate genes expression profiles of postmenopausal osteoporosis in bone(femur)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

15 Samples

Download data: TXT

(Submitter supplied) Background: Validated markers to predict outcome in rectal cancer patients treated with multimodal therapy remain elusive. Identifying molecular profiles for disease prognosis would be required for the design of clinical trials aimed at optimizing risk-adapted therapies. We have therefore used whole genome expression profiling of tumors of a large cohort of patients enrolled in the multicenter trials of the German Rectal Cancer Study Group (GRCSG) to identify molecular profiles for individualized therapy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

245 Samples

Download data: TXT

(Submitter supplied) Determination of the ion channel and transporters gene expression profile of Bevacizumab-adapted colorectal adenocarcinoma cells HCT116

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

10 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of primary human malignant B cells from patients with chronic lymphocytic leukaemia (CLL), comparing untreated CLL cells with CLL cells that have been treated 24h with 200nM mithramycin. Mithramycin intercalates into GC-rich regions of DNA to inhibit binding of the transcription factor SP1. The goal of this experiment is to gain understanding of the genes regulated by SP1 in primary CLL cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

4 Samples

Download data: TXT

(Submitter supplied) Polybrominated diphenyl ethers (PBDEs) are persistent organic chemicals implied as flame re-tardants. Humans are mainly exposed to BDE-47, -99 and -209 congeners by diet. PBDEs are metabolic disruptors with liver as main target organ. To investigate their mode of action at a human relevant concentration, we exposed HepG2 cells to these congeners and their mixture at 1 nM for 72h, analyzing their transcriptomic and proteomic profiles. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

14 Samples

Download data: TXT

(Submitter supplied) The mechanism governing the transition of human embryonic stem cells towards differentiated cells is only partially understood. To explore this transition, the activity and expression of the ubiquitous phosphoinositide-3-kinase (PI3K α and β) were modulated. This study reports a pathway that dismantles the repression imposed by the EZH2 polycomb repressor on an essential stemness gene, NODAL, and on transcription factors required at differentiation to trigger primitive streak formation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

12 Samples

Download data: TXT

(Submitter supplied) The aim of this research was to confirm the regulatory effect of LASP1 on gene expression in the development of prostate cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

2 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

54 Samples

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(Submitter supplied) Question Addresses: What is the gene expression profile from human umbilical vein endothelial cells (HUVEC) and human Jurkat T cells after irradiation (IR)? What, if any, is the effect of co-culturing these two cell types on gene expression? There are eight experimental conditions for this experiment: (1) non-irradiated HUVEC; (2) irradiated HUVEC; (3) non-irradiated Jurkat; (4) irradiated Jurkat; (5) non-irradiated HUVEC + non-irradiated Jurkat+; (6) non-irradiated HUVEC + irradiated Jurkat; (7) irradiated HUVEC + non-irradiated Jurkat; (8) irradiated HUVEC + irradiated Jurkat. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

18 Samples

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(Submitter supplied) Question Addressed: What is the gene expression profile from human bone marrow endothelial cells (BMEC) and human CD34+ stem and progenitor cells (HSPC) after irradiation (IR)? What, if any, is the effect of co-culturing these two cell types on gene expression? There are eight experimental conditions for this experiment: (1) non-irradiated BMEC; (2) irradiated BMEC; (3) non-irradiated CD34+; (4) irradiated CD34+; (5) non-irradiated BMEC + non-irradiated CD34+; (6) non-irradiated BMEC + irradiated CD34; (7) irradiated BMEC + non-irradiated CD34+; (8) irradiated BMEC + irradiated CD34+. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

36 Samples

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(Submitter supplied) Transcriptional profiling of Peripheral Blood mononuclear cells (PBMCs) in apparently healthy postmenopausal women consuming flavanones in grapefruit juice (340 ml/day providing around 210 mg of naringenin glycosides) or flavanone-free placebo drink for 6 months in a cross-over design with a 2-month washout period between consumption of two studied drinks. Goal was to determine the effects of chronic consumption of flavanones in garpefruit juice on global gene expression profiles in humans

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

18 Samples

Download data: TXT

(Submitter supplied) To investigate the effect of apigenin on gene expression, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to suppress the cell proliferation of human acute myeloid leukemia (AML) cell lines. HL-60 amn NB4 cells were treated with apigenin for 24 h in vitro.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

4 Samples

Download data: TXT

(Submitter supplied) The transcriptomic heterogeneity of the prostate cancer was tested by profiling histologically distinct but equally graded (Gleason score 4+5=9/10) cancer nodules from a surgically removed prostate cancer. We found that not only that the genes were differently regulated in the two nodules but also that expression fluctuations were differently controlled and the gene networks differently remodeled.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

8 Samples

Download data: TXT