GEO DataSets

(Submitter supplied) Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell populations poised to becoming iPSCs by genome-wide analyses. We show that induced pluripotency elicits two transcriptional waves, which are driven by c-Myc/Klf4 (first wave) and Oct4/Sox2/Klf4 (second wave). Cells that become refractory to reprogramming activate the first but fail to initiate the second transcriptional wave and can be rescued by elevated expression of all four factors. more...

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL10283

5 Samples

Download data: PAIR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Methylation profiling by array; Methylation profiling by high throughput sequencing

Platforms:

GPL10283 GPL11002 GPL13112

29 Samples

Download data: BEDGRAPH, PAIR, WIG

(Submitter supplied) Maternal 5-HT1A-receptor (R) is required for the timely development of the hippocampus and the establishment of emotional behaviors in Swiss-Webster (SW) mice. A partial and/or complete loss of maternal 5-HT1AR results in delayed ventral dentate granule cell (v-DGC) development and subsequent anxiety-like phenotype in the wild-type offspring by a non-genetic, presumably epigenetic mechanism. Here we tested v-DGCs for genome-wide DNA methylation changes elicited by the receptor deficient maternal environment. more...

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL10283

21 Samples

Download data: PAIR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Rattus norvegicus; Human alphaherpesvirus 2; Merkel cell polyomavirus; Homo sapiens; Murid gammaherpesvirus 4; Betapolyomavirus hominis

Type:

Expression profiling by array; Non-coding RNA profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by genome tiling array

5 related Platforms

61 Samples

Download data: BIGWIG, CEL, PAIR, TXT

(Submitter supplied) Cancer cells have an altered distribution of DNA methylation and express aberrant DNA methyltransferase 3B transcripts, which encode truncated proteins. To test if a truncated DNMT3B isoform disrupts DNA methylation in vivo, we constructed transgenic mice expressing DNMT3B7, a common truncated DNMT3B isoform in cancer cells. DNMT3B7 transgenic mice exhibit altered embryonic development, including lymphopenia, craniofacial abnormalities, and cardiac defects, similar to Dnmt3b-deficient animals, but rarely develop cancer. more...

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL10283

6 Samples

Download data: PAIR

(Submitter supplied) Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here, we show that iPSCs obtained from fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns. Moreover, we demonstrate that cellular origin influences the in vitro differentiation potentials of iPSCs into embryoid bodies (EBs) and different hematopoietic cells. more...

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL10283

18 Samples

Download data: PAIR