"Clinical Genetics, Academic Medical Center"[submitter] AND "FLNC"[gen - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 1299957	NM_001458.5(FLNC):c.-26_-9dup	FLNC	Duplication (5 prime UTR variant)	FLNC-related disorder	GLikely benign
Select item 472191	NM_001458.5(FLNC):c.96G>A (p.Ala32=)	FLNC	Single nucleotide variant (synonymous variant)	Distal myopathy with posterior leg and anterior hand involvement +4 more	GLikely benign
Select item 129081	NM_001458.5(FLNC):c.147C>T (p.His49=)	FLNC	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +6 more	GBenign
Select item 472024	NM_001458.5(FLNC):c.294G>A (p.Glu98=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +5 more	GLikely benign
Select item 1284477	NM_001458.5(FLNC):c.558G>A (p.Gln186=)	FLNC	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +4 more	GLikely benign
Select item 382744	NM_001458.5(FLNC):c.561C>T (p.Asp187=)	FLNC	Single nucleotide variant (synonymous variant)	not specified +7 more	GBenign/Likely benign
Select item 195145	NM_001458.5(FLNC):c.597C>T (p.Ala199=)	FLNC	Single nucleotide variant (synonymous variant)	Dilated Cardiomyopathy, Dominant +8 more	GBenign/Likely benign
Select item 383827	NM_001458.5(FLNC):c.600C>T (p.Pro200=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +7 more	GBenign/Likely benign
Select item 1284592	NM_001458.5(FLNC):c.602-16T>A	FLNC	Single nucleotide variant (intron variant)	Myofibrillar myopathy 5 +3 more	GLikely benign
Select item 506352	NM_001458.5(FLNC):c.602-11C>T	FLNC	Single nucleotide variant (intron variant)	Dilated Cardiomyopathy, Dominant +4 more	GBenign
Select item 129096	NM_001458.5(FLNC):c.720T>C (p.Ile240=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +6 more	GBenign
Select item 129099	NM_001458.5(FLNC):c.795T>C (p.Gly265=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +6 more	GBenign
Select item 258154	NM_001458.5(FLNC):c.850+18G>A	FLNC	Single nucleotide variant (intron variant)	not specified +4 more	GBenign
Select item 258155	NM_001458.5(FLNC):c.969+14G>T	FLNC	Single nucleotide variant (intron variant)	not specified +4 more	GLikely benign
Select item 129078	NM_001458.5(FLNC):c.1032C>T (p.Val344=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +6 more	GBenign
Select item 659222	NM_001458.5(FLNC):c.1225G>A (p.Asp409Asn)	FLNC (D409N)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +5 more	GUncertain significance
Select item 129079	NM_001458.5(FLNC):c.1374C>T (p.Pro458=)	FLNC	Single nucleotide variant (synonymous variant)	Cardiomyopathy +7 more	GBenign
Select item 291068	NM_001458.5(FLNC):c.1425C>T (p.Asn475=)	FLNC	Single nucleotide variant (synonymous variant)	FLNC-related disorder +8 more	GBenign
Select item 390849	NM_001458.5(FLNC):c.1434C>T (p.Arg478=)	FLNC	Single nucleotide variant (synonymous variant)	Cardiomyopathy +6 more	GLikely benign
Select item 129080	NM_001458.5(FLNC):c.1458C>A (p.Pro486=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +6 more	GBenign
Select item 418215	NM_001458.5(FLNC):c.1519G>A (p.Gly507Arg)	FLNC (G507R)	Single nucleotide variant (missense variant)	not specified +7 more	GConflicting classifications of pathogenicity
Select item 258126	NM_001458.5(FLNC):c.1549+15C>A	FLNC	Single nucleotide variant (intron variant)	Dilated Cardiomyopathy, Dominant +5 more	GBenign
Select item 418216	NM_001458.5(FLNC):c.1568T>C (p.Val523Ala)	FLNC (V523A)	Single nucleotide variant (missense variant)	Distal myopathy with posterior leg and anterior hand involvement +7 more	GConflicting classifications of pathogenicity
Select item 193632	NM_001458.5(FLNC):c.1577G>A (p.Arg526Gln)	FLNC (R526Q)	Single nucleotide variant (missense variant)	not provided +6 more	GBenign/Likely benign
Select item 129082	NM_001458.5(FLNC):c.1614C>T (p.Tyr538=)	FLNC	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +5 more	GBenign
Select item 290512	NM_001458.5(FLNC):c.1813+11G>T	FLNC	Single nucleotide variant (intron variant)	not provided +5 more	GConflicting classifications of pathogenicity
Select item 194038	NM_001458.5(FLNC):c.1902G>A (p.Glu634=)	FLNC	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +7 more	GBenign/Likely benign
Select item 471990	NM_001458.5(FLNC):c.1923C>T (p.His641=)	FLNC	Single nucleotide variant (synonymous variant)	Distal myopathy with posterior leg and anterior hand involvement +7 more	GBenign/Likely benign
Select item 421215	NM_001458.5(FLNC):c.1948C>T (p.Arg650Ter)	FLNC (R650*)	Single nucleotide variant (nonsense)	Cardiovascular phenotype +5 more	GPathogenic
Select item 1284495	NM_001458.5(FLNC):c.2065G>A (p.Glu689Lys)	FLNC (E689K)	Single nucleotide variant (missense variant)	not provided +4 more	GUncertain significance
Select item 539419	NM_001458.5(FLNC):c.2068T>C (p.Phe690Leu)	FLNC (F690L)	Single nucleotide variant (missense variant)	Cardiomyopathy +6 more	GConflicting classifications of pathogenicity
Select item 258130	NM_001458.5(FLNC):c.2122-17T>C	LOC129999273, FLNC	Single nucleotide variant (intron variant)	Dilated Cardiomyopathy, Dominant +4 more	GBenign
Select item 258132	NM_001458.5(FLNC):c.2125G>A (p.Ala709Thr)	FLNC, LOC129999273 (A709T)	Single nucleotide variant (missense variant)	not specified +6 more	GBenign/Likely benign
Select item 472000	NM_001458.5(FLNC):c.2180G>A (p.Arg727His)	FLNC (R727H)	Single nucleotide variant (missense variant)	Distal myopathy with posterior leg and anterior hand involvement +6 more	GBenign/Likely benign
Select item 226640	NM_001458.5(FLNC):c.2265+12C>G	FLNC	Single nucleotide variant (intron variant)	Myofibrillar myopathy 5 +4 more	GBenign
Select item 258133	NM_001458.5(FLNC):c.2266-14G>C	FLNC	Single nucleotide variant (intron variant)	not provided +5 more	GBenign
Select item 258134	NM_001458.5(FLNC):c.2292C>T (p.Pro764=)	FLNC	Single nucleotide variant (synonymous variant)	not specified +5 more	GLikely benign
Select item 258135	NM_001458.5(FLNC):c.2389+12C>T	FLNC	Single nucleotide variant (intron variant)	not provided +5 more	GBenign/Likely benign
Select item 258137	NM_001458.5(FLNC):c.2390-14C>T	FLNC	Single nucleotide variant (intron variant)	Distal myopathy with posterior leg and anterior hand involvement +5 more	GBenign
Select item 258136	NM_001458.5(FLNC):c.2390-13C>T	FLNC	Single nucleotide variant (intron variant)	not specified +4 more	GBenign
Select item 472008	NM_001458.5(FLNC):c.2390-9T>C	FLNC	Single nucleotide variant (intron variant)	Distal myopathy with posterior leg and anterior hand involvement +7 more	GBenign/Likely benign
Select item 972607	NM_001458.5(FLNC):c.2425G>A (p.Val809Met)	FLNC (V809M)	Single nucleotide variant (missense variant)	Distal myopathy with posterior leg and anterior hand involvement +4 more	GUncertain significance
Select item 385981	NM_001458.5(FLNC):c.2490C>T (p.Thr830=)	FLNC	Single nucleotide variant (synonymous variant)	Myofibrillar myopathy 5 +6 more	GLikely benign
Select item 539436	NM_001458.5(FLNC):c.2491G>A (p.Val831Ile)	FLNC (V831I)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +4 more	GUncertain significance
Select item 129083	NM_001458.5(FLNC):c.2501C>T (p.Thr834Met)	FLNC (T834M)	Single nucleotide variant (missense variant)	Cardiomyopathy +6 more	GBenign/Likely benign
Select item 936351	NM_001458.5(FLNC):c.2627G>T (p.Gly876Val)	FLNC (G876V)	Single nucleotide variant (missense variant)	Myofibrillar myopathy 5 +3 more	GUncertain significance
Select item 597034	NM_001458.5(FLNC):c.2733G>A (p.Lys911=)	FLNC	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +5 more	GConflicting classifications of pathogenicity
Select item 1284407	NM_001458.5(FLNC):c.2838T>A (p.Tyr946Ter)	FLNC (Y946*)	Single nucleotide variant (nonsense)	Myofibrillar myopathy 5 +3 more	GPathogenic
Select item 472020	NM_001458.5(FLNC):c.2841C>T (p.Gly947=)	FLNC	Single nucleotide variant (synonymous variant)	Distal myopathy with posterior leg and anterior hand involvement +6 more	GBenign/Likely benign
Select item 382871	NM_001458.5(FLNC):c.2889G>A (p.Pro963=)	FLNC	Single nucleotide variant (synonymous variant)	not specified +7 more	GBenign/Likely benign
Select item 1284391	NM_001458.5(FLNC):c.2982C>T (p.Gly994=)	FLNC	Single nucleotide variant (synonymous variant)	Myofibrillar myopathy 5 +3 more	GLikely benign
Select item 258139	NM_001458.5(FLNC):c.3000T>C (p.Asp1000=)	FLNC	Single nucleotide variant (synonymous variant)	Distal myopathy with posterior leg and anterior hand involvement +6 more	GBenign/Likely benign
Select item 286341	NM_001458.5(FLNC):c.3006G>A (p.Arg1002=)	FLNC	Single nucleotide variant (synonymous variant)	not specified +6 more	GBenign
Select item 539476	NM_001458.5(FLNC):c.3055G>A (p.Gly1019Ser)	FLNC (G1019S)	Single nucleotide variant (missense variant)	Myofibrillar myopathy 5 +5 more	GLikely benign
Select item 671611	NM_001458.5(FLNC):c.3090C>T (p.Pro1030=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +6 more	GLikely benign
Select item 421585	NM_001458.5(FLNC):c.3180del (p.Asp1061fs)	FLNC (D1061fs)	Deletion (frameshift variant)	Distal myopathy with posterior leg and anterior hand involvement +4 more	GPathogenic/Likely pathogenic
Select item 1284696	NM_001458.5(FLNC):c.3259A>C (p.Thr1087Pro)	FLNC (T1087P)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 129084	NM_001458.5(FLNC):c.3297A>G (p.Val1099=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +6 more	GBenign
Select item 451859	NM_001458.5(FLNC):c.3372G>A (p.Thr1124=)	FLNC	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy 26 +5 more	GConflicting classifications of pathogenicity
Select item 392044	NM_001458.5(FLNC):c.3621C>T (p.Asn1207=)	FLNC	Single nucleotide variant (synonymous variant)	Myofibrillar myopathy 5 +8 more	GBenign
Select item 129085	NM_001458.5(FLNC):c.3624G>A (p.Ala1208=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +6 more	GBenign
Select item 129086	NM_001458.5(FLNC):c.3757G>A (p.Val1253Ile)	FLNC (V1253I)	Single nucleotide variant (missense variant)	Cardiomyopathy +6 more	GBenign/Likely benign
Select item 129087	NM_001458.5(FLNC):c.3838C>T (p.Leu1280=)	FLNC	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +6 more	GBenign
Select item 195740	NM_001458.5(FLNC):c.3966C>T (p.Gly1322=)	FLNC	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +7 more	GConflicting classifications of pathogenicity
Select item 129088	NM_001458.5(FLNC):c.3973C>T (p.Leu1325=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +6 more	GBenign
Select item 195741	NM_001458.5(FLNC):c.4022G>A (p.Arg1341Gln)	FLNC (R1341Q)	Single nucleotide variant (missense variant)	Dilated Cardiomyopathy, Dominant +8 more	GConflicting classifications of pathogenicity
Select item 472057	NM_001458.5(FLNC):c.4054C>T (p.Arg1352Cys)	FLNC (R1352C)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +4 more	GConflicting classifications of pathogenicity
Select item 129089	NM_001458.5(FLNC):c.4056C>T (p.Arg1352=)	FLNC	Single nucleotide variant (synonymous variant)	not specified +6 more	GBenign
Select item 386571	NM_001458.5(FLNC):c.4153C>T (p.Leu1385=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +6 more	GLikely benign
Select item 391107	NM_001458.5(FLNC):c.4302C>T (p.Arg1434=)	FLNC	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +7 more	GBenign
Select item 226641	NM_001458.5(FLNC):c.4404T>C (p.Asp1468=)	FLNC	Single nucleotide variant (synonymous variant)	Myofibrillar myopathy 5 +4 more	GBenign
Select item 1284429	NM_001458.5(FLNC):c.4418G>A (p.Gly1473Asp)	FLNC (G1473D)	Single nucleotide variant (missense variant)	Myofibrillar myopathy 5 +3 more	GUncertain significance
Select item 129090	NM_001458.5(FLNC):c.4431G>A (p.Leu1477=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +6 more	GBenign
Select item 383309	NM_001458.5(FLNC):c.4456+13C>T	FLNC	Single nucleotide variant (intron variant)	Myofibrillar myopathy 5 +4 more	GBenign/Likely benign
Select item 1206315	NM_001458.5(FLNC):c.4456+16G>A	FLNC	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy 26 +3 more	GBenign
Select item 501268	NM_001458.5(FLNC):c.4488T>C (p.Asn1496=)	FLNC	Single nucleotide variant (synonymous variant)	not specified +7 more	GConflicting classifications of pathogenicity
Select item 195949	NM_001458.5(FLNC):c.4553A>G (p.Lys1518Arg)	FLNC (K1518R)	Single nucleotide variant (missense variant)	Dilated Cardiomyopathy, Dominant +7 more	GConflicting classifications of pathogenicity
Select item 129091	NM_001458.5(FLNC):c.4700G>A (p.Arg1567Gln)	FLNC (R1567Q)	Single nucleotide variant (missense variant)	not specified +6 more	GBenign/Likely benign
Select item 196015	NM_001458.5(FLNC):c.4737+9_4737+10del	FLNC	Microsatellite (intron variant)	Hypertrophic cardiomyopathy 26 +5 more	GBenign
Select item 383131	NM_001458.5(FLNC):c.4737+15A>G	FLNC	Single nucleotide variant (intron variant)	not specified +5 more	GBenign/Likely benign
Select item 853811	NM_001458.5(FLNC):c.4812G>A (p.Pro1604=)	FLNC	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +4 more	GLikely benign
Select item 775971	NM_001458.5(FLNC):c.4914G>A (p.Lys1638=)	FLNC	Single nucleotide variant (synonymous variant)	Dilated Cardiomyopathy, Dominant +4 more	GLikely benign
Select item 196167	NM_001458.5(FLNC):c.4928-7T>C	FLNC	Single nucleotide variant (intron variant)	Dilated Cardiomyopathy, Dominant +5 more	GBenign
Select item 258144	NM_001458.5(FLNC):c.4947C>T (p.Gly1649=)	FLNC	Single nucleotide variant (synonymous variant)	not specified +7 more	GBenign/Likely benign
Select item 196617	NM_001458.5(FLNC):c.5042C>G (p.Thr1681Arg)	FLNC (T1681R)	Single nucleotide variant (missense variant)	Myofibrillar myopathy 5 +6 more	GBenign/Likely benign
Select item 518183	NM_001458.5(FLNC):c.5124G>A (p.Ala1708=)	FLNC	Single nucleotide variant (synonymous variant)	not provided +5 more	GLikely benign
Select item 472098	NM_001458.5(FLNC):c.5278G>A (p.Gly1760Ser)	FLNC (G1760S)	Single nucleotide variant (missense variant +1 more)	Distal myopathy with posterior leg and anterior hand involvement +5 more	GConflicting classifications of pathogenicity
Select item 572468	NM_001458.5(FLNC):c.5363T>G (p.Val1788Gly)	FLNC, FLNC-AS1 (V1788G +1 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +5 more	GConflicting classifications of pathogenicity
Select item 539475	NM_001458.5(FLNC):c.5367C>T (p.Ile1789=)	FLNC, FLNC-AS1	Single nucleotide variant (synonymous variant)	Myofibrillar myopathy 5 +6 more	GLikely benign
Select item 258148	NM_001458.5(FLNC):c.5398+16T>C	FLNC, FLNC-AS1	Single nucleotide variant (intron variant)	Dilated Cardiomyopathy, Dominant +4 more	GBenign
Select item 1284598	NM_001458.5(FLNC):c.5399-17C>T	FLNC, FLNC-AS1	Single nucleotide variant (intron variant)	Myofibrillar myopathy 5 +3 more	GLikely benign
Select item 290873	NM_001458.5(FLNC):c.5418G>A (p.Ser1806=)	FLNC, FLNC-AS1	Single nucleotide variant (synonymous variant)	not provided +6 more	GConflicting classifications of pathogenicity
Select item 539477	NM_001458.5(FLNC):c.5445C>T (p.Thr1815=)	FLNC, FLNC-AS1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +6 more	GLikely benign
Select item 196888	NM_001458.5(FLNC):c.5578C>T (p.Arg1860Cys)	FLNC, FLNC-AS1 (R1860C +1 more)	Single nucleotide variant (missense variant)	Dilated Cardiomyopathy, Dominant +8 more	GBenign/Likely benign
Select item 287215	NM_001458.5(FLNC):c.5644A>G (p.Ile1882Val)	FLNC, FLNC-AS1 (I1882V +1 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +8 more	GConflicting classifications of pathogenicity
Select item 258149	NM_001458.5(FLNC):c.5669-12C>T	FLNC-AS1, FLNC	Single nucleotide variant (non-coding transcript variant +1 more)	Dilated Cardiomyopathy, Dominant +4 more	GBenign
Select item 129094	NM_001458.5(FLNC):c.5763T>C (p.Thr1921=)	FLNC-AS1, FLNC	Single nucleotide variant (synonymous variant)	not specified +6 more	GBenign
Select item 258150	NM_001458.5(FLNC):c.5766G>A (p.Ala1922=)	FLNC, FLNC-AS1	Single nucleotide variant (synonymous variant)	not provided +7 more	GBenign/Likely benign
Select item 258151	NM_001458.5(FLNC):c.6004+11G>A	FLNC, FLNC-AS1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy 26 +5 more	GBenign
Select item 258152	NM_001458.5(FLNC):c.6004+19G>A	FLNC, FLNC-AS1	Single nucleotide variant (intron variant)	Myofibrillar myopathy 5 +5 more	GBenign

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