2JTF,2EQM


Conserved Protein Domain Family
MBT_PHF20L1-like
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cd20104: MBT_PHF20L1-like 
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malignant brain tumor (MBT) repeat found in PHD finger protein 20-like protein 1 (PHF20L1) and similar domains
PHF20L1 associates with SOX2, antagonizes SOX2 ubiquitination and the sequential degradation induced by MLL1/WDR5 complexes. It binds both monomethylated Lys-42 and Lys-117 in SOX2 and thereby prevents SOX2 proteolysis. PHF20L1 also reads and controls enzyme levels of methylated DNMT1 in cells, thus representing a novel antagonist of DNMT1 degradation. PHF20L1 contains one MBT (malignant brain tumor) repeat. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the MBT repeat of PHF20L1 and similar domains that contains the semi-aromatic cage that may bind methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439094
Aligned: 102 rows
Threshold Bit Score: 60.3297
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of MBT domains with bound methylated lysine peptides
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #  #         # #                   #  #   #                   
2JTF_A         22 FEIGARLEALDYLQ---------KWYPSRIEKIdy--eEGKMLVHFERWshRYDEWIYWds-nRLRPLERPA 81   human
XP_007892025  564 YPSGMKVQVRYGRGrn------qKLYEASIKDCdieggEVLYLVHYCGWnvRYDEWIKAdkivRPADKNVPK 629  elephant shark
XP_029844549  710 WSLDVSIDVGDRVKvkygrgrqlKIYEAKVLRIeeeagDKKFYVHYTGWnmRYDEWVRKn---RIVENVTDK 778  Ixodes scapularis
XP_018097086  421 YPSGTKVQVRYGRGkn------qKLYEASVKDSdveggEVLYLVHYCGWnvRYDEWIKAdkivRPEDKSVPK 486  African clawed frog
XP_005173089  541 YPPGMKVQVRYGRGrs------lKTYDATVKESnleggEVLYLVHYCGWnvRYDEWIKAdkivRPANKNVPK 606  zebrafish
XP_007891497  578 YPSGTKVKVKYGRGkn------qKIYEANIRNSelddgEVIYLVHYYGWntRYDEWVKGd---RIIWPSDRG 640  elephant shark
NP_573332      70 VGIGDKLKVNYHEKksps--shgSTYEAKVIEIsvqrgVPMYLVHYTGWnnRYDEWVPRe---RIAENLTKG 136  fruit fly
NP_001026838  598 SLAGTKVRVKYGKGkt------qKIYEANIKNTetddgEVLYLVHYYGWnvRYDEWVKAd---RIIWPVDKG 660  zebrafish
NP_001012920  572 CLTGTKVKVKYGRGkt------qKIYEASIKSTetddgEVLYLVHYYGWnvRYDEWVKAd---RIIWPVDKG 634  chicken
P29374        573 CLTGTKVKVKYGRGkt------qKIYEASIKSTeiddgEVLYLVHYYGWnvRYDEWVKAd---RIIWPLDKG 635  human

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