2R3A


Conserved Protein Domain Family
SET_SUV39H2
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cd10532: SET_SUV39H2 
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.
Links
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Statistics
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PSSM-Id: 380930
Aligned: 6 rows
Threshold Bit Score: 475.15
Created: 13-May-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens EHMT1 (3HNA) binds SAH and mono-methylated H3k9 peptide.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2R3A_A        44 SDFYYInEYKPAPgi---slVTFGCSCTDCffqKCCPAeagvlLAYNKNQQikippgTPIYECNSRCQCgpDCPNRivQK 120 human
NP_001026541 163 IDFYYInEYKPAPginvingITTGCECSDCpaeKCCPKeagfiLAYNKQKKlkiqpgLPIYECNSFCRCgpDCPNRivQK 242 chicken
Q9H5I1       167 SDFYYInEYKPAPgislvneATFGCSCTDCffqKCCPAeagvlLAYNKNQQikippgTPIYECNSRCQCgpDCPNRivQK 246 human
NP_001091337 163 IDFYYInDYKASPgvntlgeAIVGCDCSDCfngKCCPTeagvlFAYNEHKQlkippgRPIFECNSRCKCgpDCPNRvvQK 242 African clawed ...
XP_006013568 237 LDFHYInQYKASPgiylsteALVGCECSNCflgKCCPLgagvdFAYNEHGQlkikpgQPIYECNSQCKCslECPNRvvQK 316 coelacanth
XP_007883964 166 TDFHYInQYRPTPgieldqePLIGCDCLDCmqgKCCPEeagakFAFSERGQlciepgKPIFECNSSCHCgpQCPNRvvQK 245 elephant shark

Feature 1                      ###                #      #  ## #        ######  #     #          
2R3A_A       121 GTQYSLCIFRTsNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNkGITYLFDLDYeSDEFTVDAARYGNVS 200 human
NP_001026541 243 GTQYSLCIFRTnNGRGWGVKTLQKIKTNSFVMEYVGEVITSEEAERRGQFYDNqGNTYLFDLDYdSDEFTVDAARYGNVS 322 chicken
Q9H5I1       247 GTQYSLCIFRTsNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNkGITYLFDLDYeSDEFTVDAARYGNVS 326 human
NP_001091337 243 GPPYSLCIFRTdNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQQYDSkGITYLFDLDYeADEFTVDAARYGNVS 322 African clawed ...
XP_006013568 317 GTPYSLCIFRTsNGRGWGVQTLQKIKKNSFVMEYVGEVITSEEAERRGQLYDSkGTTYLFDLDYeSDEFTVDATRYGNIS 396 coelacanth
XP_007883964 246 GTRYDLCIFRTrDGRGWGVKTLQSIRKKSFVMEYVGEVITSEEADRRGQLYDSkGVTYLFDLDYvEDEYTVDAGRFGNIS 325 elephant shark

Feature 1        #####       # #            #               # #                         #####    
2R3A_A       201 HFVNHSCDPNLQVFNVFIDNLDtRLPRIALFSTRTINAGEELTFDYQMKGSgr----------------vRTVCKCGAVT 264 human
NP_001026541 323 HFVNHSCDPNLQVFNVFIDNLDlRLPRIALFSTRTIKAGEELTFDYQMKGSidltsdsad-glsssrkriRTVCKCGAVC 401 chicken
Q9H5I1       327 HFVNHSCDPNLQVFNVFIDNLDtRLPRIALFSTRTINAGEELTFDYQMKGSgdissdsid--hspakkrvRTVCKCGAVT 404 human
NP_001091337 323 HFVNHSCDPNLQVFNVFIDNLDvRLPRIALFSTRNIKAGEELTFDYQMKGYgdlstdsid--mspakkrgRIACKCGAAT 400 African clawed ...
XP_006013568 397 HFVNHSCDPNLQVFNVFIENLDlRIPRIALFSTRNIKAREELTFDYQMKGSgdlspesvd--ispakkraRTACRCGSVS 474 coelacanth
XP_007883964 326 HFVNHSCDPNLQVYNVFIDSLDtRLPRIALFSTRAIKAGEELTFDYQMKGSgdtsinessevngparklyRMVCKCGSAS 405 elephant shark

Feature 1             
2R3A_A       265 CRGYL 269 human
NP_001026541 402 CRGYL 406 chicken
Q9H5I1       405 CRGYL 409 human
NP_001091337 401 CRGYL 405 African clawed frog
XP_006013568 475 CRGYL 479 coelacanth
XP_007883964 406 CRGYM 410 elephant shark

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