1BUD,3AIG,1IAG,1HTD,1HTD,1KUG,1WNI,1ND1,1KUK,1BSW,1DTH,4AIG,1QUA,1YP1,1R55


Conserved Protein Domain Family
ZnMc_adamalysin_II_like
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cd04269: ZnMc_adamalysin_II_like 
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Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.
Links
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Statistics
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PSSM-Id: 239797
Aligned: 110 rows
Threshold Bit Score: 123.88
Created: 23-May-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063
  • Structure:1BUD: Deinagkistrodon acutus acutolysin binds water-coordinated Zn
    - View structure with Cn3D
  • Citation:PMID 9784374
  • Structure:3AIG: Crotalus adamanteus adamalysin II binds Zinc and the peptidomimetic inhibitor Pol656
    - View structure with Cn3D
  • Citation:PMID 9521103
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1BUD_A      3 RYMEIVIVVDhsmvkk------yngdsdSIKAWVYEMINTITESYSYlkIDISLSGLEIWSGKDLidv-----easAGNT 71  Deinagkistrodon ac...
DAA01537  213 KNVGIQYTVThelytq------igsnstASIELILIMTSISHSIYKTsgMFVFARAACIWNDKDHysiss--fynnVWRL 284 house mouse
NP_033750 213 KSVGIHYTVThdlfkq------tgsnssTSVELILIMNSISDSIYKIsgLIVYARGVWIWNTKNLhtvpgenphldPWSV 286 house mouse
AAN77878  215 AAIKGHFQAThsvysas-----ggdklsSTVEYLFKVISLMDTYLTNlhMRYYVFLMTVYTEADPfsqd----frvPGGQ 285 house mouse
CAA60663  205 GNIKGHVQCSntyyri-------ygnitTCYIAVVQMFSVIDSIVQNidLRYYIYLLTIYNVRDPapv------nqYGAN 271 crab-eating macaque
XP_548009 196 AMLKGFAQSSnsmyrl-------ynnvtACAKFLISMVSLIDSIYKGlgIRYHLTAVLIFHVRDPvnm------ndYRLP 262 dog
XP_848365 190 MYASHHGQVKalslssnsm-yrvfnnvsKCAQFLIRIFSLIDTFYQAldMNYYIGSMIIYTQEEPaam------nsFHPI 262 dog
DAA01538  215 AAIKGHFQATnsvynsa-----agdklsSTVGYLFQVISLMDTYLTNlhMRYYVFLMTVYTNSDPfrle---favpGGSA 286 house mouse
CAA70328  215 AAIKGQFQATnsiyke-------snnidTAARYLFELLSITDSFLITihMRYYAILLTVFTESDPfale---ytvpGGSI 284 Norway rat
XP_849457 371 KMYASHNGYVkslalsshsmysvfnnvsKCAQFLIRIFSLIDTFYQAldINYYIGSMIIYTQGESaamn---nvhqAHSP 447 dog

Feature 1                                                                              ##  #  
1BUD_A     72 LKSFGEWRAKDLihrisHDNAQLLTatdfdgatIGLAYVASMCNpKRSVGVIQDHss------vnRLVAITLAHEMAHNL 145 Deinagkistrodon ac...
DAA01537  285 MELFGYWKAGYFwh-meHATTALLLgrkl-gntDYAGFQDGICN-PNWGVLYTYVgtn-----hfFLAGSFLAHAVGHLL 356 house mouse
NP_033750 287 MAGFGVWKSKELhd-lyATTAILLAsrp--kntDYGSFQNGLCN-PNWGVLFTYVgkn-----hlFLAGSFLAHAVGHLL 357 house mouse
AAN77878  286 AHTFYERVFYAHf---rPDAGAIINknsp-gddAVNPAERSICS-PSALICLGQHgr------npLFLSIIITNRVGRSL 354 house mouse
CAA60663  272 SAMFTYFKRTFFdtfrvHSSTLLIKeap--hesNYEPQRYSFCT-HLGLLHIGTLgr------hyLLVAVITTQTLMRSM 342 crab-eating macaque
XP_548009 263 AGEYYRYHANNLfr-iiNPSSSFVLvrdgpqdyQNEPTFGGICSaRCLHMIGLLGrh-------yVLLAVIMSQYAARNL 334 dog
XP_848365 263 QSPLARYYRSKLyp-ifLPHSTLIVtkegsldnNTEPIIYGLCK-TQNLLVLEYLdk------hyLILSIIAAQKVGRSL 334 dog
DAA01538  287 YNYYVSVFYNKFk----PDAGVLLNkygp-qdnQVNPAERSICSsLALICIGKYDrn-------pLFLSPIITNRVGRSL 354 house mouse
CAA70328  285 YNYYVSNFFNRLr----PDASTVLNkdgp-sdnDFHPVEQSLCT-PAGLTIVGQHrr------sfLALSVMITNRIAMSL 352 Norway rat
XP_849457 448 LARYYHSKVYPIi----LPHSTLIVi-------KEGPLDNNTEPiLYRFCKMQNLlmlgylgrhyLILSIVAAQKVGRSF 516 dog

Feature 1        #                                                   
1BUD_A    146 GVSHDEg-sCsCGg-kSCIMSPsisdetikYFSDCSYIQCRDYISken-ppCILN 197 Deinagkistrodon acutus
DAA01537  357 NVRHDTp-gCvCFrrsSCLMDEfpt--lhdMISNCSHNELHRRIHdw--dpCLSL 406 house mouse
NP_033750 358 DVSHDTp-gCvCFrrsSCLMDEfpt--lhdMISNCSHNELHRRIHdw--dpCLSL 407 house mouse
AAN77878  355 GLKHDEg-yCiCQrrnTCIMFKnpq--ltdAFSNCSLAEISNILNtpglmpCLFY 406 house mouse
CAA60663  343 GVEYDDn-yCtCQrraFCIMQRypg--itdAFSNCSYGHTQNCFVns--sqCVFE 392 crab-eating macaque
XP_548009 335 GLYYDNa-dCgCQrrsTCIMYRypv--ltdSFSNCSFMHLQNLLSvn--khCLFN 384 dog
XP_848365 335 GLYYDNr-yCvCQrrtTCIMNRymg--ltdAFSNCSFKHVLNILGtik-aeCMYS 385 dog
DAA01538  355 GLKYDEg-yCvCQrrnTCIMFRhpq--ltdAFSNCSLAEISNILNtpglmpCLFY 406 house mouse
CAA70328  353 GIKADDetyCiCHrrtTCIMYKnpe--itdAFSNCSLVQINQILNtpgtmsCLFY 405 Norway rat
XP_849457 517 GLYYDNr-fCiCQrrsICIMHKiig--ltdSFSNCSFMHLQHIVGsgk-seCLYS 567 dog

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