2W5Z,2W5Y


Conserved Protein Domain Family
SET_KMT2A_2B
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cd19170: SET_KMT2A_2B 
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).
Links
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Statistics
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PSSM-Id: 380947
Aligned: 16 rows
Threshold Bit Score: 278.506
Created: 7-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2W5Z; Homo sapiens MLL1 binds cofactor product S-adenosylhomocysteine and histone peptide through its SET domain, contacts at 4A.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                               ####                #                        ######       
2W5Z_A         39 MPMRFRHLKKTSKEAVGVYRSpIHGRGLFCKRNIDAGEMVIEYaGNVIRSIQTDKREKYYDSkgiGCYMFRIDdSEVVDA 118  human
P20659       3575 MAMKYRTLKETYKDYVGVFRShIHGRGLYCTKDIEAGEMVIEYaGELIRSTLTDKRERYYDSrgiGCYMFKIDdNLVVDA 3654 fruit fly
XP_002401626  885 MAMRFRHLKNTAKEAVGVYRSsIHGRGLYCKRNIDGGEMIIEYaGEVIRAALTDKREKYYESkgiGCYMFRIDdHEVVDA 964  black-legged ...
ESO01296      195 MAMRFRQLKSLTREIVGVYRSsIHGRGLFCKKDIDAGEMIIEYsGEVIRAGLTDKREKMYEGrgiGCYMFRKDlDHVIDS 274  Helobdella ro...
EDO30857      137 MRYRHLKQNNYNKGTIAVFRSgIHGRGLYCTRHIAAGEMVIEYsGMLIRSTLTDKREAYYESkgiGCYMFRIDgTYVVDA 216  starlet sea a...
EFX77649       57 MTVRFKHLRQVAKNSVGVYRShIHGRGLFCKRDIECGEMVVEYaGQVIRSVLCDKREKEYEAkgmGCYMFRIDeQTVVDA 136  common water ...
XP_002112190    1 MAMRYRHLAATAKETVGVYRSdIHGRGLFCKRIIEAGEMIMEYaGTKIRSILTDKQEKYYEGkglGCYMFRIDrDEVIDA 80   Trichoplax ad...
XP_023932376 5201 MAMRFRHLREHANEAVGAYRSqIHGRGLFCKRDIDDGEMVVEYaGEVIRSVLTDQRERYYESkgiGCYMFRIDdFDVVDA 5280 Lingula anatina
XP_019857006 1180 VAMRYRACQRMYRENVGVFGShIHGLGLFCLQEIDSGDMVIEYaGTVIRSTLTDYRERFYESrgiGCYMFRIDsDEVVDA 1259 Amphimedon qu...
XP_009013499   16 LSSRFHSMRALLRCTTVVQASaIHGRGLFALRGLEAGEMVIEYcGELIRPVLTDAREKLYEAkniGCYMFKIDeLNVVDA 95   Helobdella ro...

Feature 1               ######       ###        #               ######        ####        # 
2W5Z_A        119 TMhGNAARFINHSCePNCYSRVINIdgqkHIVIFAMRKIYRGEELTYDYKFPiedasnKLPCNCGAKKCRKFLN 192  human
P20659       3655 TMrGNAARFINHCCePNCYSKVVDIlghkHIIIFALRRIVQGEELTYDYKFPfe--deKIPCSCGSKRCRKYLN 3726 fruit fly
XP_002401626  965 TMhGNAARFINHSCePNCYSKVITVdnkkHIVIFALRSILKGEELTYDYKFPie--evKIPCSCGSRRCRKFLN 1036 black-legged tick
ESO01296      275 TVmGNASRFINHSCePNCYSKVIHVdnrkHIVIFAQRDIKRGEELTYDYKFPie--evKIPCLCGSRKCRKYLN 346  Helobdella robusta
EDO30857      217 TTsGNAARFINHSCePNCYSRVVTIdgnkKILIFASKSISRGEELTYDYKFPle--deKLPCHCKSKRCRKYLN 288  starlet sea anemone
EFX77649      137 TVhGNAARFINHSCePNCYSRIVDIfgkkHIIIFALRRILRGEELTYDYKFPle--dvKIRCTCGSRKCRKYLN 208  common water flea
XP_002112190   81 TLsGNAARFINHSCdPNCYCKIVPIdnikKIIIFALRRIYPGEELTYDYNFAke--diKLPCNCSSKKCRKFLN 152  Trichoplax adhaerens
XP_023932376 5281 TVhGNAARFINHSCdPNCYSKVINVdgkkHIVIFALRPIKAGEELTYDYKFPye--evKIPCTCASKKCRKYLN 5352 Lingula anatina
XP_019857006 1260 TMsGNMARFINHSCePNCYSKVVAVdgqkKIMIFALRRIVPGEELTYDYKFPie--eaKIPCKCGSARCRKTLN 1331 Amphimedon queensla...
XP_009013499   96 TMkGNSARFINHSCePNCYSRVCQIegrkRIIICTSRYIRRGEELTYNYKFPie--enKIICRCQSKKCKGYMN 167  Helobdella robusta

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