2EP4


Conserved Protein Domain Family
RING-H2_RNF24
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cd16675: RING-H2_RNF24 
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RING finger, H2 subclass, found in RING finger protein 24 (RNF24) and similar proteins
RNF24 is an intrinsic membrane protein localized in the Golgi apparatus. It specifically interacts with the ankyrin-repeats domains (ARDs) of TRPC1, -3, -4, -5, -6, and -7, and affects TRPC intracellular trafficking without affecting their activity. RNF24 contains an N-terminal transmembrane domain and a C-terminal C3H2C3-type RING-H2 finger.
Links
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Statistics
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PSSM-Id: 438337
Aligned: 7 rows
Threshold Bit Score: 103.939
Created: 24-Mar-2015
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:2EP4; Homo sapiens RNF24 binds two Zn2+ ions through its RING-H2 finger.
    - View structure with Cn3D
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #              # #  #  #          #  #           
2EP4_A        16 ELCAVCLEDFKpRDELGICPCKHAFHRKCLIKWLEVRKVCPLCNMPVLQLAQLS 69  human
NP_001007353  76 EICAVCLEEFKqKDELGICPCKHAFHRKCLIKWLEVRKVCPLCNMPVLQLAQQQ 129 zebrafish
XP_006012605  92 EICAVCLEEFKpKDELGICPCKHAFHRKCLIKWLEVRKVCPLCNMPVLQLAQQH 145 coelacanth
XP_007896242 157 EICAVCLEEFKtKDELGICPCKHAFHRKCLIKWLEVRKVCPLCNTPVLQNNPEQ 210 elephant shark
Q9Y225        76 ELCAVCLEDFKpRDELGICPCKHAFHRKCLIKWLEVRKVCPLCNMPVLQLAQLH 129 human
XP_018082482  86 EICAVCLEEFKpKDELGICPCKHAFHRKCLIKWLEVRKVCPLCNMPVLQLAQLH 139 African clawed frog
XP_004936334  83 EICAVCLEEFKpKDELGICPCKHAFHRKCLIKWLEVRKVCPLCNMPVLQLAQLH 136 chicken

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