1PEG,1ML9


Conserved Protein Domain Family
SET_SUV39H_DIM5-like
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cd19473: SET_SUV39H_DIM5-like 
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins
This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.
Links
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Statistics
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PSSM-Id: 380996
Aligned: 19 rows
Threshold Bit Score: 449.845
Created: 6-Aug-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1PEG; Neurospora crassa Dim-5 binds SAH and mono-methylated H3k9 peptide, contacts at 4A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1PEG_B        25 PNFRFIdHSIIGKnvpvadqsFRVGCSCAsdeECmy-------sTCq-CLDemapdsde--------------------- 75  Neurospora crassa
CCD47746      79 SDFTFIeKSILREgvsradpeFRVGCECSh--SChg-------mTCh-CLQdsevd------------------------ 124 Botryotinia fuc...
XP_003709573  59 PDFRFIsERILGEgvsraeasFLSGCECTsneDCmy-------gGCe-CLSdlpdsglesdgd--------------adf 116 Magnaporthe ory...
EPE10588      59 NDFRFItASILTGgveaasenFRSGCGCLdsvACry-------dGCe-CLSdmwweenesarlglhgsdsdsdseteagn 130 Ophiostoma pice...
CCU75462      68 DNFEFIeKNIIRNgveladeeFQAGCTCEtsfDClk-------aGCh-CLDdietsd----------------------- 116 Blumeria gramin...
XP_007293640  63 KDFVFIeKSIPVEgvrfaedeYLNGCECEsdaQCmg-------sMCdpCLGdvdrv------------------------ 111 Marssonina brun...
XP_018062352  52 ESFQFVnKVVPSAdvpliaeeFVSSCECVa-dHCvt-------qNCt-CLSdidas------------------------ 98  Phialocephala s...
CZT53234      83 EDFTFIeQNILRDgvhlaeemFLAGCECDddhDCmt-------aACy-CLQdvqnd------------------------ 130 leaf blotch of ...
CZR62020     205 ETFKFVdRVVPSAniiltpddFYIGCNCTi-dLCtt-------gHCl-CQEdvdis------------------------ 251 Phialocephala s...
OWP05784      65 QDFRFIeENVLREgvqpadaaFESGCNCTddvQCmlmtadndpnGCl-CLQdvdren----------------------- 120 Marssonina coro...

Feature 1                                                                              ###       
1PEG_B        76 eadpytrkKRFAYYSQGakkgllrdrvlqsqEPIYECHQGCACs--kDCPNRvvERGRTVPLQIFRTk-dRGWGVKCPVn 152 Neurospora crassa
CCD47746     125 ----lpdhNVYAYQAGGnsegclkeqlldskAPIYECHEACACd--eTCDNRivARGRRVPLQVFRTe-nRGWGVRSKVp 197 Botryotinia fuc...
XP_003709573 117 rrsrnnriKKFAYYSSGeragllresyldtrTAIYECHEQCSCg--pDCPNRvvERGRTLPLQIFRTddgRGWGVRATVd 194 Magnaporthe ory...
EPE10588     131 rrqrqhkrAKYVYHTRGekagllrsrfldsrEPIYECHEACACsstnDCANRvvERGRRIPLQIFRTp-dRGWGVRTLFa 209 Ophiostoma pice...
CCU75462     117 --medenySINAYHVVGrrkgclrgemlssrMPIYECNRQCSCp--dDCPNKvvSRGRQLPLQIFRT---VNRGLRSTEd 189 Blumeria gramin...
XP_007293640 112 ----pkggKPGAYHVSGdkkgclrgwmlesrLPIYECHEKCTCs--dKCPNRvvGRGRKVALQIFPTs-gRGWGVKSTEd 184 Marssonina brun...
XP_018062352  99 ---rlpglKKNAYHATGqlrsa----ylnghYPIYECGDKCKCg--qNCPNRvvQRGRTVCLQIFKTddgRGWGVKTLSp 169 Phialocephala s...
CZT53234     131 ----dpgaKQNAYHIVGdrkgclrghmlssrKPIYECHKRCGCs--eNCPNRvvGAGRKVNLQIFPTsddRGWGVRTTEd 204 leaf blotch of ...
CZR62020     252 ----glghKVNAYHGSGvkngrlrthyingnFPIYECGPSCRCp--aTCPNRvvQQGRKVKLQIFKTddgRGWGVRSLDp 325 Phialocephala s...
OWP05784     121 ---maigaKLNAYHVFGqragclrghklesrDPVYECNARCSCs--qNCPNRvvGNGRKVNLQIFNT---TDGRVRATEd 192 Marssonina coro...

Feature 1                 #      #  ## #           #####                   #          #####      
1PEG_B       153 IKRGQFVDRYLGEIITSEEADRRRAESTiarrKDVYLFALDKFsdpdsldpllagqPLEVDGEYMSGPTRFINHSCDPNM 232 Neurospora crassa
CCD47746     198 IKAGAFIDCYIGEIITAQEAERRRDNAIisrrKDLYLFSIDKFtdpdslnetlrgdPYVIDGEFYAGPSRFFNHSCEANM 277 Botryotinia fuc...
XP_003709573 195 IKCGQFVDTYIGEVITDSEAVERRKATRk---KDLYLFDLDKFweviq----ddqsRLVIDGEYRSGPSRFFNHSCDPNM 267 Magnaporthe ory...
EPE10588     210 IEKGQFVDRYVGEILTAQEAQRRRADSKmarrKDVYLFALDKFsdadsldsrlagpPLECDGEFRAGPTRFINHSCSPNL 289 Ophiostoma pice...
CCU75462     190 IKQGQFVGNYVGELITSDEANWRRAQSTksqkKDVYLFALDKFtdpnssderlrgePYEIDGEYFAGPTRFINHSCDPNL 269 Blumeria gramin...
XP_007293640 185 IKRGQFVGEYVGEIITPAEANRRRQAATdrkkKDIYLFALDKFqdresydqrlrgePYEIDGEFKSGPTRFINHSCEPNL 264 Marssonina brun...
XP_018062352 170 IIRGYFVDCYFGELLTPDEAQARRDQASsvqqKDVYLFALDKFtdirsp-dprlhaPYEIDGEFISGPTRFINHSCDPNL 248 Phialocephala s...
CZT53234     205 IKRGQFVGCYVGEIITSTEARRRREAGShlthKDVYLFALDKFsdpdsqdprlqgdPYEIDGEFFSGPTRFINHSCDPNL 284 leaf blotch of ...
CZR62020     326 IKKGQFVDTYVGELLTPLEAQARRDQAEssqaKDVYMFALDKFsndddaddrlhgdPYEIDGEFMSGPTRFINHSCVPNL 405 Phialocephala s...
OWP05784     193 IRRGQYVGSYVGEVITPAEADRRRDGAGerkkKDIYLFALDKFsqdsp----dsnkAYEIDGEYMSGPTRFINHSCSPNL 268 Marssonina coro...

Feature 1         # #            #               # #                                           
1PEG_B       233 AIFARVGDHadkhIHDLALFAIKDIPKGTELTFDYVNGltglesdah---------dpskisemTKCLCGTAKCRGYL 301 Neurospora crassa
CCD47746     278 RIFARVGDYseknLHDLAFFAIEDIRPMTELTFDYVDGkddg------------------eqgsEKCLCGAKSCRGWL 337 Botryotinia fucke...
XP_003709573 268 RIFARVGAHaelnLHDLAFFAIRDISNGEELTFDYVDGqvlpd----------------gesldDECLCKSTNCRGVL 329 Magnaporthe oryza...
EPE10588     290 RIFARVGDHadkhIHDLAFFAVKPIEAGEELTFDYVDGtldlvqda-----------rrrvegmTPCLCKSPKCRKYL 356 Ophiostoma piceae...
CCU75462     270 RIFAVVRDLankpFHDLCFFALREIPRFTELTFDYAGGvrgedkdv-----------dqkeagmTRCLCGASNCRDWL 336 Blumeria graminis...
XP_007293640 265 RIFAVVTAHankpFHQLCFFAAKDIPRETELTFDYTDGvtdarmdve--------eaiaqdkelTKCLCGTPSCRGYL 334 Marssonina brunne...
XP_018062352 249 RIFAVVKNSadqpFHSLAFFALENIAPNTELTFDYLDGitgdg----------------ddkekTKCLCGAENCRGYL 310 Phialocephala sco...
CZT53234     285 RIFAVVTDHankpFHGLAFFALRDIDKDSELTFDYTDGvsdrkddrglde---ltdeeranivlTRCLCGADNCRGYL 359 leaf blotch of ba...
CZR62020     406 RNFAVVKNVadrpFHGLAFFALDDIPPNTELTFDYLDGvtsgta--------------eenktkKKCLCGAGKQCRGY 469 Phialocephala sub...
OWP05784     269 RIFAVVNELankaLHGLCFFATKEIPRNTELTFDYTDGvkrsdevagtgrkfedmsaseknkelFPCLCGASNCRGYL 346 Marssonina corona...

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