4DVQ,4ZGX


Conserved Protein Domain Family
CYP11B

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cd20644: CYP11B 
Click on image for an interactive view with Cn3D
cytochrome P450 family 11, subfamily B subfamily
Cytochrome P450 11B (CYP11B) enzymes catalyze the final steps in the production of glucocorticoids and mineralocorticoids that takes place in the adrenal gland. There are two human CYP11B isoforms: Cyb11B1 (11-beta-hydroxylase or P45011beta), which catalyzes the final step of cortisol synthesis by a one-step reaction from 11-deoxycortisol; and CYP11B2 (aldosterone synthase or P450aldo), which catalyzes three steps in the synthesis of aldosterone. The CYP11B subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410737
Aligned: 7 rows
Threshold Bit Score: 748.977
Created: 25-Sep-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                              #                  ##      #   #          
4DVQ_A        46 FQELGPIFRYNlggpRMVCVMlPEDVEKLQQVDSLHPCRmilEPWVAYRQHRGhkcGVFLLNGPEWRFNRLRLNPDVLSP 125 human
4ZGX_A        49 FQELGPIFRYNlggpRMVCVMlPEDVEKLQQVDSLHPCRmilEPWVAYRQHRGhkcGVFLLNGPEWRFNRLRLNPDVLSP 128 human
AAA35741      72 FQELGPIFRYNlggpRMVCVMlPEDVEKLQQVDSLHPCRmilEPWVAIRQHRGhkcGVFLLNGPEWRFNRLRLNPDVLSP 151 human
XP_005291229  81 FQRLGPIYRETvgtyNCVNVLlPRDAAQLFQSEGIFPRRmgiESWIAHRQLRNhkcGIFLLNGEEWRSDRLILNKEVISP 160 western painted...
Q92104        89 FQNLGPIYREKlgthNSVNIMlPQDVARLFQSEGIFPRRmtmEAWSKHRELRNhkqGVFLLNGEAWRSDRIILNKEVLSL 168 bullfrog
AAI55807     183 FRRLGPIYREHlgsqSSVNIMlPMDTGELFRSEGLHPRRmtlQPWATHRETRRhskGVFLKNGTEWRADRLLLNREVMVS 262 zebrafish
P15538        72 FQELGPIFRYDlggaGMVCVMlPEDVEKLQQVDSLHPHRmslEPWVAYRQHRGhkcGVFLLNGPEWRFNRLRLNPEVLSP 151 human
Feature 1                                                                                        
4DVQ_A       126 KAVqrFLPMVDAVARDFSQALKKKVLqnarg-----sltlDVQPSIFHYTIEASNLALFGERLGLvghspssaSLNFLHA 200 human
4ZGX_A       129 KAVqrFLPMVDAVARDFSQALKKKVLqnarg-----sltlDVQPSIFHYTIEASNLALFGERLGLvghspssaSLNFLHA 203 human
AAA35741     152 KAVqrFLPMVDAVARDFSQALRKKVLqnarg-----sltlDVQPSIFHYTIEASNLALFGERLGLvghspssaSLNFLHA 226 human
XP_005291229 161 AGTrkFLPFLNAVAQDFVTLMHQRISkntrr-----sltiDLYSDLFRFTLEASSYALYGERLGLleespnaeSQRFISA 235 western painted...
Q92104       169 AGVkkFLPFLDEAAADFVTFMKKRMSkntrg-----sltvDLYADLFRFTLEASSYVLYGQRLGLleehpnadTLRFISA 243 bullfrog
AAI55807     263 SSVhrFLPLLDEVAQDFCRSLRRRVQadgfekagqhtltlDPSPDLFRFALEASCHVLYGERIGLfsscpsdeSERFISA 342 zebrafish
P15538       152 NAVqrFLPMVDAVARDFSQALKKKVLqnarg-----sltlDVQPSIFHYTIEASNLALFGERLGLvghspssaSLNFLHA 226 human
Feature 1                                                                                        
4DVQ_A       201 LEVMFKSTVQLMFMPrslsrwispKVWKEHFEAWDCIFQYGDNCIQKIYQelafn----rpqhyTGIVAELLLKAelsLE 276 human
4ZGX_A       204 LEVMFKSTVQLMFMPrslsrwispKVWKEHFEAWDCIFQYGDNCIQKIYQelafn----rpqhyTGIVAELLLKAelsLE 279 human
AAA35741     227 LEVMFKSTVQLMFMPrslsrwispKVWKEHFEAWDCIFQYGDNCIQKIYQelafn----rpqhyTGIVAELLLKAelsLE 302 human
XP_005291229 236 VETMLRTTLPLLFIPpglmrwvntKLWRDHIEAWDTIFKHADKCIQNIYQefclg----qprkySGIMAELLMQAelpLD 311 western painted...
Q92104       244 VETVLKTTLPLLYYPhqilqlfqtRLWNEHMHAWDVIFEQADRCIQNIYQeyclg----qergySGIMAELLLQAelpLD 319 bullfrog
AAI55807     343 VERMLATTPPLLYLPprlllrlraSLWTTHATAWDDIFSHAEQRIQRSYQrlqarpsaapdcsfPGVLGKLMEAGqlsLE 422 zebrafish
P15538       227 LEVMFKSTVQLMFMPrslsrwtspKVWKEHFEAWDCIFQYGDNCIQKIYQelafs----rpqqyTSIVAELLLNAelsPD 302 human
Feature 1                #  ##  ##                                                              #
4DVQ_A       277 AIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAasisehpqkattelPLLRAALKETLRLYPVGLFL 356 human
4ZGX_A       280 AIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAasisehpqkattelPLLRAALKETLRLYPVGLFL 359 human
AAA35741     303 AIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRKESLAAAasisehpqkattelPLLRAALKETLRLYPVGLFL 382 human
XP_005291229 312 SIKANITEFTAGGVDTTAMPLLFTLFELARNPSVQTAIRQEIAEAEsqgprelskvlnsmPLLKSALKETLRLYPVGITV 391 western painted...
Q92104       320 SIKANITELMAGGVDTTAMPLLFTLFELARNPSVQRELREEIRKAEaqnpndlnqllnslPLLKGAIKETLRLYPVGITV 399 bullfrog
AAI55807     423 LIRANITELMAGGVDTTAVPLQFALFELARNPDVQECVRAQVLSSWqqasgdplkalqgaPLLKGTIKETLRLYPVGITV 502 zebrafish
P15538       303 AIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAasisehpqkattelPLLRAALKETLRLYPVGLFL 382 human
Feature 1         #                                                           ####  ### #   #    
4DVQ_A       357 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDirg--sgRNFHHVPFGFGMRQCLGRRLAEAEM 434 human
4ZGX_A       360 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDirg--sgRNFHHVPFGFGMRQCLGRRLAEAEM 437 human
AAA35741     383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDirg--sgRNLHHVPFGFGMRQCLGRRLAEAEM 460 human
XP_005291229 392 QRYPTKDVVLQNYRVPAGTLCQVGLYAMGRSPEVFSNPERYDPMRWLSke----dNSFKALAFGFGARQCIGRRLAETEM 467 western painted...
Q92104       400 QRHLIKDIVLHNYHIPAGTLVQVGLYPMGRSPLLFQDALRYDPARWLKre----dTNFKALAFGFGSRQCIGRRIAETEI 475 bullfrog
AAI55807     503 QRYPVRDIVLQNYHVPAGTLVQVCLYPLGRSAEVFSRPECFDPSRWSAdadagsaGGFRSLAFGFGSRQCVGRRIAENEM 582 zebrafish
P15538       383 ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDirg--sgRNFYHVPFGFGMRQCLGRRLAEAEM 460 human
Feature 1                                               
4DVQ_A       435 LLLLHHVLKHFLVetlTQEDIKMVysFILRPGTSPLLTF 473 human
4ZGX_A       438 LLLLHHVLKHFLVetlTQEDIKMVysFILRPGTSPLLTF 476 human
AAA35741     461 LLLLHHVLKRFLVetlTQEDIKMVysFILRPGTSPLLTF 499 human
XP_005291229 468 MLFLMHVLRNFRIdtvSKADIKTVfgFILMPEKPPLLTF 506 western painted turtle
Q92104       476 TLFLMHMLKNFQIdtvSKDDIKTVfgFILMPEKPPLLTF 514 bullfrog
AAI55807     583 QLLLMHILRTFKLtvsSTEELSTKytLILQPECPPRITF 621 zebrafish
P15538       461 LLLLHHVLKHLQVetlTQEDIKMVysFILRPSMFPLLTF 499 human

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