Conserved Protein Domain Family
NPBW
?
pfam15180: NPBW (this model, PSSM-Id:405799 is obsolete and has been replaced by 464547)
Neuropeptides B and W
The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organisation of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.
Links
?
Statistics
?
PSSM-Id: 405799
Aligned: 20 rows
Threshold Bit Score: 97.8342
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
EGW04445      18 LLPLLLVLLLPLPAGAWYKHVASPRYHTVGRASGLLMGLRRSPYLWRRALGGAVGPLSRDTlvp---------------g 82  Chinese hamster
XP_015150919   7 LALAVAVALLCRPAAPWYRQAAAPLSYPVGRASGLLSGLRL-PYSRRSDSEGAAERRPPALhpgs--------------a 71  chicken
ALD51507       9 PVLVVSLLAAGGPSEAWYKQAAGPSYYSVGRASGLLSGIRRSPYVRRAEP--EPADSDEPAdenafaq-------ltaqn 79  three-spined st...
XP_003450170  10 PIVVISVLVACSPTEAWYKQVAGPTYYSVGRASGLLSGIRRSAYVRREEP--HHADTDESAtnnvfse-------ipass 80  Nile tilapia
NP_001120841  10 VFVAVSILISSHPTDAWYKQSTGPSYYSVGRASGLLSGIRRSPYVRRSEG-ESALDSGETPgvsnsvlaelsssnsgrqt 88  zebrafish
XP_005989170  13 VCVAISLLISCQPSEAWYKQATGPSYYSVGRASGLLSGIRRSPYIRRSES-ETGTETGDTTgnnlvse--------prqt 83  coelacanth
XP_006635208  13 VVAAISMLISCHPTAAWYKQATGPSYYSVGRASGLLSGIRRSPYIRRSEP-EAMAESGESTgnfmtemg-----sqarqt 86  spotted gar
Q4S001        10 VCVAVSLLISGDLVEAWYKQSTGPSYYSVGRASGLLSGIRRSPYARRSESEETMLDSEDAPgnsvtpe--------nrqi 81  spotted green p...
XP_027873560  12 VCVGVSLLISCQSVEAWYKQVTGPSYYSVGRASGLLSGIRRSPTVRRAESEETVMDSGEAAgnnliqe-------tnkqi 84  Monterrey platy...
XP_004066211  10 VCVGVSLLVSCHSAEAWYKQSTGPIFYPVGRASGLLSGIRRSPYVRRAESEEVLADSKEAAensvthd-------asrqi 82  Japanese medaka

EGW04445      83 pvTGSTLPLLPSPVQELWETR-----RGSWRAGLPVYeprsprdlerarqpeqsLSLRSWISAE 141 Chinese hamster
XP_015150919  72 apLRTAVPCVTDVDPELRSCRplsgvPGALQCRVAVT-----------------VSLVSTECAG 118 chicken
ALD51507      80 fiLKTMPVCIKDISPDLQSCElq-eiTGSFKCKADIF-----------------LTLDSADCGg 125 three-spined stickleback
XP_003450170  81 siLKTMPVCIKDITPNLQSCEriqdiKASFRCKADVF-----------------LSLDSSDCEa 127 Nile tilapia
NP_001120841  89 pvLKNMAICVKDISPNLQSCEllqdgSSSFRCKADVF-----------------LSLDSLDCFT 135 zebrafish
XP_005989170  84 aiLKSMAICVKDISPNLQSCEllqdgMNTFQCKADVY-----------------LSLDSQDCMN 130 coelacanth
XP_006635208  87 afLKNMAVCVKDISPNLQSCElvqdgMSTFQCKADVY-----------------LSLDSQDCVN 133 spotted gar
Q4S001        82 slLKSMAICVKDISPNLKSCEllrdgTGTFQCKADVF-----------------LTLDSLDCLS 128 spotted green pufferfish
XP_027873560  85 svLKNMAICLKDISPNLKSCEllqdgTGTFQCKADVF-----------------LTLDSLDCLS 131 Monterrey platyfish
XP_004066211  83 saLKDMAICVKDVSPNLKTCEllrdgTGTFQCKADVF-----------------LTLDSLDCLS 129 Japanese medaka
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap