Conserved Protein Domain Family
HRG
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pfam16954: HRG (this model, PSSM-Id:407172 is obsolete and has been replaced by 465321)
Haem-transporter, endosomal/lysosomal, haem-responsive gene
HRG1 is a family of conserved, membrane-bound permeases that reside in distinct intracellular compartments and bind and transport haem in metazoa. These proteins carry four transmembrane domains, 4xTMs, modelled here in two pairs, the two N-terminal and the two more C-terminal.
Links
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Statistics
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PSSM-Id: 407172
Aligned: 42 rows
Threshold Bit Score: 25.7605
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CAP26372      80 QLMIWPNIFIGLLGLIGCLVCYIIAGITHQga------gSIQamygenlwftGSWSLVITK------W 135 Caenorhabditis briggsae
XP_003973669   7 HISIAYASFGMLMGFSAFLTWNIA--YIQPwtaamgglsGVL----------ALWTLITHVmylqdlW 62  torafugu
XP_007249183   7 yISLSYSCVGVLVGFSAFLVWNFA--YKQPwtaamgglaGVL----------ALWTLVTHTmylqdyW 62  Mexican tetra
XP_003963508   7 YISIGYATFGTLVGLSAFLVWNIA--YKQPwtaamgglsGVL----------ALWALVTHImyvqdyW 62  torafugu
XP_005798026   7 HVSVAYSSLGVILGVSAFLVWNIV--YKQPwtgatgglsGVL----------ALWTLITHVmylqdyW 62  southern platyfish
XP_005061775   8 ALRVAYASFGALSGLSAFCAWSVVPALRQPstaaagglsGVL----------ALWALITHVmylqdyW 65  Collared flycatcher
Q5ZHU0         8 ALRLAYAAAGALMGFSAFFTWSLAPAFRQPataaagglsGVL----------ALWALITHVmyvqdyW 65  chicken
XP_003252283   9 GLRAAYSGISSVAGFSIFLVWTVV--YRQPgtaamgglaGVL----------ALWVLVTHVmymqdyW 64  northern white-cheeked gibbon
XP_002712714   9 gLRAAYAGVSSVAGFSIFLVWTVV--YRQPataamgglaGVL----------ALWVLVTHImykqdyW 64  rabbit
NP_001015946   8 WIRIIYAATGTLFGLSAFLVWNVA--FVQPwtaamgglsGVL----------ALWALITHImyvqdfW 63  tropical clawed frog
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