5KO7


Conserved Protein Domain Family
iodotyrosine_dehalogenase

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cd02144: iodotyrosine_dehalogenase 
iodotyrosine dehalogenase
Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.
Statistics
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PSSM-Id: 380320
Aligned: 87 rows
Threshold Bit Score: 211.627
Created: 13-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
FMN bindingdimer interface
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:FMN binding site [chemical binding site]
Evidence:
  • Structure:5KO7: Haliscomenobacter hydrossis nitroreductase binds two molecules of FMN, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ### #                      #####                                         
5KO7_A        27 YYQFMDHRRTVREFsnraiPLEVIENIVMTAstAPSGAHKQPWTFVVVSDPQIKAKIRQAAEKEEFESYngrmsnewle- 105 Haliscomenobact...
XP_022100270  92 FYREMDTRRSVRDIsdkpvPLEVIENCIRMAgtAPSGAHMQPWTFAVLSNPQVKLEVRLIIEEEERMNYekrmsaqwlh- 170 crown-of-thorns...
XP_014153824 100 HYTLMNNRRSVRDFstedvPREVIDNIIRVGgtGPSGAHTEPWTYVVVRSAEKKREIREIIEAEEKVNYarrmgekwvd- 178 Sphaeroforma ar...
XP_002768445  91 FLDLMNTRRSIRFYskddvPMDIIMAAVRTActAPSGAHLQPWTFVIVHNQKAKDKIRDVVEREEQLNYdrrmrrswvn- 169 Perkinsus marin...
NP_498712    128 FYEEMKMRRSCRQFssrdvPLKVIQNLLKTAgtSPSVGNLQPWTFCVVSSDSIKTMIRKILEADERDNYvsrkkgaswvv 207 Caenorhabditis ...
VDM40254     116 FYEKMKRRRSVRSFstrpvSAKLILNLIKTAgtAPSGANMQPWTFCVVGKAEIKSRIRAIVEAEEQVNYsrrvgarwvl- 194 dog roundworm
GCF55272     109 FYALLNKRRSVRFIsdepvPREVIDNVIKAAgtAPSGAHTEPWTFVVVQDPEIKHNIRKIIEEEEEINYkkrmgdqwvh- 187 Paroedura picta
XP_024499781 209 FYETMKLRRSIRCFssksiPFKVIQNIIKTAgtCPSGSNNQPWLFCIVGNEQLKIKIRKIVENEEQNSYtrrmgakwvl- 287 Strongyloides r...
VBB27392     104 FYENMKMRRCVQEFsprpvPSKLIQNIIKSAgtAPSAGNLQPWMFCVVSSYGLKAEIRKIVEEEERNTYskkmgadwvl- 182 Acanthocheilone...
XP_019860294   8 FYQSLNKRRSIRQIssrpvPVNIIKNVIRTAgtSPSGAYSEPWVFVVIKDPGVKSKIRDIIEQEEYLNYnhrmgekwvn- 86  Amphimedon quee...
Feature 1                                                                            #  ##  #    
5KO7_A       106 dlqpfgtdwhKPFLEIAPYLIVVFRKaydvlp----------------------------dgtqrKNYYVQESVGIACGF 157 Haliscomenobact...
XP_022100270 171 dleklrltwsKPYLTRAPYIIVVFKQlfrvte----------------------------egkktTNYYQEISASIATGF 222 crown-of-thorns...
XP_014153824 179 dlshigttwsKPYLEECPYIIIVFKSahsknp----------------------------dgskkIHYYHEISSSIGVGF 230 Sphaeroforma ar...
XP_002768445 170 dvapmafqvaKPYLSEAPYLIVMMKQshrvdp---------------------------ttgnrqEHYYVEQSCGIAAGM 222 Perkinsus marin...
NP_498712    208 dvsqlqdtwrRPYITDAPYLLIVCHEifrdvh----------------------------skterVFHYNQISTSIAVGI 259 Caenorhabditis ...
VDM40254     195 dvahlsvnwcKPYLTEAPFLIVIMKQtyqlda----------------------------ngerhPTYYNEISVSIAAGL 246 dog roundworm
GCF55272     188 dlkrlrtnwiKEYLDTAPYLILLFKQvygmlp----------------------------sgkkkTHYYNEISVSIACGI 239 Paroedura picta
XP_024499781 288 nvndltinwnKPYLTEAPYLIVVMRQvytvnk----------------------------ngekcVVDFSELSSSIAVGF 339 Strongyloides r...
VBB27392     183 diaelkviwsKPYLTEAPHLIVVMKQahlind----------------------------sneltSAHYNQISLGITVGI 234 Acanthocheilone...
XP_019860294  87 dlkfvnmnheKPYLEEASYLINLFKSqyhvnepeveqprvynplllllyyvsihlnaqiailkdlSVSYCFRVLLTIKKS 166 Amphimedon quee...
Feature 1                    ####                     #               # #      
5KO7_A       158 LLAAIHQAGLVALTHTPSp-mNFLQKILQRPENERPFLLVPVGYPaegamvpDLQRKDKAAV 218 Haliscomenobacter hydrossis DSM 1100
XP_022100270 223 LLAAVHNAGLVTVTTTPMnagPRLRTLLERPISEKVLVLLPVGHPedgatvpDLQRKALQEI 284 crown-of-thorns starfish
XP_014153824 231 LLGAVQNAGLCSVTTTPMnagPKLRAVCGRPESEKVLVLLPVGYPrsdatvpDLHRKPLNDI 292 Sphaeroforma arctica JP610
XP_002768445 223 LICALHNAGLVTLTSTPMgaeSAIRNILNRPSNEKVYLLMPVGYPsedatvpKRTSANRRRA 284 Perkinsus marinus ATCC 50983
NP_498712    260 LLAAIQNVGLSTVVTSPLnagPDISRILRRPENESILLLLPLGYAsedvlvpDLKRKPVEHI 321 Caenorhabditis elegans
VDM40254     247 LVAAIHNAGLVTVTTTPLnsgHLIRELLNRPKNEKVLLLLPIGYPaegamvpDIKRKVVEEI 308 dog roundworm
GCF55272     240 LLAALQVCLQLKYELDQDe-gWRVTCTSVFQKVTSTCFNYATDYG-------PGHTGQAGEV 293 Paroedura picta
XP_024499781 340 FITALHNAGLCTVPICVTnssRRIKKILNRPPNEEVLLVLPIGYPadqalvpDIKRKRLEDI 401 Strongyloides ratti
VBB27392     235 LIAALQDAGLATSITYPLygsEKIRKHLKRPSNEEVFLLLPVGFPaknatvpDLKRKSVEEI 296 Acanthocheilonema viteae
XP_019860294 167 LHFCSIWKEKCSVTTTPLnagGQIRELLGQLSNEKVMLVLPVGYPsevatvpDVKRKEFDIN 228 Amphimedon queenslandica

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