Conserved Protein Domain Family
PIPKc_PIP5KL1
?
cd17304: PIPKc_PIP5KL1 
Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PIP5KL1) and similar proteins
PIP5KL1 (EC 2.7.1.68), also known as PI(4)P 5-kinase-like protein 1, or PtdIns(4)P-5-kinase-like protein 1, may act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment, and conversion to PI(3,4,5)P3.
Links
?
Statistics
?
PSSM-Id: 340441
Aligned: 10 rows
Threshold Bit Score: 474.154
Created: 8-Mar-2017
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
catalytic coreATP binding
Feature 1: catalytic core residues [active site], 3 residue positions
Conserved feature residue pattern:K D DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Lys proposed to bind the alpha-phosphate of ATP; mutation of this residue in PIPKI-alpha and PIPKII-alpha destroys enzyme activity.
  • Comment:1st Asp functions as a weak base
  • Comment:2nd Asp binds catalytic Mg2+ or Mn2+
  • Citation:PMID 9753329
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
Q5T9C9         50 HELHGMTCMMQAGLWAATQVSMdhpptgpPSRDDFSEVLTQv---------hEGFELGTLAGPAFAWLRRSLGLaEEDYQ 120  human
XP_002935545  102 HEFYPLTCDLKQGLKQAIQESIhsdttiaLADEGYSAKITQg---------hEGFVMRTYAGPVFSHFRQSLGIsEESFT 172  western clawe...
XP_007898462   48 HEFYYFTCVMKEGLAAAVQISIdnpnlstLSDPDFKAVLTQv---------hKGFEMQTYAASVFAQFRQTLGMtEKEYQ 118  elephant shark
KPP65829       37 HEFYSLTCMMREGLSTAIQSTIdqplpneLCEEDFRMDITQi---------hKGFQMQTFAGPVFAWLRRSLGMeEKEYQ 107  Asian bonytongue
EMP38108      523 HEFYDLTCMLKVGLRAAIQEAIdnppadaLSDADCKAVLKQa---------hEGFEMRTYGGPAFAYFRHLLGMsEKEYQ 593  green sea turtle
XP_002127848   32 HPKYLFTQYIRTCLRSFLTNHPnkk--ivLTDEDYVEIVSQhle------vtIPICFTTFAPAVFYSIRKKIGLsSEEYL 103  vase tunicate
XP_013081382   97 HPHHQLVSCVRQGIRELNRKFPavgpkvgLNNLDFTEVLKTeiq-----snkKIFEFESYSPSVFATIRQAIDItENEFL 171  Biomphalaria ...
XP_003728024   71 HHLHSLASAIKKGFQSTRKNPQletdeesLESDDYGEVDEHlipm---enknKEAVFRYYAPNVFRDLRSLLNIsCQEFY 147  purple sea ur...
XP_005993325   33 HEFYEFTCMLKEGLTAAVQDSMdtleknsLSEADYTAKLTQt---------hKGFEMRTYAAPVFTHFRQIVGVsEKEYQ 103  coelacanth
XP_019640792   51 HRRWTLTNCVRIGLEKALADRThvkpieeLTKDDYEDIRCKrhtetidkksqQSFEFATYAGEVFATLRNIINIsEDEYL 130  Belcher's lan...

Feature 1                                           #                                             
Q5T9C9        121 AALGp--gGPYLQFLSTSKSKASFFLSHDqRFFLKTQgRREVQALLAHLPRYVQHLQRHPHsLLARLLGVHSLRVd-rGK 197  human
XP_002935545  173 KSLSc--nEFYLQFISNSKSKADFFLTNDkRFFLKTQtKREAHFMLQILRRYIEHFQLYPHsLLVKILGVYSITYa-qNK 249  western clawe...
XP_007898462  119 HSLAs--eGCYLQFISNSKSKANFFLTNDkRVFLKTQkKREIKFLLSKLKSYIQHIQNYPHsLLVKFLGVHSVSLp-qGR 195  elephant shark
KPP65829      108 HSLAs--qGGYLQFISNSKSKANFFLTNDkRFFLKTQnKREVRFLLANLRVYTKHLESYPHsLLVKFLGVHRIKIp-hER 184  Asian bonytongue
EMP38108      594 LSLSs--gSSYLQFISNSKSKADFFLTNNkCFFLKTQsKREIRFLLSNLPKYIQHLERYPHsLLVKFLGVHSIIVa-qEK 670  green sea turtle
XP_002127848  104 KVVSpgkdELYLEFLSNSKSGQNFFLTNNkQFMIKTItKTEANFFMKILKKYTNHFEEYPHsLLVKFVGLHSIKIkklSK 183  vase tunicate
XP_013081382  172 NSVAtvddHPYYEFISNSKSGQDFFLSNNmQFMFKSNrQRDVKFFISILRNYLQHFISYPHsLLVKYVGCYAIKFp-gKP 250  Biomphalaria ...
XP_003728024  148 DRLDk---EPYIQYKSNSRSGQIFFMTNDkRYFLKTEnRRDAKVLLHMLPDYVTHLTNYPHsLLVRIHGLYFIKLp-gKK 223  purple sea ur...
XP_005993325  104 LSLSs--kGFYLQFISNSKSKANFFLTNDkRFFLKTQsKREIRFLLSNLKVYIQHLEKYPHsLLVKFLGVHRIQIp-rQG 180  coelacanth
XP_019640792  131 NSVTpmanRRYLEFISNSKSGQDFFLTPDkRFMIKTQtKKETYFFLEHLRTYVEHFKKYPHtLMVKFLGLHNIKLk-gKK 209  Belcher's lan...

Feature 1                                                                                         
Q5T9C9        198 KTYFIVMQSVFYPaGRISERYDIKGCEVSRWVDPAPEGSpLVLVLKDLNFQGKTInlgpQRSWFLRQMELDTTFLRELNv 277  human
XP_002935545  250 KKYFIIMQSVFFPdERITSRYDIKGCKVSRWTEPEPEGSrVLQVFKDCNFEGNVIcldqQRAWLLLQMELDASFLQQLNv 329  western clawe...
XP_007898462  196 KKYFIIMQSVFYPdERIVARYDIKGCQVSRWTDPSPEGSqIIVVLKDLNFKGNMIgldqQRSWFIRQIEIDTEFLKGWNv 275  elephant shark
KPP65829      185 EKYFIVMQSVFYPdERINARYDIKGCEVSRWTDPAPEKSqLIVVLKDMNFEGKFItldhQRSWLLRQVEIDTSFLRRLNv 264  Asian bonytongue
EMP38108      671 KKYFIIMQSVFYPdERILERYDIKGCQVNRWTEPAPGGSqVIVVLKDLNFEGNSIhlgqQRSWLLCQMQVDTQFLKELNv 750  green sea turtle
XP_002127848  184 PVYFVVMLSIFYPgERIRARYDIKGCLIGRYTDPPPEGSnAVVILKEKNLEGKSVklgeQRTWFLTQIEIDTKFLQDIEv 263  vase tunicate
XP_013081382  251 KKYFLVMQSIFYPsDRIEERFDIKGCTAGRYQKPNAEGSqIIIVLKDQNFLTEVLdfgdQNQWFLQQIQADSEFLCGLNc 330  Biomphalaria ...
XP_003728024  224 GKFFSVMQSVFPP-EEGNNRYDLKGCVLNRYVKPEKEGSqYVTVLKDVNFGDQKLyirdQRQWFLRQVDLDVEFLKGFNi 302  purple sea ur...
XP_005993325  181 TKYFIVMQSVFYPdERINTRYDIKGCEVSRWTDPAPEGSqVIVVLKDLNFEGNSIsldqQRSWFMHQVQIDTQFLQGLHv 260  coelacanth
XP_019640792  210 RLYFIVMQSIFYPdERIRERYDIKACQASRYVLPEKDGSqIITVLKDNNFGDNKInlgsNRAWFLQQVQADTELLEELGv 289  Belcher's lan...

Feature 1          #                                                                              
Q5T9C9        278 LDYSLLIAFQRLHEDErgpgsslifrtars-------------------------------------------------- 307  human
XP_002935545  330 IDYSLLVGFQPLHADEknqswslanlivrtkrsvngaasptasntasvpgtvageedts--------------------- 388  western clawe...
XP_007898462  276 IDYSLLVAFQPLHPDErrlsssfaniilrtkksmitggspttstrapipglveeassvl--------------------- 334  elephant shark
KPP65829      265 LDYSLLLAHQPLHHDErgrthsfatlimrakksvyagsaptdsdpptfpgtaledgaa---------------------- 322  Asian bonytongue
EMP38108      751 LDYSLLVAFQALHADEkgrnlsfadiifrttkslsnpesslltsmsgimdeesdivv----------------------- 807  green sea turtle
XP_002127848  264 LDYSLLVGVQPLQNDEisrsrklstvisraqksvskshsispplhptlvdplqdeehlpgmvetnttt------------ 331  vase tunicate
XP_013081382  331 MDYSLLIGRQRKHTDEkvtehvativerigksispirkgmltsngdalyngqgdytn----------------------- 387  Biomphalaria ...
XP_003728024  303 MDYSLLIEQRAIHSIErendgeladlvirvkkstrgimrtkptvdvsknsqrpssmtgsnagssimdgaidlpgtvssae 382  purple sea ur...
XP_005993325  261 LDYSLLVALQPLHADErgqrwsfaniilrtkksinpggsptfstrttvpgiveeesavlv-------------------- 320  coelacanth
XP_019640792  290 LDYSLLVGITELHSDEknsqdlaslvqrvtkslhhgspeksannpksagstlheeishsaatl----------------- 352  Belcher's lan...

Feature 1                                                                                         
Q5T9C9        308 -----------------------------------------------------vqgaqspeesraqNRRLLPDAPNALHI 334  human
XP_002935545  389 ------------------------erdqggtglmgsqemtpanhipmkklkaqlsivsdtsdiiaqNRRLLPNYKNALHV 444  western clawe...
XP_007898462  335 -----------------------emerdaelgqskevpphsrseipleklmpggsselevpevaaqNRRLLPGYKNPLHV 391  elephant shark
KPP65829      323 -------------------------llaeetnalstegeepipleelhsrppggtvdldlqefkaqNRRLLPNFKNPLHV 377  Asian bonytongue
EMP38108      808 --------------------------semvgevdlyrlrelnsgvqdvsfqssakpdhdlayilaqNRRLLPRCRSPLHL 861  green sea turtle
XP_002127848  332 --------------npnppspqcscdcqvspslnlqrdetpgspltpphamyctrdvigpeeslkqNRRLLPDYRNELHV 397  vase tunicate
XP_013081382  388 --------------------------ralndlkestfqdiitlpeykpgvmfprsltdgvenfhkeHRRLLPKSKNALHI 441  Biomphalaria ...
XP_003728024  383 gqtldvdlthrsdvnhradfqyntnvkgsqemsedlgdfelgrvhrdsykttsgegasskttlqehNQRLLPNVHNAIHV 462  purple sea ur...
XP_005993325  321 -----------------------seticgtevcrvqevpadgvhiplqtmssqtsaeldlteiavqNRRLLPNYKNPLHV 377  coelacanth
XP_019640792  353 --------------------pvngvmgslpgmvdsvdepppdpnagteretdpgaknnmipnipglNRRLLPNTPNSLHI 412  Belcher's lan...

Feature 1                      #                                            
Q5T9C9        335 LDGpEQRYFLGVVDLATvYGLRKRLEHLWKTLRYPGrtFSTVSPARYARRLCQWVEAH 392  human
XP_002935545  445 VDGpEQRYFIGIIDIFTvYGLRKRLEHLWKSVRYRGqeFSTVSPLYYSRRICHWVESH 502  western clawed frog
XP_007898462  392 IDGtEFRYFVGIVDMFTvYGFRKKIEYLWKCIRHRGqsFSTVNPDKYARRLCQWVDGH 449  elephant shark
KPP65829      378 IDGpELRYFVGIIDIFTvYGFRKRVEHVWKRLRYPGktFSTVSPSAYARRLCRWVENH 435  Asian bonytongue
EMP38108      862 LDGpELRYFMGIIDLFTvYSFPKRLEHLWKCIRYRGqtFSTVSPSDYARRLCQWVESH 919  green sea turtle
XP_002127848  398 VDG-EERYYVGIIDFFTrFTLKKRLENAYKKLIYPPlsFSTVHPDVFAKRFRKYWEDH 454  vase tunicate
XP_013081382  442 LDGeEYRYFVGVVDFLTrFDWRQKTAQYWKIVKYSCgdHSTKSPKVYSRRFINFLRDH 499  Biomphalaria glabrata
XP_003728024  463 VDGeKDRYFVGVIDILTqYNWKKRMETMLKSCIAPRtpFSSVSSEKYAKRFNDYVAAH 520  purple sea urchin
XP_005993325  378 IDGpEMRYFVGIIDIFTvYGFRKKLEYLWKSLRYRGraFSTVNPAKYASRLCQWVQDH 435  coelacanth
XP_019640792  413 VDGeEYRYFLGIIDFFVtYGLKKKLENLWKKIRFPGqsFSTVPPEEYAERFRKYMAEH 470  Belcher's lancelet

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap