Conserved Protein Domain Family
metallo-dependent_hydrolases

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cl00281: metallo-dependent_hydrolases Superfamily (this model, PSSM-Id:412281 is obsolete and has been replaced by 469705)
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Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The family includes urease alpha, adenosine deaminase, phosphotriesterase dihydroorotases, allantoinases, hydantoinases, AMP-, adenine and cytosine deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolases, formylmethanofuran dehydrogenases and others.
Statistics
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Accession: cl00281
PSSM Id: 412281
Name: metallo-dependent_hydrolases
Created: 8-Feb-2008
Updated: 24-Nov-2020
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