3OLR,3BRH,4J51


Conserved Protein Domain Family
PTPc-N22
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cd14602: PTPc-N22 
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catalytic domain of tyrosine-protein phosphatase non-receptor type 22
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22), also called lymphoid phosphatase (LyP), PEST-domain phosphatase (PEP), or hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN22 is expressed in hematopoietic cells and it functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signaling through the direct dephosphorylation of Src family kinases (Lck and Fyn), ITAMs of the TCRz/CD3 complex, and other signaling molecules. Mutations in the PTPN22 gene are associated with multiple connective tissue and autoimmune diseases including type 1 diabetes mellitus, rheumatoid arthritis, and systemic lupus erythematosus. PTPN22 contains an N-terminal catalytic PTP domain and four proline-rich regions at the C-terminus.
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Statistics
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PSSM-Id: 350450
Aligned: 8 rows
Threshold Bit Score: 493.974
Created: 14-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 13 residue positions
Conserved feature residue pattern:x x x x x C x x x x R x xClick to see conserved feature residue pattern help
Evidence:
  • Structure:3OLR: Human PTPN22 binds consensus phosphotyrosine peptide 1; contacts at 4A
    - View structure with Cn3D
  • Structure:3BRH: Human PTPN22 binds mono-phosphorylated Lck active site peptide; contacts at 4A
    - View structure with Cn3D
  • Structure:4J51: Human PTPN22 binds inhibitor L75n04; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #####                                                                         
3OLR_A        76 KNRYKDILPYDysrvELSLITSDEDssYINANFIKGvygPKAYIATQGPlsttllDFWRMIWEYsvLIIVMACMEYEMGK 155 human
XP_001235234  57 RNRYKDILPYDhsrvELSLITSDTDshYINANFIKGvygPRAYIATQGPlpttvtDFWRMIWEYevLIVVMACMEFEMGK 136 chicken
3BRH_A        57 KNRYKDILPYDysrvELSLITSDEDssYINANFIKGvygPKAYIATQGPlsttllDFWRMIWEYsvLIIVMACMEYEMGK 136 human
4J51_A        80 KNRYKDILPYDysrvELSLITSDEDssYINANFIKGvygPKAYIATQGPlsttllDFWRMIWEYsvLIIVMACMEYEMGK 159 human
XP_017947309  57 KNRYKDILPFEhsrvELSLITSDEDtdYINANFIKGvyyPRAYIATQGPlpntlvDFWRMIWEYkiEVVVIACMEFEMGK 136 tropical clawed...
Q9Y2R2        57 KNRYKDILPYDysrvELSLITSDEDssYINANFIKGvygPKAYIATQGPlsttllDFWRMIWEYsvLIIVMACMEYEMGK 136 human
XP_005987751  58 KNRYKDILPYDhcrvELSFITSDTDsdYVNANFIKGvygPRAYIATQGPmsctvtDFWRMIWEYniQIIIMACREFEMGR 137 coelacanth
XP_007897585  58 KNRYKDIVPFDhsrvKLSLIISDNDsdYINGNFIKGvygPQAYIATQGPlphtvmDFWRMLWEYnvSIVIMACREFEMGR 137 elephant shark

Feature 1                                                                                        
3OLR_A       156 KKCERYWAepgemqlefgPFSVSCEAEKRKsdYIIRTLKVKfnsetRTIYQFHYKNWPDHDVPssIDPILELIWDVRCYQ 235 human
XP_001235234 137 KKCERYWAevgdsalqcgPFSITCEAEEKKneYVIRTLKVSlneavRTIHQFHYQNWPDHDIPssIDPILELIGEVRCYQ 216 chicken
3BRH_A       137 KKCERYWAepgemqlefgPFSVSCEAEKRKsdYIIRTLKVKfnsetRTIYQFHYKNWPAHDVPssIDPILELIWDVRCYQ 216 human
4J51_A       160 KKCERYWAepgemqlefgPFSVSCEAEKRKsdYIIRTLKVKfnsetRTIYQFHYKNWPDHDVPssIDPILELIWDVRCYQ 239 human
XP_017947309 137 KKCERYWVelgsealqcgPFSITCCNEMKKteYTIRVLKAAygkenRIIYQFHYKKWPDHDVPssVEHILDFINDFRQIQ 216 tropical clawed...
Q9Y2R2       137 KKCERYWAepgemqlefgPFSVSCEAEKRKsdYIIRTLKVKfnsetRTIYQFHYKNWPDHDVPssIDPILELIWDVRCYQ 216 human
XP_005987751 138 KKCERYWAnlgeepflskPFSIVCDTEENKgdYIVRTLRATclnesHTVYQFQYTQWPDHDVPtsVDPVLEMISEIRSYQ 217 coelacanth
XP_007897585 138 KKCERYWAysgedpchygPFSVTCEKETNKseYIVRILKVQfqsmcRTVHQLHYMNWADHDVPssIDPILDMITDMRLLQ 217 elephant shark

Feature 1                  ### ###                                        ##               
3OLR_A       236 EDdsvPICIHSSAGCGRTGVICAIDYTWMLLKdgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF 309 human
XP_001235234 217 PDdsiPICIHCSAGCGRTGVVCAIDYTWKLLKdgivPVNFSIFSLIQEMRTQRPSIVQTKEQYKLVYNAVIELF 290 chicken
3BRH_A       217 EDdsvPICIHSSAGCGRTGVICAIDYTWMLLKdgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF 290 human
4J51_A       240 EDdsvPICIHCSAGCGRTGVICAIDYTWMLLKdgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF 313 human
XP_017947309 217 KDdspPICVHCSAGCGRTGVICAIDYIWRLLKdkiiPMNFSIYSIIQEMRTMRSSLVQTKEQYELVYNAVINLF 290 tropical clawed frog
Q9Y2R2       217 EDdsvPICIHCSAGCGRTGVICAIDYTWMLLKdgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF 290 human
XP_005987751 218 AHeevPICVHCSAGCGRTGVICAIDYTWNLLKdgivPECYSIYNLIQEMRTQRPLVVQTKEQYEFVYTAVIKLF 291 coelacanth
XP_007897585 218 HHddiPICIHCSAGCGRTGVICAIDYTWKLLKdgiiPENFHVYNLIQEMRTQRPSIVQTKEQYELVYSAITYLF 291 elephant shark

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