The eukaryotic RPB11 subunit of RNA polymerase (RNAP) II is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III. RNAP II is responsible for the synthesis of mRNA precursor. The RPB11 subunit heterodimerizes with the RPB3 subunit, and together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, and stabilizes their association.
Comment:The yeast RNAP II RPB11/RPB3 heterodimer, together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, stabilizing their association.
Structure:1I50_K; Saccharomyces cerevisiae RNAP II RPB11 subunit heterodimerizes with RPB3 subunit (1I50_C), defined using 3.5A contacts - View structure with Cn3D
Comment:RPB11 interfaces with the RPB11-like subdomain of RPB3.
Jiyao W et al.(2023). "The conserved domain database in 2023.",