6MHQ,3IZ1


Conserved Protein Domain Family
Connexin

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pfam00029: Connexin (this model, PSSM-Id:394986 is obsolete and has been replaced by 459638)
Connexin
Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.
Statistics
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PSSM-Id: 394986
Aligned: 193 rows
Threshold Bit Score: 159.217
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6MHQ_A          3 DWSFLGRLLE-NAQEHSTVIG----KVWLTVLFIF--RILVLGAAAEEVWGDEQSDFT-CNTQQPGCENVC-YDRAFPIS 73 
32_pfamImport   1 KLGFLSSVLC-KWHAQATVIG----KSLLPVLLLI--RFVILGAAVQTVWLNDEGKFQ-CNTQRPGCEVTC-FDAVTPLS 71 
XP_007261065    3 EWTILERLLEaAVQQHSTMIG----RILLTVVVIF--RILIVGIVGEKVYEDEQIMFI-CNTLQPGCNQAC-YDKAFPIS 74  Mexican tetra
XP_004076540    3 EWTILERLLEaAVQQHSTMIG----RILLTVVVIF--RILIVGIVGEKVYEDEQIMFI-CNTMQPGCNQAC-YDKAFPIS 74  Japanese medaka
28_pfamImport   1 EWTILERLLEaAVQQHSTMIGsffeKVCMSVLAVErmRFQRAVNSDVSPW---QESLPcIKTLEHGCIQICgSDCSFPIC 77 
XP_006628734   42 EWTLLKRLLD-AVHQHSTMIG----RLWLTVMVVF--RLLIVAVATEDVYTDEQEMFV-CNTIQPGCSNIC-YDSFAPIS 112 spotted gar
Q4T8N8          3 EWTLLKRLLD-AVHQHSTMIG----RLWLTVMVIF--RLLVVAVATEDVYTDEQEMFV-CNTLQPGCSTVC-YDAFAPIS 73  spotted green ...
XP_026691633      --------------------------------------------------------------------------------     vase tunicate
XP_031594188    3 EWTLLKRLLD-AVHQHSTMIG----RLWLTVMVIF--RLLIVAVATEDVYTDEQEMFV-CNTLQPGCSTVC-YDAFAPIS 73  Oreochromis au...
XP_025759016  199 EESVLSRLLA-LWHSHAGFLG----KTVLPVLQLV--RIVLVGAAVQPVW--SNDYFV-CDTNQPGCSSAA-YNAVFPFS 267 Nile tilapia
6MHQ_A         74 -HVRFWVLQIIFVSTPTLIYLGHVLHLVRMEEK-RK----------------ER-------------------------- 109
32_pfamImport  72 -LPRLWTLQLVLVLAPGLVFLCYLIHLTNQETQ-LN----------------SK-------------------------- 107
XP_007261065   75 -HIRYWVFQIILVCTPSLCFITYSVHQSAKQKD-RQ----------------Yt-------------------------- 110 Mexican tetra
XP_004076540   75 -HIRYWVFQIILVCTPSLCFITYSVHQSAKARD-RS----------------Ysllhhy--------------------- 115 Japanese medaka
28_pfamImport  78 pNVQYWLFQIILVCTPSLCFITYSVHQSAKARD-RS----------------YSllhpymd------------------- 121
XP_006628734  113 -QPRFWVFQIITVSTPSLCFIIYTWHSLSKQPEgER----------------VT-------------------------- 149 spotted gar
Q4T8N8         74 -QPRFWVFHIISVSTPSLCFIIYTWHNLSKVHS-AA----------------QRhprgagqplgqdvgqaakevlgkeag 135 spotted green ...
XP_026691633      --------------------------------------------------------------------------------     vase tunicate
XP_031594188   74 -QPRFWVFHIISVSTPSLCFIIYTWHNLSKHNA-TQrlgqgagdapgqggrdGGr------------------------- 126 Oreochromis au...
XP_025759016  268 -VHQYWTLQVVFVLAPGLIYFSYLVHLLVTQK------------------------------------------------ 298 Nile tilapia
6MHQ_A        110 --------EEEPPKAAGPAEEHQD----PAPVRDDRGKVRI-------------------------------AGALLRT- 145
32_pfamImport 108 --------IEKKYERNTHSDLFVC----LSMKTVLHQSETGtv----------------------------iKRQSLWA- 146
XP_007261065  111 -------fLHGPYIDHGHGPSRKL----RNLNGILVHPDSKdehecletkeipnap-rglthastksaktrrQEGISRF- 177 Mexican tetra
XP_004076540  116 ---vdhhgHGHHGRHGHDHHGRKL----HARNINGILVHPEsskddhdmdvkeipngprglpgthknakvrrQEGLSRF- 187 Japanese medaka
28_pfamImport 122 --shghggHHGRHHDHHARKLHSRningILVHPDSSKEDHDclevkeipngprg------lpqthknakvrrQEGISRF- 192
XP_006628734  150 --------ESKEACERSCDSDSCSvkshRHLGHSLADILEGtdvhvksgrvsk--------trlkvvkkggkKSGILSKy 213 spotted gar
Q4T8N8        136 kaggdrevYPPSCSSDSCSVLSHK----HLGHSLVDILDGVaarslrngdpatsrpiqaytfkdgsseglavSGGVLSKc 211 spotted green ...
XP_026691633    1 ----------------------mnrylgVRTANKRWKVLTNhvips---------------------elhktRGQCIWRl 37  vase tunicate
XP_031594188  127 -------eAYDRSCDSDSCSIQSH----KHLGHSLANV--Eggae-----------------------ahagSGGVLSKc 170 Oreochromis au...
XP_025759016  299 ------------------------------------QSETGtv----------------------------iKRQSLWA- 313 Nile tilapia
6MHQ_A        146 YVFNIIFKTLFEVGFIAGQYFLY--GFQLKPLYRCDRWPCPNTVDCFISRPTEKTIFILFMLAVACVSLLLNVLEIYHLG 223
32_pfamImport 147 YLGFLSAVVLLEVGFAVGQCLKF--GLFLPPMFNVAVSPCPHTVDCFLPQPNEKSVFMFIMLVLACLSGLLTLVEMLSMY 224
XP_007261065  178 YVIQVVFRNALEIGFLAGQYFLY--GFNVPAMFECDRYPCVKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLG 255 Mexican tetra
XP_004076540  188 YVIQVVFRNALEIGFLAGQYFLY--GFNVPGMFECDRYPCVKEVECYVSRPTEKTVFLVFMFAVSGICVLLNLAELNHIG 265 Japanese medaka
28_pfamImport 193 YVIQVVFRNALEIGFLAGQYFLY--GFNVPGMFECDRYPCVKEVECYVSRPTEKTVFLVFMFAVSGVCVLLNLAELNHLG 270
XP_006628734  214 YVFHVFFRATLEIGFVFAQWVLF--GFKVPSHFVCMSYPCTQRVDCYVSRPTEKTIFLIFMFSVGVFCICLNFLELNHLG 291 spotted gar
Q4T8N8        212 YIFHVCLRAALEVGFVAAQWKLF--GLQVPVRFLCTSSPCNQPVDCYVSRPTEKTIFLIFMFCVGVFCIFLNLLELNHLG 289 spotted green ...
XP_026691633   38 YLLQIFSRMLIECVFIMLQYTVYfyRWTVPQVFRCQVWPCPHTVDCFISRPQEKTVFFRYMYVISAFSILLSIGELLYIG 117 vase tunicate
XP_031594188  171 YIFHVCLRAVLEVGFVLAQWKLF--GFQVPVHFLCTSSPCSQPVDCYVSRPTEKTIFLLFMFCVGVFCILLNLLELNHLG 248 Oreochromis au...
XP_025759016  314 YLGFLSAVVLLELGFAVGQCLKF--GLFLPPMFNVAVSPCPHTVDCFLSQPNEKSVFMFIMLVLACLSGLLTLVEMctvm 391 Nile tilapia
6MHQ_A        224 W 224
32_pfamImport 225 L 225
XP_007261065  256 W 256 Mexican tetra
XP_004076540  266 W 266 Japanese medaka
28_pfamImport 271 W 271
XP_006628734  292 W 292 spotted gar
Q4T8N8        290 W 290 spotted green pufferfish
XP_026691633  118 W 118 vase tunicate
XP_031594188  249 W 249 Oreochromis aureus
XP_025759016  392 k 392 Nile tilapia
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