Conserved Protein Domain Family
MPP_superfamily

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cl13995: MPP_superfamily Superfamily (this model, PSSM-Id:417454 is obsolete and has been replaced by 472684)
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metallophosphatase superfamily, metallophosphatase domain
Metallophosphatases (MPPs), also known as metallophosphoesterases, phosphodiesterases (PDEs), binuclear metallophosphoesterases, and dimetal-containing phosphoesterases (DMPs), represent a diverse superfamily of enzymes with a conserved domain containing an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. This superfamily includes: the phosphoprotein phosphatases (PPPs), Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.
Links
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Taxonomy: root
PubMed: 215 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl13995
PSSM Id: 417454
Name: MPP_superfamily
Created: 16-Mar-2010
Updated: 24-Nov-2020
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