6BBG


Conserved Protein Domain Family
Orai-1
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pfam07856: Orai-1 (this model, PSSM-Id:400282 is obsolete and has been replaced by 462291)
Mediator of CRAC channel activity
ORAI-1 is a protein homolog of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins.
Links
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Statistics
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PSSM-Id: 400282
Aligned: 30 rows
Threshold Bit Score: 102.713
Created: 20-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6BBG_A           14 LSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLd----hDTN-VPPGMLIAFAICTTLLVAVHMLALMISTCILPNI 88  fruit fly
XP_002970256     86 KNRRDVEEKSEQLKAISNLAALFAGFAVVTLTQFTIap------dpVLTVWIAFYGVLTAIAVGLMTISMVTCTLILGSI 159 Selaginella ...
EFJ26564         27 LNRRDVEEKSEHLRSLSWITGLVTSFTMTAPVEFNTpk-------sIRAGRLMPYAICTAIVPTLMTTSTIICVYLLGCI 99  Selaginella ...
jgi:OSTLU_33356  96 KNRRDVEEKGEQLRTTSNLSALISGFAVVALVELQFsdptvkAF--QSEALIAAYAGATAVTVALMLNAMVLCSFMLSNI 173 Ostreococcus...
XP_002506166     94 KNRRDVEEKSEQLKSISNLSALIGGFAVVAFVELQFsdpnetPE--RNEGLIVAYAATTALVVALMLNSMVLCSFMLCSI 171 Micromonas c...
EEH58374         93 KNRRDVEEKSEQLKSISNLSALIGGFAVVAFVELQFhdpetrPS--QSEALITAYAATTALTVGLMLNSMVLCSFMLCSI 170 Micromonas p...
EDP09286         81 RNRTEVMEKTEQLKAVSSLSALLAGFALVGFLEFQFvvs-----enYNKALLPLFALTTSITVGVEVAAVVLTSLMLANI 155 Chlamydomona...
EED95370         38 DARRAVDEKAQQLKVLANQSALVAGFSMVVLVESNIpp-------dINGALLTLFGGVTACVIALMLVSTLNATYMLVAI 110 Thalassiosir...
XP_004993864      6 arRRQLALFTHKLEQTGGTSALLSGFALVAMVELNLpegrthVEEfDNNPVFYIFSAVTSVLIALHLFALMVSTSVLPYL 85  Salpingoeca ...
OZF95390        103 SEKYNYDLSKAQLKASSRTSALLAGFAMVCLVELQYde-------kTSKPLLIVLGVVTSLLVSVHLLALMMSTCILPYM 175 Caenorhabdit...

6BBG_A           89 ETVSNLHSIS--LVH------------------ESPH-----------------------------ERLHWYI----ETA 115 fruit fly
XP_002970256    160 LKNGKSYVNEeaEEEfmfkcrdfvksyrtgdkpPSPR-----------------------------RTFEAFWeircEDD 210 Selaginella ...
EFJ26564        100 LRMGKSFVSEhaEEEfmalchsyaesaapsqppPVPS-----------------------------RTFQNFWaarcKDY 150 Selaginella ...
jgi:OSTLU_33356 174 LRNGKSYVSEdeEAEflyacrkfalsyapgdtpPQPQ-----------------------------RSFERYWetrcEAD 224 Ostreococcus...
XP_002506166    172 LRNGKTYVSDeeEADylfrcrrfahefklgdapPRPH-----------------------------RSFERHWetrcEDD 222 Micromonas c...
EEH58374        171 LRNGKTYVSEdeEAEylyrcrrfaleftsgdkpPLPK-----------------------------RSFERHWetrcEDD 221 Micromonas p...
EDP09286        156 LRTAKSYVNEqeEAEfmhrcqafmanyrpgdrpPAPV-----------------------------RTFAVHWarrcEHE 206 Chlamydomona...
EED95370        111 LRYdcv-------------------------nrEVP--------------------------------FDEFWrkrcEPD 133 Thalassiosir...
XP_004993864     86 KSA--IEDIDhhLAQralta---------rakgQALHnligpqdtlfddttdtshdngllervkhlDQFSSYI----SKA 150 Salpingoeca ...
OZF95390        176 EATGCTQ--------------------------DSPH-----------------------------LKLKFYI----DLS 196 Caenorhabdit...

6BBG_A          116 WAFSTLL---G------LILFLLEIAILCWVKFYDLSPp--AAWSATVVLIPVMIIFMAFAIHFYRSLVSHKYE 178 fruit fly
XP_002970256    211 WKRAFQFfawGrplnsrVLSFLFSLIPIGWIKFY--NSr-lTAGLFMGVIAVSIIVWG-FVQYLWGGYLTKTfr 280 Selaginella moelle...
EFJ26564        151 WNTAFSLffwG------VSFFLALLCTMGFIKF---SDd-rVALSFTTVIGISFVAWL-GIQVKWGYYLKKEYE 213 Selaginella moelle...
jgi:OSTLU_33356 225 WRKAFRMftyG------VPMFLTTLTLSAWLKFW--YSt-vTCSIVTGVAAVAIGLWW-RTQSAWGWHLMKRSE 288 Ostreococcus lucim...
XP_002506166    223 WRHAFRMftcG------VPVFLVNVSCMSWLKFH--YSp-lASWTVTAIAAVASLGWL-HTQNNWGFHIAKSQA 286 Micromonas commoda
EEH58374        222 WRHAFRMftcG------VPVFMVNIACMAWLKFN--YSy-aAAGTATAVAVCATAGWA-RTQMNWGWHISRRYH 285 Micromonas pusilla...
EDP09286        207 WRIAFRLfstG------IPFFFVNLALAGWIKFHDAQTp-vAPIIVTLIMGFSLMYNV-YTHRKWGEYLMADGS 272 Chlamydomonas rein...
EED95370        134 WKMALRTfsyG------IPLFMVVVALVAWVSFWDHESlyySASVVTAISVMVLILWFGSTERKWGEFLRMSDA 201 Thalassiosira pseu...
XP_004993864    151 WFFANGV---G------IALFLLQLALISYIKFLAHTPg--AGWTGVGTLSPAFVLFMVFIYRFYRKIVGSQst 213 Salpingoeca rosetta
OZF95390        197 WLFSTCI---G------LLLFLVEIGVIFYVKFTAVGYp-tAGYITTAMLVPVGIVFVLFSYLIHKNRVSHSLG 260 Caenorhabditis rem...
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