Conserved Protein Domain Family
HAUS-augmin3
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pfam14932: HAUS-augmin3 (this model, PSSM-Id:405601 is obsolete and has been replaced by 464384)
HAUS augmin-like complex subunit 3
This domain is subunit three of the augmin complex found from Drosophila to humans. The HAUS-augmin complex is made up of eight subunits. The augmin complex interacts with gamma-TuRC, and attenuation of this interaction severely impairs spindle MT generation. Furthermore, we provide evidence that human augmin plays critical and non-redundant roles in the kinetochore-MT attachment and also central spindle formation during anaphase in human cells.The HAUS complex is required for mitotic spindle assembly and for maintenance of centrosome integrity.
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Statistics
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PSSM-Id: 405601
Aligned: 39 rows
Threshold Bit Score: 170.572
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_011485878         29 WLFDRsPENLHFLRFVCRTLNRSNVLSPEEVAAFQELQKSGKpILDEAALGEVLKIAG---PSGGSSaniigPLSSVvsp 105 Japanese...
XP_002074800         22 WILYD-EQFERFFNFISENITDANILTEQELLERDEMVLNGN-WLDKPECELALRRIDaenPGLLKHk---pQNVTAlss 96  Drosophi...
EDW32833             22 WLLYD-EKLEKFFKYLSVSITDSNILTEQEVLERDEMQHRAN-WLTGSELQLKQQEIEaenPGLLTHt---qQDVDAlsa 96  Drosophi...
WGS:AAPP:GF12731-PA  22 WILYD-EQLEKFFKFLSQDVTDANILTESQVLEREEMRRRNE-WLEESDRELKLLQIEsesPGLLKFn---rQDVSGltm 96  Drosophi...
Q9W2P0               22 WILYD-EQMEMFFKFLSGNITDANILTERQVLEREEMQRRGE-WLSASDRELKLLQIEaesPGLLNYk---qQDVDAltm 96  fruit fly
XP_002055549         23 WIVYD-EQFEKFFNFLSENVTDSNILTARELLERDEMMQRGE-WLQESERILKLQQIEsenPGLLKYt---nQDVETlaa 97  Drosophi...
WGS:AAPU:GI15999-PA  22 WIIYD-EQFEKFFNFLSENITDSNILTEREVLESEEMKQRGA-WLKESERVLKLQQIEsenPGLLKYt---aHDVDAlal 96  Drosophi...
EDW00518             22 WIIYD-ERFEKFFQFLFKNISDSNILTDHELLARDEMMQHGE-WLNETERQLKLQQIEaewPGLLEHt---dEDLEAlsa 96  Drosophi...
Q16G91               23 WLLHD-ESFKEFFDWFGKSVTEDNLASDSLLREYSDLERNDL-VLSEEEVQVELELLCkdfPNILEYn---dDDVEIyee 97  yellow f...
ETN61091             23 WVVHD-ENFRDFFDWFAK-VDDDNLITDALDKDYDELKRHDD-VYEESEVDALLKQLDtqySNILDYt---dRDVTEleq 96  Anophele...

XP_011485878        106 ftREkdlaVEDLEAELQELCREKGLKQRRYNKLQILAASQADVELKLTRELDSRTCKLNEAGASIRAENAETNTLLQKLT 185 Japanese...
XP_002074800         97 eiAVledaAHEYAVLIDDMQNSKRIITNNLNNLEYEITKLQNEGRGLIASSQTRAKQLEDLQRENCKLSIEAKKGFTSQQ 176 Drosophi...
EDW32833             97 vgAAiqeaSADYASLIENMANTKQTINNNLIELECAASALQNTEKILLSDCQEKAKQLEELQSENCKLSSEAKKAFISEP 176 Drosophi...
WGS:AAPP:GF12731-PA  97 eiASieeaSRDYALLLEDMLNAKHSITNHLSELECAACELQSKEKELLSECQSKAKQLEELQRENCRLSGEAKKSFTTPQ 176 Drosophi...
Q9W2P0               97 siEAiedaSRDYATLLEDMMTTKHSITKHLGEVECVTAELQLREKDLIAECQSKAKQLEELQQENCRLSAEAKKAFTAPQ 176 fruit fly
XP_002055549         98 avEVieeaTNDYSTLIDEMQNTKHSIISKLSELESTILLLHNTEREMLVECQAKARQLEELQRENCKLSEDTNKGFTLPQ 177 Drosophi...
WGS:AAPU:GI15999-PA  97 evEAikeaTKDYCILIDEMQNTKHSQSSKLSELECTILSLSNGERELLGECQAKARLLEEVQRENAKLSEEANKGFTMQQ 176 Drosophi...
EDW00518             97 eiEQlqqaTNDYNVLIDEMKNTKHSININLSELEYEIRPLQVAERELLGECQKKAGQLEQLQRHNRELVEETSREFTMQQ 176 Drosophi...
Q16G91               98 qlEElvaiEEQYEKLLADAKQTEKGLTKELSELDMQLMDAEFNQGKMATECMEKARFVEEIQSNSQQQIFDMHQCYVQAQ 177 yellow f...
ETN61091             97 qlEQmveiEEHYERLLEDAKKTDILLTKELTDIERATIDAQYLMEKQEKSCLTLGKRLEENQLITQQKIADLHHCYLQPQ 176 Anophele...

XP_011485878        186 DevsklasylpppsvkhegdplsqlnvssprtPTSLLSQLSLDPYLHQEERNTKNLAALTQKHFFsgISNIVETScsehf 265 Japanese...
XP_002074800        177 S-------------------------------PPVFMHQQPLEQYFLKNDSFVQYFNLYLKENFK--IQDNQDFQ----- 218 Drosophi...
EDW32833            177 M-------------------------------PQLFMHQLPLEHYFLKCDSFMQYFTLYIKENFK--IQKNNEF------ 217 Drosophi...
WGS:AAPP:GF12731-PA 177 M-------------------------------PPLFMHQLPLEQYFLKCDSFMQYFTLYVKENFK--IQEYDEF------ 217 Drosophi...
Q9W2P0              177 L-------------------------------PPLFMHQLPLEQYFHKCDSFMQYFTLYVKENFK--IQDYDEF------ 217 fruit fly
XP_002055549        178 V-------------------------------PPLFMHQMPLDQYFLKCDSFMQYFTLYMKENFK--IQELIDF------ 218 Drosophi...
WGS:AAPU:GI15999-PA 177 S-------------------------------PPLFMHQMPLEQYFLKCDSFMQYFTLYMKENFK--IQEFTEF------ 217 Drosophi...
EDW00518            177 M-------------------------------PPLFMHQLPLDQYFLKCDSFLQYFTLYMKDNFK--IQEYAEF------ 217 Drosophi...
Q16G91              178 N-------------------------------PPLFVYQMPIEQFNMKCDQFLKYLEMYIRKHFS--VRNLDDSE----- 219 yellow f...
ETN61091            177 N-------------------------------PPLFVYQMPIEQFDAKCDQFLKYLQMYVKKHFP--VRHLEGFK----- 218 Anophele...

XP_011485878        266 qvldlsscedgevkegNQDKVie-nrRTEMARLQWSHIVAQHQLMLAVAE 314 Japanese medaka
XP_002074800        219 ----------------NSLVDdmevaNSNLEVLQNSLEFYTIAIIKKKIK 252 Drosophila willistoni
EDW32833            218 ----------------STAEVnilheKEKLESLERGIQYYALAFIKKKAK 251 Drosophila persimilis
WGS:AAPP:GF12731-PA 218 ----------------QIAENdflheKHKLEDLQNGIQHYALSYIRHKAK 251 Drosophila ananassae
Q9W2P0              218 ----------------QSAEEdlgreKAKLEDLERGIQFYALSYIRTKAK 251 fruit fly
XP_002055549        219 ----------------ESAEVdvqhfNSKLENLQNSIQYYTLEYIKEKAK 252 Drosophila virilis
WGS:AAPU:GI15999-PA 218 ----------------EDAEVnmqhfNSNLENLQKSIQYHTLEYIKEKAK 251 Drosophila mojavensis
EDW00518            218 ----------------ESIDVdiqqmNSKLENLQNSMEYYTLAYIKKKAT 251 Drosophila grimshawi
Q16G91              220 ----------------HEPDQsqrdiIIQLESIKSRLDVEEGKLTDASKE 253 yellow fever mosquito
ETN61091            219 ----------------SSTELsnsevLDELEDIKLRLDVEELKLLEEKRE 252 Anopheles darlingi
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