Conserved Protein Domain Family
DPCD
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pfam14913: DPCD (this model, PSSM-Id:405583 is obsolete and has been replaced by 464369)
DPCD protein family
This protein is a found in eukaryotes and a mutation in this protein is thought to cause Primary Ciliary Dyskinesia (PCD). This protein is 203 amino acids in length, 23 kDa in size and its function remains unknown. The gene that encodes this protein is a candidate gene for PCD and is expressed during ciliogenesis. PCD affects the airways and reproductive organs, and probing Northern blots show DPCD expression in humans is highest in the testes. Additionally, there is no indication of major splice variants.
Links
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Statistics
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PSSM-Id: 405583
Aligned: 31 rows
Threshold Bit Score: 246.765
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001956075   6 WLNYLQSAEKNSMISGRLRKVLYKFPDGQQMAEEYNMDTGIIQRRAWRKCKQLMGEPEWEIELGEEPRQLNwsgnkqtgp 85  Drosophila anan...
EDV20765       4 WVEMLKSSQKTCLVQDGRKKIHYTFKNHTEMAEEYDMATFDLSVRKFRKKSTLGSSGQWEYEIGEATNITN--------- 74  Trichoplax adha...
EDO40351      11 WLETLRNARKTSLVQDGKRKIHFTFADGTQMVEEYSVANGELLVRKWKKKTTLGKECKWEYEIGEEVQPVN--------- 81  starlet sea ane...
Q0IEH0         6 WLTKIRGADKSSAIQGTVRKVHYSFPDGTEMAEEYSTETGCVLRRAWKLRSDLLRKDDWEIELGEPIPK----------- 74  yellow fever mo...
XP_002431095   6 WLTAISNSEKTCIIQD----VHFKFSDGQEMVEEYNLETNVVVRRAWKVTKKFGSQPKWEVEIGDPEPCFQ--------- 72  human body louse
XP_001607578  31 WLKLLQDAKKTAIIQDGKRKVHFLMTDGREMVEEYSVDTNVLVKRAWKEKGKLGQEIGWVVEVGDPEPNPA--------- 101 jewel wasp
EFN69346       6 WLKIIQNAKITVLIEDGKRKVHFLFENGKEMVEEYNMDTNVVVRRLWKKKNNFGTDIGWIVEIGEPEPK-E--------- 75  Florida carpent...
XP_012062541   6 WLKIIQNARKTAVIEDGKRKVHFLMEDGKEMVEEYSTDTNVVVRRAWKEKNGFGTNIGWMVEVGDPELK-Q--------- 75  Atta cephalotes
XP_004932676  37 WYHTLLDAEKSCLKEEKVKKIHYKFEDGREMVEEYNVDTQVLLRRAWKVKGKLGGEGKWHVEIGDPIPDAI--------- 107 domestic silkworm
EEZ97894       3 WLSQLKSAKKSCMVQNNLKKVHYDFGNGKEMVEEYNMDTNVVTRRAWKVKGEMGGEGEWDIELGDPEVNPT--------- 73  red flour beetle

XP_001956075  86 ggdADSlagSEFTVRESNTAPLLTKRVTKKNIEWRIRNMPYALEVYNVTASPEQRAIIVRTTNKKYYKVIPVPDLDRCGV 165 Drosophila anan...
EDV20765      75 ---I-----EELSIRESNTTPRFSAKYSKNAFQWRIRNLPYPLDNYSITVDDEKRQLVLRTKNKKYFKRISIPDMDRFHL 146 Trichoplax adha...
EDO40351      82 ---I-----DSEHIMESRANPIFIRKDVNKAFQWRVRNLPYPLEVYSVTVDDDRKTITTRTNNKKYFKKFSIPDMVRAEL 153 starlet sea ane...
Q0IEH0        75 ---ALKndhDGFALQEAATEPFLSKRVTRNCIEWRIRNLPYPLSTYTITCEGDARTITVRTSNKKYFKKIAVPEFQRCGF 151 yellow fever mo...
XP_002431095  73 ---EDM---ENSGIKESSTAPTTTARITKNCLEWRIRNLPYPIDNYTVLASQDDNCIIVKTKNKKFFKKIRVPDLERIGV 146 human body louse
XP_001607578 102 ---DNL---ESVGIRESSSNPIISRRTTKTALEWRIRNLSYPKDVYSVTAEDDG-TITVRTSNKKYFKKINVPDLERAGL 174 jewel wasp
EFN69346      76 ---NNI---EKDGIQESSNTPFVTQRITKTCLEWRIRNLPYPSNVYSVTAEEDN-TITVRTSNKKYFKKLKVLDLERIGL 148 Florida carpent...
XP_012062541  76 ---NNI---EIYGIEESSNTPIITRRITKASLEWRIRNLPYPESVYSITAEHDG-TMTVRTSNKKYFKKIKIPDLERIGL 148 Atta cephalotes
XP_004932676 108 ---SNS---DCAEITECKDQPQVFRRNTRINLEWRIRNLPYPIETYSISANNDERCIVIRTTNKKYFKKFKIPELERLNL 181 domestic silkworm
EEZ97894      74 ---Ke----QNLIIRENSGQPVVSRRNTRINLEWRIRNLPYPIETYSVTVDNEKNCLVVKTTNKKYYKILRVPELDRLRI 146 red flour beetle

XP_001956075 166 APAQDNISVHHQFNTLIITYKKPDILCEMEAQVLLLLKNVETETD 210 Drosophila ananassae
EDV20765     147 PLDQNAVKLAHANNCLIISYQKPSQIIEHEKALHKELRKMKASKD 191 Trichoplax adhaerens
EDO40351     154 PLDQSSISLAHANNTLIISYAKPPMILEQEKLIKVELAKTQGSKE 198 starlet sea anemone
Q0IEH0       152 APKVEDLMVKHQYNTLIIAYKKPAILVEMEKAVLAELQNVETVEY 196 yellow fever mosquito
XP_002431095 147 KLEQDKIDYSHKFNTLIISYKKPPQLILSEKLILEEVNKLKSVKE 191 human body louse
XP_001607578 175 KPEQDRISFTHQFNTLIITYKKPPKLLDMEKKVYEMVSQLKVSKD 219 jewel wasp
EFN69346     149 KPEQERISFKHQYNTLIITYKKPLELLNVEKKILSRILQFKPIES 193 Florida carpenter ant
XP_012062541 149 KPEQERISFRHQYNTLIITYKKPPQLLNMEKKILAAVLQLKTDSK 193 Atta cephalotes
XP_004932676 182 NIEQANIQSSHHFNTLIIMYKKPQQLLDMEKEWYEELKKVKPIKD 226 domestic silkworm
EEZ97894     147 APQHEAIQIAHKYNTLIITFKKPKELLEFEKKVLEEVSKIQPKNF 191 red flour beetle
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