5AMB,6S1Y


Conserved Protein Domain Family
Peptidase_M2

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pfam01401: Peptidase_M2 (this model, PSSM-Id:396123 is obsolete and has been replaced by 460196)
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Angiotensin-converting enzyme
Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.
Statistics
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PSSM-Id: 396123
Aligned: 59 rows
Threshold Bit Score: 766.4
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5AMB_A            11 SADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKElYEpiWQQFt-DPQLR 89   human
ASGPB:GKIL_2224   33 VQSVAEAQKFMQRAEGELAELNVKANRASWVGATYITDDTEALSADAQTNLNSAIQRFAIEAKR-FD----NLqmPPELA 107  Gloeobacte...
Q8EE93            43 TPDKAQAIAFIQDAEAQMAQLSIEANRAEWIYSNFITEDTAALSAAVGEKVSAASVKFATEAAK-YA----NVelDPANA 117  Shewanella...
WP_013051597      36 SSKTSEAKQFLIQSEQTLSDLSIEINRAEWIYSNFITDDTAALSASAAEKLTATSVRLATQAAQ-YT----DLalDDTSL 110  Shewanella...
Q0C0U5            40 EERAIEARAFLDDAESQIAAKSHIAAQAYWDQATNITPETSAAAAQQGAEFTKLVVSLANASKD-FD--VSEL--PPAEA 114  Hyphomonas...
WP_012048875      42 APTTAEADAFVADAEKQLADLGIYGAQVAWINATYITDDTDAVNARVGAEFTEMQVRYASGAAR-FD--GLKGl-SYDTR 117  Sphingomon...
BAK67040          32 APDSAQADAFVAAAEKEAFDYSVDASRIMWVNATHITDDTDALAAQAGAKGTEMAVRFALEAAK-YE--QVPGl-SFDTK 107  Sphingobiu...
WP_015456931      30 APTAADADRFVAAAEKELFDLSIPTAQVAWVNATYITDDTDALNTLFGAKNTEASVRLAKEAAR-YD--KVAGf-SFDTR 105  Sphingomon...
PDM63802         307 VKDESEAREWMKGYAEEARKMLHLVTKSGWMYFTDASPTLNRALNEAEEVMARFVRATAQQAKQ-FD--TSAFa-DEALK 382  Pristionch...
XP_030841151      84 gnpspdeivklfladfdrradqefpglmekqwtyytnlteenrqikveakiritefdsesrrtaqtyyhtypshqisydv 163  purple sea...
5AMB_A            90 RIIGAVRTLGSA-NlPLA-KRQQYNALLSQMSRIYSTAKVCLpqKT---ATCWSLDPDLTNILAS-SRSYAMLLFAWEGW 163  human
ASGPB:GKIL_2224  108 RKFKLLKLNLIApPpSDSkEQQELTRLTVGMESEYGKGTYCRs-PVdgkQECLQLN-DLERILRT-SRDPKELLDVWQGW 184  Gloeobacte...
Q8EE93           118 RKLNILRSALVLpApLDPaKNAELAQISSELNGLYGKGKYCF---Ad--GKCMTQP-ELSSLMAE-SRDPAKLLEAWKGW 190  Shewanella...
WP_013051597     111 RKLNILRSSLVLpApLDPeKNAELAGISAQLNGLYGKGKYCF---Dd--GRCLTQP-ELSAIMAE-SSDPKLLLEVWQGW 183  Shewanella...
Q0C0U5           115 RKLQILRSGITLpApSREgAAEELADITTKLDATYSTGKFMFqgRE------IDLL-EASRIIQE-SRDPEELKAVWEGW 186  Hyphomonas...
WP_012048875     118 RKLDILKQSIVLpApATPgAAKELNDLATRLQSAYGKGKGTLrgEE------INGS-DIEAAMGT-NRNPAELKEMWVSW 189  Sphingomon...
BAK67040         108 RKLDIMRSGIVLpApTKPgAAAELNEIATRLQSTYGKGRGTLdgKE------LTGS-DIEAEMANlSHTPAQFSEMWTSW 180  Sphingobiu...
WP_015456931     106 RKLDILRQGIVLpApATEgAATELNALSTRMSSTYGKGRGTLagKE------INGS-DIEEKMGT-VRNPDQLKEMWASW 177  Sphingomon...
PDM63802         383 KQFGYVTFEGMS-TlNVA-DAEAFSTANSNMNKMAADVTVCDldLP---PPCALKKIDLESIART-DKDANRLGHLYTTF 456  Pristionch...
XP_030841151     164 rreleaiastsglptyvdevtqeledvksrmeqryhtakvcrkkgrrarkeclrldpDLKRVMGE-SRDDDELLWAWQGW 242  purple sea...
5AMB_A           164 HNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYN--------SPTFEDDLEHLYQQLEPLYLNLHAFVRRALHR 235  human
ASGPB:GKIL_2224  185 HQ-IARPLRPRYERFVQLSNKGARELGFADTGAMWRSNYDm------sPAQFSAEVERLWQQVRPLYLSLHAYVRTKLGE 257  Gloeobacte...
Q8EE93           191 RE-IAKPMRPLFQREVELANEGAKDLGYANLSELWRSQYDm------kPDEFSQELDRLWSQVKPLYESLHCYVRGELNK 263  Shewanella...
WP_013051597     184 RE-IAKPMRPLFQREVELANEGAKDLGYADLSVLWRSQYDm------kPDEFSNELDRLWGQVKPLYDSLHCYVRGELNE 256  Shewanella...
Q0C0U5           187 HS-IAAPMAPDYTRMVEIANEGARELGYPSLDQMWLSNYDm------pPAQMEAEVQRLWSQVEPLYKELHCYTRGRLNS 259  Hyphomonas...
WP_012048875     190 HDNVGRPMRGDYAKLVEIANKGAVDLGYKDLGAMWRAGYDm------pADDFAKMMDRLWTQVKPLYDALHCYTRTKLNE 263  Sphingomon...
BAK67040         181 HDRVGAPMKADYVRLVDIANEGAKELGFADAGAMWRSGYDm------pPDEFAALTEALWQEVKPLYDALHCYTRTKLNE 254  Sphingobiu...
WP_015456931     178 HDNVGKPMKADYARMVEIANQGAKELGYKDLGAMWRSNYDm------sPDEFARLTDKLWLQVKPLYDQLHCYTRTKLNE 251  Sphingomon...
PDM63802         457 NQNVAA-LKGNYQKIIELTNKGAKMNGFGSGSSMWLSSFDlstkdtppQFDVMKKLNEVFKQVSPFYKQLHAYMRRQIAG 535  Pristionch...
XP_030841151     243 RNETGAPNRDDFQRFVELSNTVAQQSGFDDHGDYQRRQYD--------TPHLEQTMSDLLTNLQPLYDNLHAFIRRRLYD 314  purple sea...
5AMB_A           236 RYG-DRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPD-KP--NLDVTSTMLQQ---------------------GWQA 290  human
ASGPB:GKIL_2224  258 QYG-TQLVPADGPIPAHLLGNMWAQEWGNIYPLAAPAND-QR--GYDLTQLLTAK---------------------KVDE 312  Gloeobacte...
Q8EE93           264 EYG-DAIAPKTGPIPAHLLGNMWAQQWGNVYDLVAPENA-DP--GYDVTELLAQK---------------------GYDE 318  Shewanella...
WP_013051597     257 EYG-DEVVPANGPIPAHLLGNMWAQSWGNVYDKVSPQDA-DP--GYDLTQLLAEH---------------------DYDE 311  Shewanella...
Q0C0U5           260 YYG-EAVQPAAGPIRADLLGNMWAQQWSGVYDILQTDTP-GP--SYDLSERLNEK---------------------GYTP 314  Hyphomonas...
WP_012048875     264 KYG-DAVQAKTGPIRADLLGNMWAQEWGNIYDIVAPKGAgDL--GFDIGDLLVAK---------------------QYDP 319  Sphingomon...
BAK67040         255 KYG-DAVQSPTGPIRADLLGNMWAQEWGNIYPIVAPAGTgDL--GYDIGDLLRAKgfvqttpqtidtpdtpetqrrGYWE 331  Sphingobiu...
WP_015456931     252 KYG-DGVQPRTGPIRADLLGNMWAQEWGNIYDVVAPAGAgDL--GYDTTDLLKAK---------------------GYDA 307  Sphingomon...
PDM63802         536 LYKnPEGLTKDLAIPAHLFGTLEGGDWSAHYLDTRPYDD-EDsvPEEILAAFHGQ---------------------NITQ 593  Pristionch...
XP_030841151     315 IHG-PEVIDLNGPIPSHLLGGMWSHSWSNLFDVAKPYETdDD----DPTEFLQEQ---------------------NYDI 368  purple sea...
5AMB_A           291 THMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADgREVVCHA-SAWDFYNRKDFRIKQC-TRVTMDQLSTVHHEMGHIQY 368  human
ASGPB:GKIL_2224  313 REMFRYGERFFTSLGFAPLPKTFWERSMLTKPRD-RDVVCHA-SAWDIDNLDDVRIKMC-AEVTDSDFVTIHHELGHNFY 389  Gloeobacte...
Q8EE93           319 HRMVKQAESFFTSLGFAPLPDSFWSRSLFLQPKD-RDVVCHA-SAWDLDNLDDIRIKMC-IQKTAEDFTVIHHELGHNFY 395  Shewanella...
WP_013051597     312 VKMVKQAESFFSSLGFDELPDSFWERSLFVQPKD-RDVVCHA-SAWDLDNLDDIRIKMC-IQKTAEDFTVIHHELGHNYY 388  Shewanella...
Q0C0U5           315 LQMVQTAEAFFTSLGLQALPQTFWERSMITKPEG-REVVCHA-SAWDLDDFEDVRIKMC-TQVNAEDFQTVHHELGHNYY 391  Hyphomonas...
WP_012048875     320 VKMVKAGEGFYTSLGFDKLPDSFWTRSQITKPRD-REVVCHA-SAWDIDNVDDLRIKMC-TKVNSDDFVTIHHELGHNFY 396  Sphingomon...
BAK67040         332 KQMFRIGEGFYSSLGFDPLPETFWQRTQFIAPRD-REVVCHA-SAWDVDNRNDIRVKMC-TKVNSDDFVTIHHELGHNYY 408  Sphingobiu...
WP_015456931     308 LKMVKGGENFFSSLGFAPLPDSFWQHSQFTKPAD-REVICHA-SAWDVDNKDDLRIKMC-IKVNGDDFTTIHHELGHNYY 384  Sphingomon...
PDM63802         594 KEMFVKAYRYFKAVGFPKLPKSFWTNSVFARVWS-KDMICNPpAAIDMRDGEEFRVKMC-AQLGDTDFKQAHSLLAQTFY 671  Pristionch...
XP_030841151     369 RRLYETAEEFYTSMGYEELPESFWENSVFGQPQDgRNVSCEP-TSWDFHNQTDFRITTCsSEVTIDELSKAHNILGHTQY 447  purple sea...
5AMB_A           369 YLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLL--DRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWR 446  human
ASGPB:GKIL_2224  390 QRAYKTQPPLFQNSANDGFHEAVGDTIALSV-TPDYLVKVGLL---GKAPGPESDTGFLLKQALDKVAFLPFGLLIDQWR 465  Gloeobacte...
Q8EE93           396 QRAYKQQPFLFKNSANDGFHEAIGDTIALSI-TPSYLKQIGLL---EEVPDASKDIGLLLKQALDKIAFLPFGLMIDQWR 471  Shewanella...
WP_013051597     389 QRAYKNQPFIFKNSANDGFHEAIGDTIALSI-TPSYLKQIGLL---DEVPDASKDIGLLLKQALDKVAFMPFGLMIDQWR 464  Shewanella...
Q0C0U5           392 QLAYRNQDHLYKNGAHDGFHEAIGDFVALSI-TPEYLEQIGLIt-AEEKPGADADTALLLNTALDKIAFLPFALSVDSWR 469  Hyphomonas...
WP_012048875     397 QRAYNKQPYLYLNGANDGFHEAIGDFIALSV-TPDYLVRIGLLd-PAKVPSADKDIGLLLRQAMDKVAFLPFGLLMDKWR 474  Sphingomon...
BAK67040         409 QRAYQKHGYLYLNGANDGFHEAIGDFIALSI-TPQYLVQIGLLd-PAKVPSADKDIGLLLRQAMDKVAFLPFGLLIDRWR 486  Sphingobiu...
WP_015456931     385 QRAYNKQPYLYLNGANDGFHEAIGDAIALSI-TPDYLVRIGLLd-PAKVPPADKDIGLLLRQAMDKVAFLPFGLLVDKWR 462  Sphingomon...
PDM63802         672 QFLYRKQPFSFREAANPSFNEAIANVFSILSSNTDYLFSQSLIapDSLVPKESQVINRLYKEALTHFVKLPFDLAADEWR 751  Pristionch...
XP_030841151     448 QNSYSHQPTAFREPASPALYEAIADLTSSEVFSPSYLRQLGLSl-DERNDD-KIQLNGLMRTALDSLALLPYANAVDQWR 525  purple sea...
5AMB_A           447 WGVFSGRTPPSRYNFDWWYLRTKYQGICPPVT-RNETHFDAGAKFHVPN-VTPYIRYFVSFVLQFQFHEALCKEAGYEGP 524  human
ASGPB:GKIL_2224  466 WKVFSGETQPKDYNKSWWELRERYQGIAPPLA-RSEADFDPAAKYHVAA-NTPYIRYFLARILQFQFHRALCREAGYTGP 543  Gloeobacte...
Q8EE93           472 WKVFSGEITPAQYNQAWWELREKYQGVKAPTP-RSETDFDPGAKYHVPG-NVPYTRYFLAHILQFQFHKALCETAGDKGP 549  Shewanella...
WP_013051597     465 WKVFSGEITPDQYNQAWWDLREKYQGVKAPIE-RSEADFDPGAKYHVPG-NVPYTRYFLAHILQFQFHKSLCETAGDTGP 542  Shewanella...
Q0C0U5           470 WDVLSGETAPENYNQSWTDIRLKNQGIIPPGP-RPADAFDPGAKYHIPG-NTPYLRYFLSFIMQFQFHKAACEQAGWEGP 547  Hyphomonas...
WP_012048875     475 WGVFSGQISPASYNKAWTDLRLQYQGIVPPEA-RDEGDFDPGAKYHIPG-NTPYARYFLARILQFQFYKAACEQAGWKGP 552  Sphingomon...
BAK67040         487 WGVFDGSIRPADYNKAWTDMRLRYQGIVPPTD-RPADSFDPGAKFHVPG-NTPYTRYFLARILQFQFYEAACRQAGWKGP 564  Sphingobiu...
WP_015456931     463 WGVFDGSIAPQDYNKAWTALRLQYQGITPPVE-RGADAFDPGAKYHVPA-STPYTRYFLARILQFQFYKAACDQAGWKGP 540  Sphingomon...
PDM63802         752 IEYFNGKTVPSKLNERWWQLRERYEGVRHVSPtVNASTLDALINTAIVQeHSPATRQMITYVMQFQILKALCPEGSI--- 828  Pristionch...
XP_030841151     526 WGVFNGSIQPDRYNSEWWDLRSEYEGIEPGVE-RTDADFDPGAEFNIVS-DSSYAKHFLGQIMKFQFLKSLCEAAGHTGP 603  purple sea...
5AMB_A           525 LHQCDIYRSTKAGAKLRKVLRAGSSRPWQEVLKDMVGLDALDAQPLLKYFQLVTQWLQEQNqqNGEVLGW 594  human
ASGPB:GKIL_2224  544 LHRCSIYANRAAGTKLAAMLAAGQSQPWPDTLYAMTGERQMDASAMLDYFAPLKSWLDAQN--QGKKVGW 611  Gloeobacter kilaueen...
Q8EE93           550 VHRCSIYGNQAAGEKLNRMLELGSSQPWPMALKEVTGTETMDANAVLDYFAPLKTWLDEQNkaANRQCGW 619  Shewanella oneidensis
WP_013051597     543 VHRCSIYGNKAAGSKLNTMLEMGLSRPWPDALKVVTGSPEMDASAVLDYFAPLQVWLNEQNtqAKRQCGW 612  Shewanella violacea
Q0C0U5           548 LHRCSIYGNKEVGRRFEEMMEAGMSQPWPDTLEKFTGTREMDGSAIIEYFDPLMVYLKEEN--AGQSCGW 615  Hyphomonas neptunium...
WP_012048875     553 LHRCSFYGNKEVGAKLDAMLKMGASKPWPDALQAFTGSREIDGSAMIAYFKPLMTWLEKQN--KGQRCGW 620  Sphingomonas wittichii
BAK67040         565 LHRCSFYGNKEVGKRLNAMLEMGASKPWPDALEAFTGSRKMSGKAMLAYFAPLGKWLDQQN--KGKQCGW 632  Sphingobium sp. SYK-6
WP_015456931     541 LHRCSFYGNKEVGANLNKMLEMGMSKPWPDALQAFTGSREMDGTAMIAYFKPLMTWLEQQN--KGKTCGW 608  Sphingomonas sp. MM-1
PDM63802         829 LSEGCIL-SEDTTGKLREAMEKGSSINWLEALKIVTGKGELDVAPLLEYYEPLINWLQNTNevDQVIVGW 897  Pristionchus pacificus
XP_030841151     604 IQDCNLYGNRVAGQLITTAMQlgktrswteifyiltqqynldtsplleyfqplneflerenrrngdstgw 673  purple sea urchin
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