1G6I,1FO3


Conserved Protein Domain Family
Glyco_hydro_47
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pfam01532: Glyco_hydro_47 (this model, PSSM-Id:396217 is obsolete and has been replaced by 460241)
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Glycosyl hydrolase family 47
Members of this family are alpha-mannosidases that catalyze the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).
Links
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Statistics
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PSSM-Id: 396217
Aligned: 99 rows
Threshold Bit Score: 341.071
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1G6I_A        46 MFLESWRDYSKHGWGYDVYGPIEHTSHNMPrgnQPLGWIIVDSVDTLMLMynsstlyksEFEAEIQRSEHWINdVLDFD- 124  baker's yeast
Q0U7J6       189 VFQKSWSGYKEFAWLHDELKPHSGTFRDPF---AGWGATLVDALDTLWVM---------GMKDEFSAAAQAVD-QIDFT- 254  Parastagonospo...
Q5KDN4       235 GFKHAWEAYKRHAWGHDEVRPVSLTHSDPF---NGWGATIVDSLDTLLLM---------GFSNEYNLCRPHVN-QLNFHw 301  Cryptococcus n...
XP_001591293 203 EFLKSWKGYKKFAWGHDELSPVSTKFRDPF---CGWAATLVDGLDTLWIM---------GLYEEFEEAVKAVE-KIDFT- 268  Sclerotinia sc...
Q5BBN5       107 AFKHAWKGYKSNAWLRDELSPLSGGYRTSF---AGWAATLVDALDTLIIM---------DLTDEFEEALEALE-HIDFS- 172  Aspergillus ni...
Q2UJG7       109 AFKHAWKGYKEHAWLRDELSPLSAEYRESF---GGWAATLVDSLDTLIIM---------GLMDEFEDALQAIE-HIDFS- 174  Aspergillus or...
CAK44699     103 AFQHAWKGYRNNAWLEDELSPISGGHRETF---AGWAATLVDSLDTLVIM---------GLTEEFEEAVKALE-YIDFT- 168  Aspergillus niger
Q4WPQ3       110 AFTHAWKGYKQHAWMRDELSPLSARYRTTF---AGWAATLVDALDTLVIM---------GMENEFKDALHAIE-SIDFT- 175  Aspergillus fu...
EDN93472     104 NFTHAWNGYVSHAWLKDEVMPLSGGSMDPF---GGWAASLVDTLDTLWIM---------GMHSQFKAAVEAIQ-VIDFS- 169  Sclerotinia sc...
EDN09338     103 AFLHSWKGYKKYAWLKDELSPVDGGGRNPY---GGWGATLVDTLDTLWLM---------GLEKEFKEAVAAVK-HIDFS- 168  Histoplasma ca...

1G6I_A       125 --------------I-DA-EV-----------NVFETTIRMLGGLLSAYHLSdvleVGNKTVYLNKAIDLGDRLALAFlS 177  baker's yeast
Q0U7J6       255 --------------TtPRaDI-----------PLFETTIRYLGGLLAAYDLS----GKKHKNLLAKATELADILLSAF-D 304  Parastagonospo...
Q5KDN4       302 vngrdwndgyvseeLsGSgEVyalnrdktvglAVFETGIRYLGGLLGAYDLS------GDDLLLERAVDLADILSTAF-K 374  Cryptococcus n...
XP_001591293 269 --------------TtPRmEI-----------PVFETTIRYLGGLLAAFDVS----DGKFQVLLDKATELAEILMGAF-D 318  Sclerotinia sc...
Q5BBN5       173 --------------TtDSiQI-----------NVFETNIRYLGGLLGAHDLT----EGRYPILLKKATEIADFLYGSF-D 222  Aspergillus ni...
Q2UJG7       175 --------------TtGAtQI-----------NVFETNIRYLGGFLGAYDLT----NGSYPILLKKAVEVADLIYGSF-D 224  Aspergillus or...
CAK44699     169 --------------TtSAiQI-----------NVFETNIRYLGGLLGAYDLT----QGKYPILLKKAVEIADMIYGSF-D 218  Aspergillus niger
Q4WPQ3       176 --------------TpDAtQI-----------NIFETTIRYVGGLLGAYDLT----DGKHPILLKKAVELADMIYDAF-D 225  Aspergillus fu...
EDN93472     170 --------------TcALeQI-----------NVFETTIRYLGGFLSAYELS----GEKYPVLLQKATEMGEMLYKSF-D 219  Sclerotinia sc...
EDN09338     169 --------------SsDTsLL-----------NVFETNIRYLGGFLAAHDLT----KGAYPILLQKAVEVGDLLYVAF-D 218  Histoplasma ca...

1G6I_A       178 TQTGIPYSSINLhsGQAVKN--HADGGASST-AEFTTLQMEFKYLAYLTGNRTYWELVERVYEPLYKNNdlL-NTYDGLV 253  baker's yeast
Q0U7J6       305 TPNRMPETYYYWrpQFASQN--HRASVRVVL-AEIGSMSMEFTRLAQLTGDHKYYDAIARITDNLEEFQ--NnTRLTGMW 379  Parastagonospo...
Q5KDN4       375 TGSGLPAGRMD----PGTKD--EMIRLGTVSlAEVGSMSLELIRLSQITKDRKWFDLAQRAMDYIHERVi-PrGTHSPLI 447  Cryptococcus n...
XP_001591293 319 TPNRMPVLHYRWkpVFASQP--HRASSRSNL-AELGSLSMEFTRLAQLTGEQRYYDAVARVTNALSEWQdrNsTYIPGVF 395  Sclerotinia sc...
Q5BBN5       223 TRNRMPQSRWEWtrSASGQT--IHPSGNTIL-AELGSLNLEFTRMSQLTGDQKYFDAIQRISDHLESAQ--KeTLVPGLW 297  Aspergillus ni...
Q2UJG7       225 TRNRMPQSRWEWtrSALGMG--IQPSRNTIL-AELGSLNLEFTRMSQLTKDPKYFDAIQRITDKLESAQ--SrTQVPGLW 299  Aspergillus or...
CAK44699     219 TRNRMPQSRWEWtrSADGLS--IEPGRNTIL-AELGSLNLEFTRLSQLTKDPKYFDAIQRIADFLEDTQ--EtTDVPGMW 293  Aspergillus niger
Q4WPQ3       226 TTNRMPQSRWQWs-RS-ARGlsIQPSRQTIL-AELGSLNLEFTRLSQLTHDPKYFDAVQRITNVLDDAQ--NkTKIPGLW 300  Aspergillus fu...
EDN93472     220 TPNHLPILRWYYhiAATGAK--QEADDNVLE-SEIGSLTLEFTRLGQITGDPRFYDAVQRIMNIFDEQQ--SmSKLPGMW 294  Sclerotinia sc...
EDN09338     219 TPNRMPVLRWYWhgARDGYH--QEASMLTVL-AEFGSLSLEFTRLSQITGDPKYYDAIQRITTILQEHQ--FnTKVPGLW 293  Histoplasma ca...

1G6I_A       254 PIYTFPDTGKFG-A------------------------------------------------------------------ 266  baker's yeast
Q0U7J6       380 PTYLDASGCGKV-Hadplaqarlndhntplqpstvpaptqgkkeiplqlpdpvvlapngvnptyvaspeedtialgnag- 457  Parastagonospo...
Q5KDN4       448 PMWFQPDAPLTTsMh----------------------------------------------------------------- 462  Cryptococcus n...
XP_001591293 396 TEEVDASGCNRT-Atlikqnekkeaalaketalsdpetaalldeapegykppspeteikgsksrkkprpgdkmlemqvlp 474  Sclerotinia sc...
Q5BBN5       298 PMMVDAESMRFSd------------------------------------------------------------------- 310  Aspergillus ni...
Q2UJG7       300 PMMVDAHDMQFTd------------------------------------------------------------------- 312  Aspergillus or...
CAK44699     294 PMMVNAKDLEFAd------------------------------------------------------------------- 306  Aspergillus niger
Q4WPQ3       301 PMMVNAEDLEFT-D------------------------------------------------------------------ 313  Aspergillus fu...
EDN93472     295 PVIVNAKDKNFV-Dy----------------------------------------------------------------- 308  Sclerotinia sc...
EDN09338     294 PVSVDARTPSFE-Rd----------------------------------------------------------------- 307  Histoplasma ca...

1G6I_A           --------------------------------------------------------------------------------      baker's yeast
Q0U7J6       458 --------------------------kgtirnwdgkplerrqldvevedppmvqagsqddslpdvapaetalptlpvcve 511  Parastagonospo...
Q5KDN4           --------------------------------------------------------------------------------      Cryptococcus n...
XP_001591293 475 gepgkahikgwgdgnakkrdlgesalsasttvsttpppaanhppnhppvyrngnglghsfapelpdlpgtggagdwdcvk 554  Sclerotinia sc...
Q5BBN5           --------------------------------------------------------------------------------      Aspergillus ni...
Q2UJG7           --------------------------------------------------------------------------------      Aspergillus or...
CAK44699         --------------------------------------------------------------------------------      Aspergillus niger
Q4WPQ3           --------------------------------------------------------------------------------      Aspergillus fu...
EDN93472         --------------------------------------------------------------------------------      Sclerotinia sc...
EDN09338         --------------------------------------------------------------------------------      Histoplasma ca...

1G6I_A       267 -----------STIRFGSRGDSFYEYLLK---------QYLLTH----ETLYYDLYRKSMEGMKKH-LLA-QSKPS--SL 318  baker's yeast
Q0U7J6       512 qgfvsssefgrEEYTLGGLSDSTYEYLPK---------QYLLLGg--qVEKYQTMYEQSMDVVKEHlIFR-PMLPKedDV 579  Parastagonospo...
Q5KDN4       463 -----------GGLTFGGLADSYYEYLIK---------TYKLLGtsevSQVWRDVYERSIDKAKETlYVDiDIVPGr-NI 521  Cryptococcus n...
XP_001591293 555 qgleaytqggrQKFSMGGGQDSTYEYYPK---------QYMLLGg--lEEVYRKMYMKTIPAIRDYmLFR-PMVPGddDI 622  Sclerotinia sc...
Q5BBN5       311 -----------PRYTIGGMADSAYEYLPK---------EHMLLEg--rTQQYQRMYESAIPAIKERmLFR-PMTKGgeDI 367  Aspergillus ni...
Q2UJG7       313 -----------PRFTVGGMADSTYEYLPK---------EHILLGa--qTDQYRKMYDAAINSIKKRlLFR-GMTKDgkDI 369  Aspergillus or...
CAK44699     307 -----------PRFTIGGMADSTYEYLPK---------EHMLLGg--qTNQYRRMYNSFMKAMKSRlLFR-PMTEDgrDI 363  Aspergillus niger
Q4WPQ3       314 -----------PRFTVGGMADSTYEYLPK---------EHMLLGa--rTDQYRKMYAAAMEAIKKRlLFR-PMTKNgeDL 370  Aspergillus fu...
EDN93472     309 -----------WGFTIGGMADSLYEYLPK---------QHLLLGg--aTQQYRRMYEYAMIAMRRNiFFR-PMTKNgeDI 365  Sclerotinia sc...
EDN09338     308 -----------RRFTFGGMADSLYEYLPKvrsyyryklEYLLLGg--rNQQYKDMYEKALEVAKKHiFFR-PMTKDsdDI 373  Histoplasma ca...

1G6I_A       319 WYIGEREQG------LQGQLSPKMDHLVCFMGGLLASGSTEGlSIhearrrpffsKSDWDLAKGITDTCYQMYKQSSSGL 392  baker's yeast
Q0U7J6       580 LFCGKLNVPsrvkdlVPGDLTGEYAHLTCFAGGMFGMGAKLF-NR----------PNDLEIAKKLTEGCVWAYDMTQTGI 648  Parastagonospo...
Q5KDN4       522 LAVGKL---------ENGRLIPELEHLTCFIGAMLGLGAKLL-DR----------PGDMRDAERVTASCYWLSADTPTGL 581  Cryptococcus n...
XP_001591293 623 LISGKVTSTgd---mEENLLIPEVTHLTCFIGGMVGMSAKIF-GI----------EGDLEIAKKLTDGCVWAYGATPLGI 688  Sclerotinia sc...
Q5BBN5       368 LFSGNIYAGtk---aSRKKVEAQAEHLKCYLGGTIGIGAKVF-NR----------PEELSIARKLTDGCIWAYDIMPSGI 433  Aspergillus ni...
Q2UJG7       370 MFAGNIRST------SKSVIEPQFEHLKCFLGGTVGIGAKVF-DR----------PEELSIARKLTDGCIWAYDIMPTGI 432  Aspergillus or...
CAK44699     364 LFAGNLRVTgs---sTRSNLEPQWEHLKCYLGGTVGIGSKVF-DR----------PEDLAVARKLVDGCIWAYDIMPTGI 429  Aspergillus niger
Q4WPQ3       371 LFAGNTHTGl----aSNAPPEPQWEHLKCFFGGTVGIGAKIF-NR----------PEELSIARKLTDGCIWAYDVMPTGI 435  Aspergillus fu...
EDN93472     366 RLPGNVDSDgkt-lvTELKTQGEAQHLGCFAGGMVAIGAKIF-EN----------EKDLELARKLTEGCLWAYENMPLGI 433  Sclerotinia sc...
EDN09338     374 LISGTAFIAg----tTRVTLRPQGQHLTCFVGGMVALAAKVF-SR----------PEELDIARKLTEGCIWAYKATPSGV 438  Histoplasma ca...

1G6I_A       393 APEIVVFN----DGNi-------------kQDGWWRSSVGDFFVK----------------------------------- 420  baker's yeast
Q0U7J6       649 MPESFEAI----PCEn-------------aQECAWNETLYFETIDpnadlrheaykgqmqifhsqvasasswyeeqlaam 711  Parastagonospo...
Q5KDN4       582 QPEVVEWYapheTSAmyenvsisgggrhhpLIFSEDESKDRDGMYrdrngvlrwtednepvlytdrek------------ 649  Cryptococcus n...
XP_001591293 689 MPEGSEVI----ACEs-------------vEHCSWNQTLYYERLDpsahyrdanlkeyienkekldaeakdmnmspmdad 751  Sclerotinia sc...
Q5BBN5       434 MPEVMYLS----PCDd-------------lENCPWDEQKWYRDVRarppphaniadteeaa------------------- 477  Aspergillus ni...
Q2UJG7       433 MPEALYIS----PCKn-------------tDDCEWDEQKWHTDVLrrfaknsqgeevaq--------------------- 474  Aspergillus or...
CAK44699     430 MPEILHLT----VCKd-------------dENCQLPQSSHPTSTSkdgkkl----------------------------- 463  Aspergillus niger
Q4WPQ3       436 MPESMHLS----PCQs-------------mDHCEWDEQKWYQDVRrrlakgskekdtvqea------------------- 479  Aspergillus fu...
EDN93472     434 MAEKMHMV----PCEn-------------eNYCPWDEQKWLEGINkdtegnetvnek----------------------- 473  Sclerotinia sc...
EDN09338     439 MPETFEVV----PCEd-------------sRDCKWRPESWFIGEIhegasdsdyerm----------------------- 478  Histoplasma ca...

1G6I_A           --------------------------------------------------------------------------------      baker's yeast
Q0U7J6       712 tapakvvdpsypvlatptpiyadtldkrqlahlvd-------------------------daetivggaeepqhlptkvq 766  Parastagonospo...
Q5KDN4           --------------------------------------------------------------------------------      Cryptococcus n...
XP_001591293 752 reqnalakaktvggpqgytghretdslkkdsleiksndagafkpkdepasltkrqshadtmdgpekqtmfeqksaktkae 831  Sclerotinia sc...
Q5BBN5           --------------------------------------------------------------------------------      Aspergillus ni...
Q2UJG7           --------------------------------------------------------------------------------      Aspergillus or...
CAK44699         --------------------------------------------------------------------------------      Aspergillus niger
Q4WPQ3           --------------------------------------------------------------------------------      Aspergillus fu...
EDN93472         --------------------------------------------------------------------------------      Sclerotinia sc...
EDN09338         --------------------------------------------------------------------------------      Histoplasma ca...

1G6I_A       421 --------------------------------------------------PLDRHNLQRPETVESIMFMYHLSHDHKYRE 450  baker's yeast
Q0U7J6       767 plqddgeanleqsqtlpafpyiytpspplnhkdyvqnrikderlppgvtrIGARNYILRPEAIESVWYMYRITGDNHWRE 846  Parastagonospo...
Q5KDN4       650 ----------------------------kkngqtpikyaqrlkgtptgarKVSTRGLNRPETIESIFYMYRITGDRKWQE 701  Cryptococcus n...
XP_001591293 832 lesmaggrqlekgqkplgseslpdplrplshkeyvesrikqeslppgftsIFTRKYILRPEAIESVWYMYRITGDKSWQE 911  Sclerotinia sc...
Q5BBN5       478 -----------------------------------klliekfdlvpgvaeIADARYMLRPEAIESVFIMYRITGDKKYQD 522  Aspergillus ni...
Q2UJG7       475 ------------------------------------qiissnklppgvteIPDASYNLRPEAIESVFIMYRITGDKELQD 518  Aspergillus or...
CAK44699     464 --------------------------------------------ppgvvdIPDPKYLLRPEAIESVFIMYRITGDRSLQD 499  Aspergillus niger
Q4WPQ3       480 -----------------------------------ktiirdsglqpglteITDPRYLLRPEAIESVFIMYRITGDKKLQD 524  Aspergillus fu...
EDN93472     474 --------------------------------------iqqhrlipgvtkFDDGRYILRPEAIESVFILYRITGDPDLQE 515  Sclerotinia sc...
EDN09338     479 --------------------------------------greqgkvagfsaIIHGGYSLRPEAIESVFILYRITGDKTLQD 520  Histoplasma ca...

1G6I_A       451 WGAEIATSFFENTCVdCNdpklrRFTSLSDCITL-PTKKSNNMESFWLAETLKYLYILFLDE--FDLTKVVFNTEAHPFP 527  baker's yeast
Q0U7J6       847 VGWRMFLAVDKHTST-KY-----GNSAIDDVTQL-SPSLNDEMESFWLAETLKYFYLLFETEdvLSLDDWVLNTEAHPFR 919  Parastagonospo...
Q5KDN4       702 KGWKMFTSWMNASTV-DG-----GFSSVEDVTKL-PVRFGDNMESFALAETFKYHFLLQSEPdvLSLDDYVLNTEAHPFL 774  Cryptococcus n...
XP_001591293 912 KGWKMYEAVINATST-EF-----GNSAIYDVTAE-EAYRIDEMESFWLAETLKYFYLLFSTPetISLDEWVLNTEAHPFK 984  Sclerotinia sc...
Q5BBN5       523 AAWRMFNSIEKATRT-KY-----AHAAINDVREE-KPKQLDYMESFWLAETLKYFYLIFSEPelISLDDYVLNTEAHPFK 595  Aspergillus ni...
Q2UJG7       519 AAWRMFRSIEKMTLT-RY-----GHAAISDVRNP-QSSQLDYMESFWLAETLKYFYLIFSEPdvVNLDEYVLNTEAHPFR 591  Aspergillus or...
CAK44699     500 AAWRMFQNIDKMTRT-SF-----GHAAISDVRDP-ESPQMDYMESFWLAETLKYFYLIFSEPdlVNLDEYVLNTEAHPFK 572  Aspergillus niger
Q4WPQ3       525 DAWRMFQSIEKATRT-KY-----AHAAIDDVRDV-KATQLDYMESFWLAETLKYFYLIFSEPglVSLDDYVLyvllsyev 597  Aspergillus fu...
EDN93472     516 RAWTMFNNIIKHTIT-DI-----AHAALDDCTVSeNPRKADRMESFWMAETLKYFYLIFADPdlISLDEYVLNTEAHPLK 589  Sclerotinia sc...
EDN09338     521 KGWEMFFAIEKHAKT-EF-----AYGGLDDVASP-NPTITNRMESFWTGETLKYFYLLFSEPdlASLDNTLI---AHGLG 590  Histoplasma ca...
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