Conserved Protein Domain Family
HSD3
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pfam15244: HSD3 (this model, PSSM-Id:405841 is obsolete and has been replaced by 464584)
Spermatogenesis-associated protein 7, or HSD3
Spermatogenesis-associated protein HSD3 also goes by the name of spermatogenesis-associated protein 7 or SPAT7. The family carries a single transmembrane domain. It functions in several tissues, and is expressed in the developing and mature mouse retina; it is expressed in multiple retinal layers in the adult mouse retina. Mutations lead to LCA disease, or Leber congenital amaurosis, which results in a number of retinal dystrophies. The disease- phenotype is characterized by severe visual loss at birth, nystagmus, a variety of fundus changes, and minimal or absent recordable responses on the electroretinogram (ERG).
Links
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Statistics
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PSSM-Id: 405841
Aligned: 13 rows
Threshold Bit Score: 463.842
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EHH63817       9 ATSVLPRYGPPCLFKGHLSTKSN----AFCTDSSSlRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPVSMSTSVKYADQQ 84  crab-eating mac...
XP_003472388   9 ASPVLPRCSPPCLFKGHLSTKSN----AFCTDSSSlRLTTLQLIKNHMAVHYNKILSAKAAVDCSIPVSMSASIKYADQQ 84  domestic guinea...
Q80VP2         9 ATSVLPRYSPPCLFTGHLSTKSN----AFCTDSSSlRLSTLQLVKNHMAIHYNKILSAKAAVDCSIPVSVNTSIKYADQQ 84  house mouse
XP_007472732  14 TNYVMPRYVPSSPFTGHLSTKSN----AFCTDSSSlRLSTLYLIKNHMAVHYNKILSAKAVVDCSMPVSMISSVKYSDQQ 89  gray short-tail...
XP_012402844   1 MPRYDPSSPFTGHLSIKSNAFCT----DSSSLRLStLYLIKNHMAVHYNKILSAKAVVDCSMPVSMTSSIKYSDQQRREK 76  Tasmanian devil
4_pfamImport   1 EYRAIPRYGPASPFKGHLSTKSN----AFCIDSSSrRLSNQYLIRDHMAVHYNKILSAKAAVDCSVPKSRVNSIKFSDQQ 76 
2_pfamImport   1 HTSVISFFKSASPFKGQLSTKSN----AFCIDSSR-SLTNQYLIRDHLMFHYNRILSAKAAVDCSVPRSRLNSIKLADQQ 75 
XP_004010880  23 AASVLPTFDPSCLFKGHLSTKSN----AFCTDSSSlRLSSLQLVKNHMAVHYNKILSAKAAVDCSVPLSMSASIKYADQQ 98  sheep
XP_006087046   9 SSSVLPRSVPPCLFKGHLSTKSN----AFCTDSSSlRLSTLHMVKNHMAVHYNKILSAKAVVDCSVPLSIGACIKYADQQ 84  little brown bat
XP_023483992   9 ATSVLLRCSPPDLFKGHLSTKSN----AFCTDSSSlRLSTLHLVKNHMAVHYNKILSAKAIVDCSVPLSMSTSIKYADQQ 84  horse
XP_010587096   4 SRRVLPRYDPPCLLKGHLSTKSN----AFCTDSSSlRLNTLHLVKTHMAAHYNKILSAKAAVDCSVPVSISTSIKYADQQ 79  African savanna...
XP_015205573  14 NVTPVPRYSLAGPFKGHMSIKSS----PYCPGSSN-KLTNQYMIQDHMMFHYKKVLSAKAAVDSTAPKSLLSSVKYSDQQ 88  spotted gar
XP_015205572  14 NVTPVPRYSLAGPFKGHMSIKSSrksaAYCPGSSN-KLTNQYMIQDHMMFHYKKVLSAKAAVDSTAPKSLLSSVKYSDQQ 92  spotted gar

EHH63817      85 RREKLKKELARCEKEFKLTKTAMRANSKNNSKSLFNTLQKPSGEPQIEdDMLKEEMNGFSSFARSLVPSSERlHLSLHKS 164 crab-eating mac...
XP_003472388  85 RREKLKKELERCEKEFKLNKTSIQANSKKRLKSIFNTLQKPAGEPQNQ-GMLIEEMNGFPSFTKALLPSSET-QLRLRKS 162 domestic guinea...
Q80VP2        85 RREKLRKELARCEKEFKLSKSAMQTNSKMNSKFFVNSLQKPSGEPQDQ-DVFIEEMTRYPSFSKSLIPSSEGlHLSLPES 163 house mouse
XP_007472732  90 RREKLKKELAQCEKELKSAKISTQTSNKFSPSPRLSPSRKLSEELPDK-DEETEEENDFPSLSKSLPPASDKqFPDFSIL 168 gray short-tail...
XP_012402844  77 LKKEMAQCEKDSKLSRSSTQTSNKSSPSPISSMGLKLSEKVQDKDEET-EEKNEFLSLSKSLPPALNKQFSDfSYHEKTV 155 Tasmanian devil
4_pfamImport  77 RREKLKKEVEKCEKEMISSRNGSRTSSRESRRPMSAFYRKPASGELGR-DIEEATSNNPRSRCKVILQYFSRlELGVWNA 155
2_pfamImport  76 RREKLKKKIARYEKEMSVGKNASRSSSRESGKLLSTSFGKPS----DKgGRYVDKINSFNYFTAKTTIVAAYkLSCVKKH 151
XP_004010880  99 RREKLKKELARCGRELKFTKTTVH--PKSHSKSLLNTLQKPSGEPQDEnGLLIEEVNEFPSFTQSPVISSER--LSLPKS 174 sheep
XP_006087046  85 RREKLRKEIAQCERELQGTKTTVQANSKNNSKSLLNTLQKPAEEPRNEgNMLIEEVNEYASFARSPGTSSERlHLSLPKS 164 little brown bat
XP_023483992  85 RREKLKKELAQCERGLKLTKTAMRANSKNNSKSL-NTLQKPSGEPHDEdGVLLKEVNGFPSFTRSRVTSSERlHLSAPKS 163 horse
XP_010587096  80 RREKLKRELARCEKELRLAKTIRQANSKNNSRSILSTLQKPAGEPQDEaDVLIEGIREFPSFARSRVPSSERlLLGPCKS 159 African savanna...
XP_015205573  89 RRERLKKKVSQCETKVISAQTGLQKTSTNNTRPSSADIVQSCASLQGNdEGDCFHYLESHLISSPRFAASCHsSQFLCQS 168 spotted gar
XP_015205572  93 RRERLKKKVSQCETKVISAQTGLQKTSTNNTRPSSADIVQSCASLQGNdEGDCFHYLESHLISSPRFAASCHsSQFLCQS 172 spotted gar

EHH63817     165 DKVITNGPEKNSSSS-PSSVDYAASGPRK---------------------PGSGTLYGR--RPRSTFPNSHRFQLVISKA 220 crab-eating mac...
XP_003472388 163 DRVPMNGASQNGSSS-PSSVDCITSDPRN---------------------LGPGAVHGR--RPRSAFPSSHRFQVVISKA 218 domestic guinea...
Q80VP2       164 SKMLMSGTQKHASTS----------PSRH---------------------SGCGHGCDR--RPR----SAHQFQVALAKT 206 house mouse
XP_007472732 169 EKSFRNETRRSYSTS------GTSSPRRQ---------------------FCVSSRNAAt-GSTKNTKNPRMFQLFASKA 220 gray short-tail...
XP_012402844 156 RNETRRAFSASGIAN------PRRQTSVS---------------------SHNVSNGGGskNTKNPRRFQLFTSKAPSGD 208 Tasmanian devil
4_pfamImport 156 SQSVSSSPKKASNASlLSSSTSTSSLQRL---------------------HSKMSWSSS--SDSITNKHSQKMHNAESKA 212
2_pfamImport 152 SRNRSNASNSNSSVS------TSSTPRKR---------------------SGVSSCCSS--DSFVSISHSQRRQESNSKI 202
XP_004010880 175 QNVLTNCTEKNSSCS-MSSMDYAASGSKK---------------------PSSGTSYGR--GPRGTFPGSQKFQLVISKA 230 sheep
XP_006087046 165 NDSLTGGTEKNFGSF-LSSIDCTTSRPRK---------------------THSATSNSR--RPRST--NSHRSQLVVKKT 218 little brown bat
XP_023483992 164 SKVLTNSPEKNSSSS-QSSMDYTTSGPRK---------------------PCSGTVYGR--RPRSTVPNSYRFELVISKA 219 horse
XP_010587096 160 DKVLTSGTEENSSSS-LTSMGHTVSRPRKlssarpysrgprsagprsacpS------------------PHRFQLVISKA 220 African savanna...
XP_015205573 169 SRSGQKATKPFYRSSsESGFRSPFTRREH---------------------STQSYTSSS--GIFKSKISYNSFHDPNQKT 225 spotted gar
XP_015205572 173 SRSGQKATKPFYRSSsESGFRSPFTRREH---------------------STQSYTSSS--GIFKSKISYNSFHDPNQKT 229 spotted gar

EHH63817     221 PSGDLLDKHAELFSNKQlPFTPRTLKTEAKSFLSQYRYYTPAKRK--KDFADQRIEAETQTEL----------SFKSELG 288 crab-eating mac...
XP_003472388 219 PSGDLLEKHADFFSNKQlPFTPRTLKTEAKSFLSQYRYYTPAKRR--KDITDPQIEGETQTELs---------SCHSDLG 287 domestic guinea...
Q80VP2       207 PSGDLLEKHSDLFSNKQsPFTPRTLKTEAKSFLSQYRYYTPAKRR--KDFSDQRMEAETQTELs---------SFNSELG 275 house mouse
XP_007472732 221 PSGDLLEKHSAHFTNQElPFTPRTLKTEAKSFLSQYRYYTPAKRK--KDFQDQLIEAETQTELs---------SFKTHFI 289 gray short-tail...
XP_012402844 209 LLEKHSARFTNKQLPFTpRTLKTEAKSFLSQYRYYTPAKRKKETQ--DHLIEAETQTDISSFKt---------YFVTSEL 277 Tasmanian devil
4_pfamImport 213 SSKDLLEAHSEYFTNGQqPFTPRTLKSDAKSFLSQYRYYMPARSKl-LDVFNQQVEAETQTDI----------IFSP-LG 280
2_pfamImport 203 YSGDLLDRHSELFTSSRkPFTPRTLISDAKSALLGYRYYTAAQRKr-KKHCKRHVEAETQTDVi---------SFPSADK 272
XP_004010880 231 PSGDLLDKHSEHFSNRHlPFTPRTLKTEAKSFLSQYRYYTPARRK--KNFTNRRIEAETQTELs---------SFKSDFE 299 sheep
XP_006087046 219 SSGDLLDKHSKLFSNGHlPFTPRTLKTEAKSFLSQYRYYTPAKRK--KDFTDQRIEAETQTELs---------SFKPDFE 287 little brown bat
XP_023483992 220 PSGDLLDKHSELFSNRHlPFTPRTLKTEAKSFLSQYRYYTPAKRK--KDLTDQRIQAETQAGLi--------sSFKPDFE 289 horse
XP_010587096 221 PTGDLLDKHSELFSNKElPFTPRTLKTDAKSFLSRYRYYTPARRK--K---AQRIEAETQTEVs---------SFNSDFE 286 African savanna...
XP_015205573 226 YSGDLLQKHSHCFTEDK-PFTPKTLKKETKSSLSQYRYYTPPRRKpaKHRTPLMVNQDTQTDNn---------SFSDNVG 295 spotted gar
XP_015205572 230 YSGDLLQKHSHCFTEDK-PFTPKTLKKETKSSLSQYRYYTPPRRKpaKHRTPLMVNQDTQTDNnsfsdnvgspQEKSi-- 306 spotted gar

EHH63817     289 TAETKNVTESE--------MNIK-Q--ASNCVTYDAKEKIAPLPLQG----HDLTWDEIKDdALQHSSPRAVCQYSLK-P 352 crab-eating mac...
XP_003472388 288 TSEIKKLTDSE--------VNTE-Q--ASNYMTYGTKEKLTPLSLQG----HDLTWDEIKDsAPRPSSQRTVCQYSAQ-R 351 domestic guinea...
Q80VP2       276 TAEKTSSKDSE--------VNIN-Q--VPNYTRNGAEDKIAPLPSQG----QNLAWDSIQDgILQQSSERASCKLSTE-F 339 house mouse
XP_007472732 290 RAELNNM-GSE--------VIID-EsdTSNYKIYGMKENFTPSQTLG----NSITWDKVKDdILHYPLSRASIPYYLQ-P 354 gray short-tail...
XP_012402844 278 NNIDSEEVIIN--------EPKT-SscNTYGMKEKIIPSQHLRNNLA----WEKVKENVLHyPFSRASIPYYLQPSPV-K 343 Tasmanian devil
4_pfamImport 281 NAATRDFACSS--------LFSKiFlvICKNVTYTKKKNFAFCA-------------EYKSsALKHC---VVCKCSAQ-R 335
2_pfamImport 273 GSERKVMTEQQ--------KMTV-K--AIYCVANDTESLTQKSASSS----EFFYWNRVSElLLLIFLIREASLYSEQ-L 336
XP_004010880 300 TVEIKNATDSE--------MNIR-Q--ASGCVSDGTKGRRAPLPLQG----HELLWDKMRDgALQCSSSRAVCQYSLQ-P 363 sheep
XP_006087046 288 TVETKDFTESE--------VTIK-Q--ASSCMTYGTKENITPSPSQE----KGLPWEEVKDgALQCSSARALCQYSVQpP 352 little brown bat
XP_023483992 290 TVETKNFKDSE--------L----Q--ASSCMTVGTQGKISPLPVEV----PGSPWDKVKDgARQCSss----------- 340 horse
XP_010587096 287 TAETENLTDSE--------VNIQ-Q--APSCLTHGTREK-TPLPSQK----YGLTWDEIKEgVLQRSAPRTISKYSLQ-- 348 African savanna...
XP_015205573 296 SPQEKSILPQDsftdhewsFEEH-L--IEDHLSYENLSKI---QNTG-----------MGNtDQLYSLSRI-PPERMK-S 356 spotted gar
XP_015205572 307 -lPQDSFTDHE--------WSFE-EhlIEDHLSYENLSKIQNTGMGNtdqlYSLS---------------RIPPERMK-S 360 spotted gar

EHH63817     353 PATSKiysdEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKH-LEEEKMRHLLHVLKVDLG 420 crab-eating macaque
XP_003472388 352 PWENKis-nEEELLYLSFIEDITNEILKLGLFSSRFLDRLFERHVKENKHrLKEEKMRHLLHGLKIDLG 419 domestic guinea pig
Q80VP2       340 SPDSKiysdEEELLYLSFMENVTDEILKLGLFSNRFLERLFERHIKKNKHhLEEGKMRYLLHGLKVDLG 408 house mouse
XP_007472732 355 SPVKKiqseEEELLYLSFIEDVTDEILKLGLFSNRVLERLFERHIEKNKHhLEEKKMRHMLHVLKVDLG 423 gray short-tailed opossum
XP_012402844 344 KIQSEeeelLYLSFIEDVTDEILKLGLFSNRVLERLFERHIEQNKHHLEEkKMRHMLHVLKVDLGCTPE 412 Tasmanian devil
4_pfamImport 336 QAIRKiqaeEEELMYLSFIQDITDEILRLGLFSNRALEMLFERHIEQNKRhLNETKMRHLLEILKIDLG 404
2_pfamImport 337 SARMNieavEDDHLYLTFIEDVTNDILDIGLFSNRVLEQLFECHIQENKNrLDESKMRHLLDVLKEDLG 405
XP_004010880 364 PSGRKmysdEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHhLEEEKMRRLLHVLKVDLG 432 sheep
XP_006087046 353 PSRRKiysdEEELLYLSFIEDVTDEILKLGLFSNRSLERLFERHIRQNKHhLEEGKMRHLLHILKVNLG 421 little brown bat
XP_023483992 341 --------sEEELLYLSFIEDITDEILKLGLFSNRFLERLFERHIKQNKHhLEEEKMRHLLRVLKVDLG 401 horse
XP_010587096 349 PSGRKihsdEEELLYLSFIEDITDEILKLGFFSNRFLERLFERHIKENKHhLEERKMRHLLHVLKVNLG 417 African savanna elephant
XP_015205573 357 PTMRKvtaeEEELRYLEFIADVTNEILTMGLYSNRVLERVFERHFEMNKHrLDNDKMRHLLDVLRHDLG 425 spotted gar
XP_015205572 361 PTMRKvtaeEEELRYLEFIADVTNEILTMGLYSNRVLERVFERHFEMNKHrLDNDKMRHLLDVLRHDLG 429 spotted gar
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